Role of Duodenal Iron Transporters in Cardio-Renal Anemia Syndrome
| Project/Area Number |
24590907
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAITO Yoshiro 兵庫医科大学, 医学部, 講師 (10446049)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 循環器 / 心不全 / 腎不全 / 貧血 / 鉄代謝調節機構 / 鉄 / エリスロポエチン / 心腎貧血連関 / 内科学 / 心腎連関 / 慢性腎臓病 |
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| Outline of Final Research Achievements |
We found the impaired expression of duodenal iron transporters in heart failure (HF) and chronic kidney disease (CKD) model rats. Duodenal expression of crucial iron transporters, such as duodenal cytochrome b and divalent metal transporter 1 was not increased in both HF and CKD model rats despite being under iron-deficient conditions. As a result, our data suggests that impaired intestinal iron absorption may be a novel therapeutic target in cardio-renal anemia syndrome.
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Report
(4 results)
Research Products
(11 results)
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[Journal Article] Cardiac remodeling in response to chronic iron deficiency: role of the erythropoietin receptor.2015
Author(s)
Naito Y, Sawada H, Oboshi M, Iwasaku T, Okuhara Y, Morisawa D, Eguchi A, Hirotani S, Mano T, Tsujino T, Masuyama T.
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Journal Title
Journal of Hypertension
Volume: 33
Issue: 6
Pages: 1267-1275
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Hepcidin is increased in the hypertrophied heart of Dahl salt-sensitive rats2014
Author(s)
Yoshiro Naito, Manami Hosokawa, Hisashi Sawada, Makiko Oboshi, Toshihiro Iwasaku, Yoshitaka Okuhara, Daisuke Morisawa, Akiyo Eguchi, Shinichi Hirotani, Mitsumasa Ohyanagi, Takeshi Tsujino, and Tohru Masuyama
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Journal Title
International Journal of Cardiology
Volume: 172
Issue: 1
Pages: e45-e47
DOI
Related Report
Peer Reviewed
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[Presentation] Hepcidin, a key regulator of iron metabolism in the hypertrophied heart2014
Author(s)
Manami Hosokawa, Yoshiro Naito, Hisashi Sawada, Makiko Oboshi, Aya Fujii, Toshihiro Iwasaku, Yoshitaka Okuhara, Daisuke Morisawa, Akiyo Eguchi, Shinichi Hirotani, Mitsumasa Ohyanagi, Takeshi Tsujino, and Tohru Masuyama
Organizer
第78回日本循環器学会学術集会
Place of Presentation
東京国際フォーラム、東京
Related Report
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[Presentation] Dietary Iron Restriction Prevents and Rescues Renal Injury in a Rat Model of Chronic Kidney Disease2012
Author(s)
Aya Fujii, Yoshiro Naito, Hisashi Sawada, Shinichi Hirotani, Toshihiro Iwasaku, Akiyo Eguchi, Yoshitaka Okuhara, Kojiro Miki, Mitsumasa Ohyanagi, Takeshi Tsujino, and Tohru Masuyama
Organizer
American Heart Association Scientific Sessions 2012
Place of Presentation
Los Angeles, USA
Related Report
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