Regulation of metabolism related to the gastrointestinal tract via hypothalamus and autonomic nerves: in vivo and in vitro studies

• Project/Area Number: 24590889
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General internal medicine (including Psychosomatic medicine)
• Research Institution: Saga University
• Principal Investigator: FUJIMOTO Kazuma 佐賀大学, 医学部, 教授 (50181392)
• Co-Investigator(Kenkyū-buntansha): IWAKIRI Ryuichi 佐賀大学, 医学部, 准教授 (70232642) ; TODA Syuji 佐賀大学, 医学部, 教授 (80188755)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 中枢神経 / 小腸 / 肝臓 / 消化管粘膜 / アポトーシス / 増殖因子 / 脂肪摂取 / シグナル伝達 / 膵臓 / 増殖機構

Outline of Final Research Achievements

The present study aimed to examine the relationship between hypothalamic function and mucosal growth regulation of the gastrointestinal tract. The hypothalamus regulated mucosal growth and apoptosis of the rat intestinal mucosa, and the regulation was also important in the pancreas and liver. Dietary fat was crossly related to maintenance of the mucosa in the gastrointestinal tract, and the hypothalamus partly regulated the mechanism induced by dietary fat. The present study demonstrated that signal transduction related to apoptosis and cell growth was partly controlled by the hypothalamus in the in vitro study.

Research Products

• [Journal Article] Feeding with olive oil attenuates inflammation in dextran sulfate sodium-induced colitis in rat. (2014)
  • Author(s): Takashima T, Sakata Y, Iwakiri R, Shiraishi R, Oda Y, Inoue N, Nakayama A, Toda S, Fujimoto K.
  • Journal Title: J. Nutr. Biochem. Volume: 25 Pages: 186-192
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Ｆｅｅｄｉｎｇ ｗｉｔｈ ｏｌｉｖｅ ｏｉｌ ａｔｔｅｎｕａｔｅｓ ｉｎｆｌａｍｍａｔｉｏｎ ｉｎ ｄｅｘｔｒａｎ ｓｕｌｆａｔｅ ｓｏｄｉｕｍ－ｉｎｄｕｃｅｄ ｃｏｌｉｔｉｓ ｉｎ ｒａｔ (2014)
  • Author(s): Ｔａｋａｓｈｉｍａ Ｔ， Ｓａｋａｔａ Ｙ， Ｉｗａｋｉｒｉ Ｒ， Ｓｈｉｒａｉｓｈｉ Ｒ， Ｏｄａ Ｙ， Ｉｎｏｕｅ Ｎ， Ｎａｋａｙａｍａ Ａ， Ｔｏｄａ Ｓ， Ｆｕｊｉｍｏｔｏ Ｋ
  • Journal Title: Ｊ Ｎｕｔｒ Ｂｉｏｃｈｅｍ Volume: ２５ Pages: 186-192
  • Peer Reviewed
• [Journal Article] 小腸粘膜のアポトーシスはどのように制御されているのか (2013)
  • Author(s): 大谷顕史、藤本一眞
  • Journal Title: 分子消化器病 Volume: 10 Pages: 22-26
• [Journal Article] The role of PKC isoforms in the inhibition of NF-κB activation by vitamin K2 in human hepatocellular carcinoma cells. (2012)
  • Author(s): Xia J, Matsuhashi S, Hamajima H, Iwane S, Takahashi H, Eguchi Y, Mizuta T, Fujimoto K, Kuroda S, Ozaki I.
  • Journal Title: J. Nutr. Biochem. Volume: 23 Pages: 1668-1775
  • Peer Reviewed
• [Journal Article] Prevalence and associated metabolic factors of nonalcoholic fatty liver disease in the general population from 2009 to 2010 in Japan: a multicenter large retrospective study. (2012)
  • Author(s): Eguchi Y, Hyogo H, Ono M, Mizuta T, Ono N, Fujimoto K, Chayama K, Saibara T, JSG-NAFLD.
  • Journal Title: J. Gastroenterol. Volume: 47 Pages: 586-595
  • NAID: 10030650741
  • Peer Reviewed
• [Journal Article] Validation of the FIB4 index in a Japanese nonalcoholic fatty liver disease population (2012)
  • Author(s): Sumida Y, Yoneda M, Hyogo H, Itoh Y, Ono M, Fujii H, Eguchi Y, Suzuki Y, Aoki N, Kanemasa K, Fujita K, Chayama K, Saibara T, Kawada N, Fujimoto K, Kohgo Y, Yoshikawa T, Okanoue T
  • Journal Title: BMC Gastroenterol Volume: 12 Pages: 2-9
  • NAID: 120005122663
  • Peer Reviewed
• [Journal Article] 生活習慣と消化器疾患・治療薬 (2012)
  • Author(s): 藤瀬剛弘、藤本一眞
  • Journal Title: メディシーナル Volume: 2 Pages: 6-15
• [Presentation] 生活習慣病と脂質・胆汁酸代謝：脂肪組織はIGF-１を介して食道扁平上皮癌の増殖、浸潤、分化を促進し、アポトーシスを抑制する (2014)
  • Author(s): 中山敦史、岩切龍一、藤本一眞
  • Organizer: 第56回日本消化器病学会大会 シンポジウム
  • Place of Presentation: 神戸
  • Year and Date: 2014-10-23 – 2014-10-26