| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
In this study, we revealed that acetaldehyde exposure in vitro causes acetaldehyde derived DNA adducts formation in the esophageal squamous epithelium, phosphorylation of p53 protein and cellular senescence. In human, the extent of DNA damage induced by acetaldehyde exposure was also correlated with the degree of change in the esophageal precancerous dysplasia. Inhibition of ALDH2 expression by siRNA increased DNA damage. Long-term exposure of acetaldehyde to the esophageal squamous epithelium in vitro affected esophageal squamous differentiation (keratinization), and caused confusion of polarity of nuclei of basal or parabasal cell, ballooning and parakeratotic changes, it was similar to the dysplastic squamous epithelium.
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