CD66a-mediated crosstalk between intestinal epithelia and lymphocytes
Project/Area Number |
24590936
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Gastroenterology
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Research Institution | Tokyo Medical and Dental University |
Principal Investigator |
NAGAISHI Takashi 東京医科歯科大学, 医学部附属病院, 助教 (60447464)
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Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Tetsuya 東京医科歯科大学, 大学院医歯学総合研究科, 寄附講座教授 (70265809)
WATANABE Mamoru 東京医科歯科大学, 大学院医歯学総合研究科, 教授 (10175127)
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Research Collaborator |
YAMAZAKI Motomi
ONIZAWA Michio
SUZUKI Masahiro
WATABE Taro
HOSOYA Akinori
JOSE Nisha
WANG Shuan
TOKAI Arisa
TSUGE Naoto
KAWAI Risa
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 炎症性腸疾患 / 粘膜免疫 / クロストーク / サイトカイン / CD66a |
Outline of Final Research Achievements |
Inflammatory Bowel Disease (IBD) is characterized by unrestrained lymphocyte activation that results in the production of a variety of pro-inflammatory cytokines and other mediators. Understanding the mechanisms of lymphocyte regulation is therefore of significant importance to dysregulated mucosal inflammation such as IBD. An area that is of significant interest is the cell autonomous mechanisms of T cell regulation through proteins that have natural inhibitory functions when expressed on T lymphocytes. In this regard, we have observed that CD66a has the general property of negatively regulating T cell responses initiated by antigen presentation. Defining the mechanisms of CD66a-mediated T cell regulation will lead to a significant understanding of the manner in which manipulation of this molecule may provide insights into novel therapeutic methods for the treatment of IBD.
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Report
(4 results)
Research Products
(54 results)
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[Journal Article] RIPK3 regulates p62-LC3 complex formation via the caspase-8-dependent cleavage of p62.2014
Author(s)
Y. Matsuzawa , S. Oshima, Y. Nibe, M.Kobayashi, C. Maeyashiki, Y. Nemoto, T. Nagaishi, R. Okamoto R, K. Tsuchiya, T. Nakamura, M. Watanabe.
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Journal Title
Biochem Biophys Res Commun
Volume: 456(1)
Issue: 1
Pages: 298-304
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Small intestinal stem cell identity is maintained with functional Paneth cells in heterotopically grafted epithelium onto the colon2014
Author(s)
Fukuda M, Mizutani T, Mochizuki W, Matsumoto T, Nozaki K, Sakamaki Y, Ichinose S, Okada Y, Tanaka T, Watanabe M, Nakamura T
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Journal Title
Genes & Development
Volume: 28(16)
Issue: 16
Pages: 1752-1757
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Myosin light chain kinase expression induced via tumor necrosis factor receptor 2 signaling in the epithelial cells regulates the development of colitis-associated carcinogenesis.2014
Author(s)
Suzuki M, Nagaishi T, Yamazaki M, Onizawa M, Watabe T, Sakamaki Y, Ichinose S, Totsuka M, Oshima S, Okamoto R, Shimonaka M, Yagita H, Nakamura T, Watanabe M.
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Journal Title
PLoS One
Volume: 9
Issue: 2
Pages: e88369-e88369
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] The short isoform of the CEACAM1 receptor in intestinal T cells regulates mucosal immunity and homeostasis via Tfh cell induction2012
Author(s)
Chen L, Chen Z, Baker K, Halvorsen EM, da Cunha AP, Flak MB, Gerber G, Huang YH, Hosomi S, Arthur JC, Dery KJ, Nagaishi T, Beauchemin N, Holmes KV, Ho JW, Shively JE, Jobin C, Onderdonk AB, Bry L, Weiner HL, Higgins DE, Blumberg RS
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Journal Title
Immunity
Volume: 37
Issue: 5
Pages: 930-946
DOI
Related Report
Peer Reviewed
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[Journal Article] Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5+stem cell2012
Author(s)
Yui S, Nakamura T, Sato T, Nemoto Y, Mizutani T, Zheng X, Ichinose S, Nagaishi T, Okamoto R, Tsuchiya K, Clevers H, and Watanabe M
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Journal Title
Nature Medicine
Volume: 18
Issue: 4
Pages: 618-623
DOI
Related Report
Peer Reviewed
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[Presentation] TNFR2 signaling in the epithelia may be involved in the development of colitis-associated tumor.2014
Author(s)
Watabe T, Nagaishi T, Suzuki M, Yamazaki M, Onizawa M, Jose N, Tokai A, Hosoya A, Totsuka M, Yagita H, Watanabe M
Organizer
第43回日本免疫学会総会学術集会
Place of Presentation
Kyoto International Conference Center (Kyoto)
Year and Date
2014-12-12
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