Ectopic fat accumulation and dysfunction in cultured myocytes-Regulatory role of Sirt1
| Project/Area Number |
24590877
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | The University of Tokyo |
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Principal Investigator |
ETO Masato 東京大学, 医学部附属病院, 准教授 (80282630)
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| Co-Investigator(Kenkyū-buntansha) |
IIJIMA Katsuya 東京大学, 高齢社会総合研究機構, 准教授 (00334384)
OTA Hidetaka 東京大学, 医学部附属病院, 助教 (20431869)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 骨格筋 / 脂肪酸 / ビタミンD / 異所性脂肪蓄積 / サルコペニア / 異所性脂肪 / Sirt1 |
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| Outline of Final Research Achievements |
Sarcopenia and ectopic fat deposition is related to aging and age-associated disorders. Therefore, to develop the efficient therapeutic strategy, the molecular mechanisms need to be clarified. Aim of this project was to examine the mechanisms underlying fatty acid-induced skeletal muscle dysfunction. Treatment with high dose of fatty acids induced lipid droplet formation and apoptosis accompanied with cellular insulin resistance, in C2C12 myocytes. Vitamin D3 induced Sirt-1 upregulation and restoration of fatty acid-induced insulin resistance. Finally, isoproterenol upregulated the expression levels of VDR in C2C12 cells.
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Report
(4 results)
Research Products
(5 results)
