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A novel approach in the treatment of metastatic gastric cancer: targeting the STn synthase

Research Project

Project/Area Number 24590921
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Gastroenterology
Research InstitutionSapporo Medical University

Principal Investigator

SATO Yasushi  札幌医科大学, 医学部, 講師 (80343383)

Co-Investigator(Kenkyū-buntansha) TAKIMOTO Risyu  札幌医科大学, 医学部, 准教授 (10336399)
KATO Jyunji  札幌医科大学, 医学部, 教授 (20244345)
HIRAKAWA Masahiro  札幌医科大学, 医学部, 助教 (50561023)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords胃癌 / 転移 / STn抗原
Outline of Final Research Achievements

ST6GalNAc I is a sialyltransferase controlling the expression of sialyl-Tn antigen (STn), which is overexpressed in several epithelial cancers, including gastric cancer, and is highly correlated with cancer metastasis. However, the functional contribution of ST6GalNAc I to development or progression of gastric cancer remains unclear. We investigated the effects of suppression of ST6GalNAc I on gastric cancer in vitro and in vivo. ST6GalNAc I siRNA inhibited gastric cancer cell growth, migration, and invasion in vitro. Furthermore, intraperitoneal administration of ST6GalNAc I siRNA- liposome significantly inhibited peritoneal dissemination and prolonged the survival of xenograft model mice with peritoneal dissemination of gastric cancer. Therefore, ST6GalNAc I may be a potential target for treatment of metastasizing gastric cancer.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (2 results)

All 2014 2012

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results)

  • [Journal Article] RNAi-mediated gene silencing of ST6GalNAc I suppresses the metastatic potential in gastric cancer cells2014

    • Author(s)
      Tamura F, Sato Y, Hirakawa M, Yoshida M, Ono M, Osuga T, Okagawa Y, Uemura N, Arihara Y, Murase K, Kawano Y, Iyama S, Takada K, Hayashi T, Sato T, Miyanishi K, Kobune M, Takimoto R, Kato J.
    • Journal Title

      Gastric Cancer

      Volume: 23 Issue: 1 Pages: 85-97

    • DOI

      10.1007/s10120-014-0454-z

    • NAID

      40020700032

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Targeting anticancer drug delivery to pancreatic cancer cells using a fucose-bound nanoparticle approach.2012

    • Author(s)
      Yoshida M, Takimoto R, Murase K, Sato Y, Hirakawa M, Tamura F, Sato T, Iyama S, Osuga T, Miyanishi K, Takada K, Hayashi T, Kobune M, Kato J.
    • Journal Title

      PLoS One

      Volume: 7(7) Issue: 7 Pages: e39545-e39545

    • DOI

      10.1371/journal.pone.0039545

    • Related Report
      2012 Research-status Report
    • Peer Reviewed

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Published: 2013-05-31   Modified: 2019-07-29  

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