Role of Duodenal Iron Transporters in Cardio-Renal Anemia Syndrome

• Project/Area Number: 24590907
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General internal medicine (including Psychosomatic medicine)
• Research Institution: Hyogo Medical University
• Principal Investigator: MASUYAMA Tohru 兵庫医科大学, 医学部, 教授 (70273670)
• Co-Investigator(Kenkyū-buntansha): NAITO Yoshiro 兵庫医科大学, 医学部, 講師 (10446049)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 循環器 / 心不全 / 腎不全 / 貧血 / 鉄代謝調節機構 / 鉄 / エリスロポエチン / 心腎貧血連関 / 内科学 / 心腎連関 / 慢性腎臓病

Outline of Final Research Achievements

We found the impaired expression of duodenal iron transporters in heart failure (HF) and chronic kidney disease (CKD) model rats. Duodenal expression of crucial iron transporters, such as duodenal cytochrome b and divalent metal transporter 1 was not increased in both HF and CKD model rats despite being under iron-deficient conditions. As a result, our data suggests that impaired intestinal iron absorption may be a novel therapeutic target in cardio-renal anemia syndrome.

Research Products

• [Journal Article] Cardiac remodeling in response to chronic iron deficiency: role of the erythropoietin receptor. (2015)
  • Author(s): Naito Y, Sawada H, Oboshi M, Iwasaku T, Okuhara Y, Morisawa D, Eguchi A, Hirotani S, Mano T, Tsujino T, Masuyama T.
  • Journal Title: Journal of Hypertension Volume: 33 Issue: 6 Pages: 1267-1275
  • DOI: 10.1097/hjh.0000000000000547
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Hepcidin is increased in the hypertrophied heart of Dahl salt-sensitive rats (2014)
  • Author(s): Yoshiro Naito, Manami Hosokawa, Hisashi Sawada, Makiko Oboshi, Toshihiro Iwasaku, Yoshitaka Okuhara, Daisuke Morisawa, Akiyo Eguchi, Shinichi Hirotani, Mitsumasa Ohyanagi, Takeshi Tsujino, and Tohru Masuyama
  • Journal Title: International Journal of Cardiology Volume: 172 Issue: 1 Pages: e45-e47
  • DOI: 10.1016/j.ijcard.2013.12.067
  • Peer Reviewed
• [Journal Article] Dietary iron restriction prevents further deterioration of renal damage in a chronic kidney disease rat model (2013)
  • Author(s): Yoshiro Naito, Aya Fujii, Hisashi Sawada, Shinichi Hirotani, Toshihiro Iwasaku, Yoshitaka Okuhara, Akiyo Eguchi, Mitsumasa Ohyanagi, Takeshi Tsujino, and Tohru Masuyama
  • Journal Title: Journal of Hypertension Volume: 31 Issue: 6 Pages: 1203-1213
  • DOI: 10.1097/hjh.0b013e328360381d
  • Peer Reviewed
• [Journal Article] Effect of iron restriction on renal damage and mineralocorticoid receptor signaling in a rat model of chronic kidney disease (2012)
  • Author(s): Yoshiro Naito, Aya Fujii, Hisashi Sawada, Shinichi Hirotani, Toshihiro Iwasaku, Akiyo Eguchi, Mitsumasa Ohyanagi, Takeshi Tsujino, and Tohru Masuyama
  • Journal Title: Journal of Hypertension Volume: 30 Issue: 11 Pages: 2192-2201
  • DOI: 10.1097/hjh.0b013e3283581a64
  • Peer Reviewed
• [Presentation] Possible Role of Duodenal Iron Transporters in the Development of Cardiorenal Anemia Syndrome (2015)
  • Author(s): 内藤由朗、澤田 悠、大星真貴子、増山 理
  • Organizer: 第79回日本循環器学会学術集会
  • Place of Presentation: ABCホール、大阪
  • Year and Date: 2015-04-24 – 2015-04-27
  • Invited
• [Presentation] 高血圧性肥大心における鉄代謝調節因子ヘプシジン発現 (2014)
  • Author(s): 細川愛実、 内藤由朗、澤田 悠、大星真貴子、岩破俊博、奥原祥貴、森澤大祐、江口明世、 廣谷信一、真野敏昭、 辻野 健、増山 理
  • Organizer: 第37回日本高血圧学会総会
  • Place of Presentation: パシフィコ横浜、横浜
  • Year and Date: 2014-10-16 – 2014-10-18
• [Presentation] Hepcidin, a key regulator of iron metabolism in the hypertrophied heart (2014)
  • Author(s): Manami Hosokawa, Yoshiro Naito, Hisashi Sawada, Makiko Oboshi, Aya Fujii, Toshihiro Iwasaku, Yoshitaka Okuhara, Daisuke Morisawa, Akiyo Eguchi, Shinichi Hirotani, Mitsumasa Ohyanagi, Takeshi Tsujino, and Tohru Masuyama
  • Organizer: 第78回日本循環器学会学術集会
  • Place of Presentation: 東京国際フォーラム、東京
• [Presentation] Dietary Iron Restriction Prevents and Rescues Renal Injury in a Rat Model of Chronic Kidney Disease (2012)
  • Author(s): Aya Fujii, Yoshiro Naito, Hisashi Sawada, Shinichi Hirotani, Toshihiro Iwasaku, Akiyo Eguchi, Yoshitaka Okuhara, Kojiro Miki, Mitsumasa Ohyanagi, Takeshi Tsujino, and Tohru Masuyama
  • Organizer: American Heart Association Scientific Sessions 2012
  • Place of Presentation: Los Angeles, USA
• [Presentation] 心不全患者における血清鉄濃度低下について
  • Author(s): 澤田 悠、内藤由朗、岩破俊博、奥原祥貴、森澤大祐、安藤友孝、江口明世、西村晃一、大星真貴子、廣谷信一、増山 理
  • Organizer: 第116回日本循環器学会近畿地方会
  • Place of Presentation: 大阪国際交流センター、大阪
• [Book] Heart View 心腎貧血症候群 (2014)
  • Author(s): 内藤 由朗、増山 理
  • Total Pages: 9
  • Publisher: メジカルビュー社
• [Book] 医学のあゆみ 心不全における鉄代謝調節機構 (2014)
  • Author(s): 内藤 由朗、増山 理
  • Total Pages: 2
  • Publisher: 医歯薬出版株式会社