Characterization of inflammageing in progeroid "Werner syndrome"
Project/Area Number |
24590902
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
General internal medicine (including Psychosomatic medicine)
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Research Institution | Tokyo Women's Medical University |
Principal Investigator |
Goto Makoto 東京女子医科大学, 医学部, その他 (00170465)
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Project Period (FY) |
2012-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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Keywords | 炎症老化 / 炎症 / 老化 / サイトカイン / CRP / ウエルナー症候群 / ケモカイン / 早老症 / ageing / chemokine / cytokine / infection / inflammation / Werner syndrome / inflammageing / 加齢 / werner syndrome / aging |
Outline of Final Research Achievements |
Minor-inflammation driven ”Inflammageing" was investigated by using 26-cytokine multiplex assay system in the sera from healthy volunteers aged between 0 and 100 and 41 patients with mutation-proven Werner syndrome. TH2 cytokine levels including IL-4, 6, 13, 15 and GM-CSF were significantly elevated with healthy ageing. In the patients with Werner syndrome, TH2 cytokine levels including IL-4, 6, 10 and GM-CSF were significantly elevated compared with age sex-matched healthy counterpart, although age-associated elevation of TH2 cytokines was not observed. Inflammageing may be a common deriving force to accelerate ageing both in healthy ageing and Werner syndrome.
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Report
(5 results)
Research Products
(20 results)
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[Journal Article] Reprogramming suppresses premature senescence phenotypes of Werner syndrome cells and maintains chromosomal stability over long-term culture2014
Author(s)
Shimamoto A, Kagawa H, Zensho K, Sera Y, Kazuki Y, Osaki M, Oshimura M, Ishigaki Y, Hmasaki K, Kodama Y, Yuasa S, Fukuda K, Hirashima K, Seimiya H, Koyama H, Shimizu T, Takemoto M, Yokote K, Goto M, Tahara H.
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Journal Title
PLOS ONE
Volume: 9
Issue: 11
Pages: 1-13
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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