A study to explore functional biomarkers for early Alzheimer's disease using MEG and amyloid-PET
| Project/Area Number |
24590908
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | National Center for Geriatrics and Gerontology |
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Principal Investigator |
NAKAMURA Akinori 国立研究開発法人国立長寿医療研究センター, 脳機能画像診断開発部, 室長 (00237380)
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| Co-Investigator(Kenkyū-buntansha) |
KATO Takashi 国立研究開発法人国立長寿医療研究センター, 脳機能画像開発研究部, 室長 (60242864)
ARAHATA Yutaka 国立研究開発法人国立長寿医療研究センター, 脳機能診療部, 医長 (80501212)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | アルツハイマー病 / 脳磁図 / アミロイドイメージング / 早期診断 / アルツハイマー型認知症 / アミロイド / PET / 体性感覚回復曲線 / 皮質興奮性 / 軽度認知障害 |
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| Outline of Final Research Achievements |
Magnetoencephalography (MEG) can detect brain network and synaptic functions very sensitively. The objective of this study, using MEG and amyloid-PET imaging, was to develop functional biomarkers for Alzheimer’s disease (AD) which are useful in the early stages of AD. We found two possible MEG biomarkers as follows: 1) Using somatosensory evoked magnetic field recovery function to paired electric stimuli, the cortical excitability associated with local amyloid deposition can be evaluated. 2) Functional network alterations in asymptomatic elders at risk for AD (amyloid-positive cognitively normal elders) could be detected by assessing functional connectivity of resting-state MEG signals.
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Report
(5 results)
Research Products
(75 results)
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[Journal Article] A multicenter study of the early detection of synaptic dysfunction in mild cognitive impairment using magnetoencephalography-derived functional connectivity.2015
Author(s)
Maestu F, Pena JM, Garces P, Gonzalez S, Bajo R, Bagic A, Cuesta P, Funke M, Makela J, Menasalvas E, Nakamura A, Parkkonen L, Lopez ME, del Pozo F, Sudre G, Zamrini E, Pekkonen E, Henson R, Becker J
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Journal Title
NeuroImage: Clinical
Volume: 9
Pages: 103-9
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Source Analysis of Spontaneous Magnetoencephalograpic Activity in Healthy Aging and Mild Cognitive Impairment: Influence of Apolipoprotein E Polymorphism.2014
Author(s)
Cuesta P, Barabash A, Aurtenetxe S, Garces P, Lopez ME, Bajo R, Llanero-Luque M, Ancin I, Cabranes JA, Marcos A, Sancho M, Nakamura A, Maestu F, Fernandez A
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Journal Title
J. Alzheimer Dis
Volume: 43
Issue: 1
Pages: 259-73
DOI
Related Report
Peer Reviewed
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[Journal Article] Influence of the APOE ε4 allele and MCI diagnosis in the disruption of the MEG resting state functional connectivity at sources space.2014
Author(s)
Cuesta P, Garces P, Castellanos N P, Lopez ME, Aurtenetxe S, Bajo R, Pineda J, Bruna R, Marin A G, Delgado M, Barabash A, Ancin I, Cabranes J A, Fernandez A, Sancho M, Marcos A, Nakamura A, Maestu F
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Journal Title
J. Alzheimer Dis
Volume: 44
Issue: 2
Pages: 493-505
DOI
Related Report
Peer Reviewed
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[Journal Article] Novel plasma biomarker surrogating cerebral amyloid deposition.2014
Author(s)
Kaneko N, Nakamura A, Washimi Y, Kato T, Sakurai T, Arahata Y, Bundo M, Takeda A, Niida S, Ito K, Toba K, Tanaka K, and Yanagisawa K
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Journal Title
Proc Jpn Acad Ser B
Volume: 90
Pages: 353-64
NAID
Related Report
Peer Reviewed
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[Presentation] PiB皮質集積数値指標の比較：DVR(Logan, SRTM2)とSUVR2015
Author(s)
藤原謙, 加藤隆司, 木村裕一, 岩田香織, 深谷直彦, 新畑豊, 乾好貴, 伊藤健吾, 中村昭範, MULNIAD study group
Organizer
第55回日本核医学会学術総会
Place of Presentation
東京
Year and Date
2015-11-05
Related Report
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[Presentation] One year changes in PiB SUVR values in Alzheimer’s disease, amnestic cognitive impairment, and cognitively normal subjects.2015
Author(s)
Kato T, Iwata K, Fujiwara K, Inui Y, Fukaya N, Ito K, Nakamura A, MULNIAD Study Group
Organizer
SNMMI 2015
Place of Presentation
Baltimore, Unisted States
Year and Date
2015-06-09
Related Report
Int'l Joint Research
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[Presentation] Longitudinal change of PiB accumulation with one year interval in Alzheimer’s disease, amnestic cognitive impairment, and cognitively normal subjects.2015
Author(s)
Kato T, Iwata K, Fujiwara K, Fukaya N, Inui Y, Ito K, Nakamura A, MULNIAD Study Group
Organizer
9th Human Amyloid Imaging
Place of Presentation
Miami, Florida, United States
Year and Date
2015-01-15
Related Report
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[Presentation] Correlation between cortical excitability and local amyloid βdeposition as evaluated by MEG and PiB-PET.2014
Author(s)
Nakamura A, Kato T, Yamagishi M, Iwata K, Kato K, Bundo M, Hattori H, Sakurai T, Arahata Y, Maess B, Ito K，MULNIAD study group
Organizer
Alzheimer’s Association International Conference 2014
Place of Presentation
Copenhagen，Denmark
Year and Date
2014-07-16
Related Report
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[Presentation] Magnetic resonance imaging of the Locus Coeruleus in young, non-demented older adults, MCI, and Alzheimer's disease.2014
Author(s)
Kato T, Iwata K, Kuratsubo I, Fukuda K, Takeda A, Washimi Y, Bundo M, Ito K, Nakamura A, MULNIAD Study group
Organizer
Alzheimer’s Association International Conference 2014
Place of Presentation
Copenhagen，Denmark
Year and Date
2014-07-12
Related Report
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