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Characterization of inflammageing in progeroid "Werner syndrome"

Research Project

Project/Area Number 24590902
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General internal medicine (including Psychosomatic medicine)
Research InstitutionTokyo Women's Medical University

Principal Investigator

Goto Makoto  東京女子医科大学, 医学部, その他 (00170465)

Project Period (FY) 2012-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords炎症老化 / 炎症 / 老化 / サイトカイン / CRP / ウエルナー症候群 / ケモカイン / 早老症 / ageing / chemokine / cytokine / infection / inflammation / Werner syndrome / inflammageing / 加齢 / werner syndrome / aging
Outline of Final Research Achievements

Minor-inflammation driven ”Inflammageing" was investigated by using 26-cytokine multiplex assay system in the sera from healthy volunteers aged between 0 and 100 and 41 patients with mutation-proven Werner syndrome.
TH2 cytokine levels including IL-4, 6, 13, 15 and GM-CSF were significantly elevated with healthy ageing. In the patients with Werner syndrome, TH2 cytokine levels including IL-4, 6, 10 and GM-CSF were significantly elevated compared with age sex-matched healthy counterpart, although age-associated elevation of TH2 cytokines was not observed.
Inflammageing may be a common deriving force to accelerate ageing both in healthy ageing and Werner syndrome.

Report

(5 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (20 results)

All 2016 2015 2014 2013 2012

All Journal Article (8 results) (of which Peer Reviewed: 8 results,  Open Access: 4 results,  Acknowledgement Compliant: 4 results) Presentation (9 results) (of which Int'l Joint Research: 1 results,  Invited: 5 results) Book (3 results)

  • [Journal Article] Ageing-associated inflammation(Inflammeging):Multiolex cytokine analysis in healthy Japanese individuals2016

    • Author(s)
      M. Goto, K. Hayata, J. Chiba, M. Matsuura, S. Iwaki-Egawa, Y. Watanabe
    • Journal Title

      Jacob Journal Gerontology

      Volume: 2 Pages: 1-7

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Multiplex cytokine analysis of Werner syndrome2015

    • Author(s)
      M. Goto, K. Hayata, J. Chiba, M. Matsuura, S. Iwaki-Egawa, Y. Watanabe
    • Journal Title

      Intractable & Rare Diseases Research

      Volume: 4 Issue: 4 Pages: 190-197

    • DOI

      10.5582/irdr.2015.01035

    • NAID

      130005109607

    • ISSN
      2186-361X, 2186-3644
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Reprogramming suppresses premature senescence phenotypes of Werner syndrome cells and maintains chromosomal stability over long-term culture2014

    • Author(s)
      Shimamoto A, Kagawa H, Zensho K, Sera Y, Kazuki Y, Osaki M, Oshimura M, Ishigaki Y, Hmasaki K, Kodama Y, Yuasa S, Fukuda K, Hirashima K, Seimiya H, Koyama H, Shimizu T, Takemoto M, Yokote K, Goto M, Tahara H.
    • Journal Title

      PLOS ONE

      Volume: 9 Issue: 11 Pages: 1-13

    • DOI

      10.1371/journal.pone.0112900

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] WRN protein as a novel erythroblast immunohistochemical marker with applications for the diagnosis of Werner syndrome2014

    • Author(s)
      Sadahira Y, Sugihara T, Fujiwara H, Nishimura H, Suetsugu Y, Takeshita M, Okamura S, Goto M.
    • Journal Title

      Virchows Arch

      Volume: 466 Issue: 3 Pages: 343-350

    • DOI

      10.1007/s00428-014-1703-6

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Werner syndrome:A changing pattern of clinical manifestations in Japan (1917~2008)2013

    • Author(s)
      Goto M,Ishikawa Y,Sugimoto M,Furuichi Y.
    • Journal Title

      BioScience Trends

      Volume: 7 Pages: 13-22

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Werner syndome:A changing pattern of clinical manifestations in Japan (1917~2008).2013

    • Author(s)
      Goto M, Ishikawa Y, Sugimoto M, Furuichi Y.
    • Journal Title

      BioScience Trends

      Volume: 7 Pages: 13-22

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] AGEing in Werner syndrome.2012

    • Author(s)
      Goto M, Iwaki-Egawa S, Watanabe Y.
    • Journal Title

      BioScience Trends

      Volume: 6 Pages: 1-5

    • NAID

      130004572561

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Aging-associated inflammation in healthy Japanese individuals and patients with Werner syndrome2012

    • Author(s)
      Goto M, Sugimoto K, Hayashi S et al.
    • Journal Title

      Exp Gerontol.

      Volume: 47 Issue: 12 Pages: 936-939

    • DOI

      10.1016/j.exger.2012.08.010

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Multiple cytokine analysis of inflammageing in normal Ageing and Werner syndrome2016

    • Author(s)
      M. Goto
    • Organizer
      Ageing 2016
    • Place of Presentation
      London, England
    • Year and Date
      2016-02-09
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Multiplex cytokine/chemokine analysis of ageing-associated inflammation in healthy Japanese individuals.2014

    • Author(s)
      Goto M, Hayata K, Chiba J, Matsuura M.
    • Organizer
      World Congress of Gerontology and Geriatrics 3rd International Conference on Healthy ageing in the changing world 2014
    • Place of Presentation
      インド バンガロール
    • Year and Date
      2014-11-18 – 2014-11-20
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Inflammageing associated cytokine/chemokine changes in healthy Japanese population.2014

    • Author(s)
      Goto M
    • Organizer
      BIT’s 2nd Annual World Congress of Geriatrics and Gerontology 2014
    • Place of Presentation
      中国 太原
    • Year and Date
      2014-10-24 – 2014-10-26
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Aging-associate inflammation in healthy Japanese individuals and Werner syndrome2013

    • Author(s)
      Goto M,Sugimoto Y,Furuichi Y,Matsuura M,Ishikawa Y,Iwaki-Egawa S,Watanabe Y.
    • Organizer
      The 20th IAGG World Congress of Gerontology
    • Place of Presentation
      Seoul,Korea
    • Related Report
      2013 Research-status Report
  • [Presentation] Acclerated in vivo and in vitro telomere loss in Werner syndrome2013

    • Author(s)
      Ishikawa N,Nakamura K,Shimomura N,Aida J,Goto M,Ishikawa Y,Matsuura M,Hatamochi K,Takubo K.
    • Organizer
      The 20th IAGG World Congress of Gerontology
    • Place of Presentation
      Seoul,Korea
    • Related Report
      2013 Research-status Report
  • [Presentation] Changing pattern of age-associated pathologies in Werner syndrome2013

    • Author(s)
      Got M.
    • Organizer
      The 20th IAGG World Congress of Gerontology
    • Place of Presentation
      Seoul,Korea
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Aging-associated inflammation in healthy individuals and Werner syndrome2013

    • Author(s)
      M Goto, M Sugimoto, Y Furuichi, M Matsuura, Y ishikawa, S Iwaki-Egawa, Y Watanabe
    • Organizer
      The 20th IAGG World Congress of Gerontology
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2012 Research-status Report
  • [Presentation] Accelerated in vivo and in vitro telomere loss in Werner syndrome2013

    • Author(s)
      N Ishikawa, K Nakamura, N Shimomura, J Aida, M Goto, Y Ishikawa M Matsuura, A Hatamochi K Takubo
    • Organizer
      The 20th IAGG World Congress of Gerontology
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2012 Research-status Report
  • [Presentation] Changing pattern of age-associated pathologies in Werner syndome2013

    • Author(s)
      M Goto
    • Organizer
      The 20th IAGG World Congress of Gerontology
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2012 Research-status Report
    • Invited
  • [Book] 老けない人になる36の習慣2015

    • Author(s)
      後藤 眞
    • Total Pages
      175
    • Publisher
      KADOKAWA
    • Related Report
      2015 Annual Research Report
  • [Book] 老化は治せる2013

    • Author(s)
      後藤 眞
    • Total Pages
      185
    • Publisher
      集英社
    • Related Report
      2013 Research-status Report
  • [Book] 老化は治せる2013

    • Author(s)
      後藤眞
    • Total Pages
      185
    • Publisher
      集英社
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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