| Project/Area Number |
24590902
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
Goto Makoto 東京女子医科大学, 医学部, その他 (00170465)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 炎症老化 / 炎症 / 老化 / サイトカイン / CRP / ウエルナー症候群 / ケモカイン / 早老症 / ageing / chemokine / cytokine / infection / inflammation / Werner syndrome / inflammageing / 加齢 / werner syndrome / aging |
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| Outline of Final Research Achievements |
Minor-inflammation driven ”Inflammageing" was investigated by using 26-cytokine multiplex assay system in the sera from healthy volunteers aged between 0 and 100 and 41 patients with mutation-proven Werner syndrome.
TH2 cytokine levels including IL-4, 6, 13, 15 and GM-CSF were significantly elevated with healthy ageing. In the patients with Werner syndrome, TH2 cytokine levels including IL-4, 6, 10 and GM-CSF were significantly elevated compared with age sex-matched healthy counterpart, although age-associated elevation of TH2 cytokines was not observed.
Inflammageing may be a common deriving force to accelerate ageing both in healthy ageing and Werner syndrome.
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