Study of the molecular mechanism underlying genomic alterations during Helicobacter pylori-associated gastric carcinogenesis.
Project/Area Number |
24590915
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Gastroenterology
|
Research Institution | Kyoto University |
Principal Investigator |
MATSUMOTO Yuko 京都大学, 医学(系)研究科(研究院), 助教 (20452360)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | ヘリコバクター・ピロリ / 胃癌 / ゲノム異常 / ヘリコバクター・ピロリ菌 |
Outline of Final Research Achievements |
With persistent infection of Helicobacter pylori (H. pylori), gastric cancer develops by a multistep process occurring through the accumulation of genetic alterations in gastric epithelial cells. The mechanisms how the gastric epithelial cells with H. pylori infection and the resultant inflammatory response acquire the genetic changes leading to malignant transformation, however, remain unknown. Activation-induced cytidine deaminase (AID) induces somatic mutations in various host genes, and we demonstrated that H. pylori infection induced aberrant AID expression in gastric epithelial cells. We plan to investigate the role of AID in the occurrence of genetic alterations, including genetic and epigenetic changes. We clarify the overall genetic alterations induced by aberrant AID activity using the next generation sequencing. A successful outcome of this research project would provide the novel insight into the molecular mechanisms of infection- and inflammation-associated carcinogenesis.
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Report
(4 results)
Research Products
(5 results)
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[Journal Article] Leptin receptor somatic mutations are frequent in HCV-infected cirrhotic liver and associated with hepatocellular carcinoma.2014
Author(s)
Ikeda A, Shimizu T, Matsumoto Y, Fujii Y, Eso Y, Inuzuka T, Mizuguchi A, Shimizu K, Hatano E, Uemoto S, Chiba T, Marusawa H
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Journal Title
Gastroenterology
Volume: 146
Issue: 1
Pages: 222-232
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] A model of liver carcinogenesis originating from hepatic progenitor cells with accumulation of genetic alterations.2014
Author(s)
Soo Ki Kim, Akihiro Nasu, Junji Komori, Takahiro Shimizu, Yuko Matsumoto, Yasuko Minaki, Kenji Kohno, Kazuharu Shimizu, Shinji Uemoto, Tsutomu Chiba, Hiroyuki Marusawa.
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Journal Title
International Journal of Cancer
Volume: 134
Issue: 5
Pages: 1067-76
DOI
Related Report
Peer Reviewed / Open Access
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