| Project/Area Number |
24590899
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | Showa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HISAMITSU Tadashi 昭和大学, 医学部・生理学講座・生体制御学部門, 教授 (20167604)
SUNAGAWA Masataka 昭和大学, 医学部・生理学講座・生体制御学部門, 准教授 (20514467)
NAKANISHI Takako 昭和大学, 医学部・生理学講座・生体制御学部門, 准教授 (00175499)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 末梢神経障害 / しびれ / 鍼 / アロディニア / 神経障害性疼痛 / 疼痛の非薬物治療 / 疼痛過敏 / 神経科学 / 化学療法誘発性末梢神経障害 / トランスレーショナルリサーチ / 鍼刺激 / 抗癌剤副作用 |
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| Outline of Final Research Achievements |
Paclitaxel (PTX) is a mitotic inhibitor used in cancer chemotherapy, but it develops chemotherapy-induced peripheral neuropathy (CIPN). Acupuncture is effective in the pathogenesis of pain. Therefore, we tested the influence of acupuncture stimulation (ACU) with PTX-CIPN model rats.
PTX-CIPN model rats produced significant mechano-hypersensitivity in the feet, but acupuncture rats did not show any decrease in the mechanical threshold caused by PTX. In the PTX and A-postPTX, P2Y12 receptor a large amount of microglia appeared. In conclusion, our study indicates that the satellite cells in the dorsal horn of spinal cord cause PTX-CIPN. However, applying ACU stimulation before PTX administration relieves it. Therefore, ACU stimulation is effective in preventing PTX-CIPN, but any delay in the start of ACU treatment may decrease its effect.
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