| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Outline of Final Research Achievements |
With persistent infection of Helicobacter pylori (H. pylori), gastric cancer develops by a multistep process occurring through the accumulation of genetic alterations in gastric epithelial cells. The mechanisms how the gastric epithelial cells with H. pylori infection and the resultant inflammatory response acquire the genetic changes leading to malignant transformation, however, remain unknown. Activation-induced cytidine deaminase (AID) induces somatic mutations in various host genes, and we demonstrated that H. pylori infection induced aberrant AID expression in gastric epithelial cells.
We plan to investigate the role of AID in the occurrence of genetic alterations, including genetic and epigenetic changes. We clarify the overall genetic alterations induced by aberrant AID activity using the next generation sequencing. A successful outcome of this research project would provide the novel insight into the molecular mechanisms of infection- and inflammation-associated carcinogenesis.
|
