Relatihonship between aging, age-related diseases, and leukocyte telomere length in the oldest old
| Project/Area Number |
24590898
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | Keio University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HIROSE Nobuyoshi 慶應義塾大学, 医学部, 特別招聘教授 (90142421)
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| Research Collaborator |
ZGLINICKI Thomas Von Newcastle University, Institute of Ageing and Health
TAKAYAMA Michiyo 慶應義塾大学, 医学部, 特任講師 (60265824)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | テロメア長 / 百寿者 / 老年病 / 免疫老化 / 慢性炎症 / 健康長寿 / 細胞老化 / 末梢血テロメア長 / 国際研究者交流 / 老化 / 酸化ストレス / 国際情報交換 |
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| Outline of Final Research Achievements |
Leukocyte telomere length (LTL) is an emerging biomarker of aging, and associated with death from cardiovascular and infectious disease. Litte is known about LTL in centenarians. In this study, we measured LTL from 684 centenarians and 167 pairs of their offspring, 536 non-centenarian individual aged between 85-99 years old. we found that LTL actually decreased with age until late 90's, however, centenarians and especially semi-supercentenarians (individuals aged 105 years or older) exhibited longer LTL than expected for their ages. Moreover, centenarians' offspring maintained their LTL compared to non-centenarians. Decrease in percentage of CD28 lymphocyes is known to be associated with age-related decline in immune system (immmunesenescence). Interestingly, LTL in semi-supercentenarians were significantly correlated with CD28(+) lyphocytes. These resluts suggested that maintenance of LTL and immune competence could be hallmark of healthy longevity in humans.
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Report
(4 results)
Research Products
(30 results)
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[Journal Article] Denture Wearing during Sleep Doubles the Risk of Pneumonia in the Very Elderly.2015
Author(s)
inuma T, Arai Y, Abe Y, Takayama M, Fukumoto M, Fukui Y, Iwase T, Takebayashi T, Hirose N, Gionhaku N, Komiyama K.
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Journal Title
J Dent Res
Volume: 94(3 Suppl)
Issue: 3_suppl
Pages: 28S-36S
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Association of personality traits with oral health-related quality of life independently of objective oral health status: A study of community-dwelling elderly Japanese.2015
Author(s)
2.Takeshita H, Ikebe K, Kagawa R, Okada T, Gondo Y, Nakagawa T, Ishioka Y, Inomata C, Tada S, Matsuda K, Kurushima Y, Enoki K, Kamide K, Masui Y, Takahashi R, Arai Y, Maeda Y.
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Journal Title
J Dent.
Volume: 43(3)
Issue: 3
Pages: 342-9
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] The rs1333049 polymorphism on locus 9p21.3 and extreme longevity in Spanish and Japanese cohorts.2014
Author(s)
Pinós T, Fuku N, Cámara Y, Arai Y, Abe Y, Rodríguez-Romo G, Garatachea N, Santos-Lozano A, Miro-Casas E, Ruiz-Meana M, Otaegui I, Murakami H, Miyachi M, Garcia-Dorado D, Hinohara K, Andreu AL, Kimura A, Hirose N, Lucia A.
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Journal Title
Age (Dordr)
Volume: 36
Issue: 2
Pages: 933-943
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Significance of occlusal force for dietary fiber and vitamin intakes in independently living 70-year-old Japanese: from SONIC (Septuagenarians, Octogenarians, Nonagenarians Investigation with Centenarians) Study2014
Author(s)
C Inomata, K Ikebe, R Kagawa, H Okubo, S Sasaki, T Okada, H Takeshita, S Tada, K Matsuda, Y Kurushima, M Kitamura, S Murakami, Y Gondo, K Kamide, Y Masui, R Takahashi, Y Arai, Y Maeda
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Journal Title
J Dent
Volume: 42
Issue: 5
Pages: 556-564
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Variations of the angiotensin II type 1 receptor gene are associated with extreme human longevity.2012
Author(s)
Benigni A, Orisio S, Noris M, Iatropoulos P, Castaldi D, Kamide K, Rakugi H, Arai Y, Todeschini M, Ogliari G, Imai E, Gondo Y, Hirose N, Mari D, Remuzzi G.
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Journal Title
Age (Dordr).
Volume: not indicated
Related Report
Peer Reviewed
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