Analysis of the role of FGF10 in the stem cell niche of gastric carcinogenesis

Research Project

Project/Area Number	24590911
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Gastroenterology
Research Institution	Gifu University
Principal Investigator	TOMITA HIROYUKI 岐阜大学, 医学(系)研究科(研究院), 准教授 (50509510)
Project Period (FY)	2012-04-01 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000) Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000) Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords	増殖因子 / 癌 / 消化器
Outline of Final Research Achievements	We have found that expression of FGF10 is associated with gastric cancer in humans. FGF10 expression has an important role in gastric carcinoma, which makes a small tubular shape. Further, we have made FGF10 inducible transgenic ES cells and mice. Interestingly, we have found that FGF10-inducible mice develop hyperplasia in the stomach but not tumors. However, continuous induction of Fgf10, in particular, at low level, is associated with the development of the intraepithelial papillary neoplasms of bile duct.

Report

(4 results)