The regression of atherosclerosis through the regulation of cellular senescence: the possible new therapy for Japanese lifestyle related diseases
Project/Area Number |
24590881
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
General internal medicine (including Psychosomatic medicine)
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Research Institution | Nagoya University |
Principal Investigator |
HAYASHI Toshio 名古屋大学, 医学部附属病院, 講師 (80303634)
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Co-Investigator(Kenkyū-buntansha) |
UMEGAKI Hiroyuki 名古屋大学, 大学院医学研究科, 講師 (40345898)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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Keywords | 抗老化 / 動脈硬化性疾患 / 遺伝子制御 / 一酸化窒素 / 内皮機能制御 |
Outline of Final Research Achievements |
We have found that cultured endothelial senescence induced by 3 days exposure to high glucose medium was found very close to human vascular lesion, and the high glucose is the stronger stimulus for endothelial senescence than other lifestyle related disease models such as hypertension or dyslipidemia. Further we performed 1) the study of the relation between postprandial hyperglycemic status and endothelial senescence, 2) the study of animal model of atherosclerosis and endothelial senescence and 3) the study of cellular senescence in human blood sample. The results might be helpful for understanding how endothelial senescence is important for human atheroslcerosis.
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Report
(4 results)
Research Products
(38 results)
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[Journal Article] Efficacy of HMG-CoA reductase inhibitors in the prevention of cerebrovascular attack in 1016 patients older than 75years among 4014 type 2 diabetic individuals2014
Author(s)
Hayashi T, Kubota K, Kawashima S, Sone H, Watanabe H, Ohrui T, Yokote K, Takemoto M, Araki A, Noda M, Noto H, Sakuma I, Yoshizumi M, Ina K, Nomura H, on behalf of Japan CDM group
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Journal Title
Int J Cardiol
Volume: 177
Issue: 3
Pages: 860-6
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Importance of high-density lipoprotein cholesterol levels in elderly diabetic individuals with type IIb dyslipidemia: A 2-year survey of cardiovascular events.2013
Author(s)
Ina K, Hayashi T, Araki A, Kawashima S, Sone H, Watanabe H, Ohrui T, Yokote K, Takemoto M, Kubota K, Noda M, Noto H, Ding QF, Zhang J, Yu ZY, Yoon BK, Nomura H, Kuzuya M; Japan CDM Group
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Journal Title
Geriatr Gerontol Int
Volume: 印刷中
Issue: 4
Pages: 806-10
DOI
Related Report
Peer Reviewed / Open Access
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