Novel therapeutic strategy for Crohn's disease by targeting an NK cell subset

• Project/Area Number: 24590937
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: NAGAHORI Masakazu 東京医科歯科大学, 医学部, 特任准教授 (60420254)
• Co-Investigator(Kenkyū-buntansha): NAGAISHI Takashi 東京医科歯科大学, 医学部附属病院, 助教 (60447464) ; WATANABE Mamoru 東京医科歯科大学, 大学院医歯学総合研究科, 教授 (10175127)
• Research Collaborator: YAMAZAKI Motomi ; ONIZAWA Michio ; SUZUKI Masahiro ; WATABE Taro ; HOSOYA Akinori ; JOSE Nisha ; WANG Shuan ; TOKAI Arisa ; TSUGE Naoto ; KAWAI Risa
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 炎症性腸疾患 / クローン病 / 新規治療法 / 粘膜免疫 / NK細胞

Outline of Final Research Achievements

We previously reported that IL-7-/-RAG-/- mice receiving naive T cells failed to induce colitis. Such abrogation of colitis may be associated not only with the lack of IL-7, but also with the induction of T cell apoptosis at an early stage of colitis development. Natural killer (NK) cells may be associated with the suppression of pathogenic T cells, and may induce apoptosis of CD4+ T cells. To further investigate these roles of NK cells, RAG-/- and IL-7-/-RAG-/- mice that had received naive T cells were depleted of NK cells. NK cell depletion at an early stage during effecter/memory T cell (TEM) development resulted in exacerbated colitis in recipient mice even in the absence of IL-7. Increased TEM were observed in the T cell-reconstituted RAG-/- recipients when NK cells were depleted. These results suggest that NK cells suppress colitis severity in the T cell-reconstituted recipient mice through targeting of colitogenic TEM present at the early stage of T cell development.

Research Products

• [Journal Article] RIPK3 regulates p62-LC3 complex formation via the caspase-8-dependent cleavage of p62. (2014)
  • Author(s): Y. Matsuzawa , S. Oshima, Y. Nibe, M.Kobayashi, C. Maeyashiki, Y. Nemoto, T. Nagaishi, R. Okamoto R, K. Tsuchiya, T. Nakamura, M. Watanabe.
  • Journal Title: Biochem Biophys Res Commun Volume: 456(1) Issue: 1 Pages: 298-304
  • DOI: 10.1016/j.bbrc.2014.11.075
  • Peer Reviewed / Open Access
• [Journal Article] Pre-illness isoflavone consumption and disease risk of ulcerative colitis: a multicenter case-control study in Japan. (2014)
  • Author(s): Ohfuji S, Fukushima W, Watanabe K, Sasaki S, Yamagami H, Nagahori M, Watanabe M, Hirota Y; Japanese Case-Control Study Group for Ulcerative Colitis
  • Journal Title: PLoS ONE Volume: 9 Issue: 10 Pages: e110270-e110270
  • DOI: 10.1371/journal.pone.0110270
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Comparison of Magnetic Resonance and Balloon Enteroscopic Examination of Deep Small Intestine in Patients with Crohn's Disease. (2014)
  • Author(s): Takenaka K, Ohtsuka K,Watanabe M et al
  • Journal Title: Gastroenterology Volume: [Epub ahead of print] Issue: 2 Pages: 334-342
  • DOI: 10.1053/j.gastro.2014.04.008
  • Peer Reviewed
• [Journal Article] Myosin light chain kinase expression induced via tumor necrosis factor receptor 2 signaling in the epithelial cells regulates the development of colitis-associated carcinogenesis. (2014)
  • Author(s): Suzuki M, Nagaishi T, Yamazaki M, Onizawa M, Watabe T, Sakamaki Y, Ichinose S, Totsuka M, Oshima S, Okamoto R, Shimonaka M, Yagita H, Nakamura T, Watanabe M.
  • Journal Title: PLoS One Volume: 9 Issue: 2 Pages: e88369-e88369
  • DOI: 10.1371/journal.pone.0088369
  • Peer Reviewed / Open Access
• [Journal Article] The clinical relevance of tacrolimus trough levels in outpatients with active ulcerative colitis (2014)
  • Author(s): Naganuma M, Suzuki Y, Matsuoka K, Kunisaki R, Yoshimura N, Nagahori M, Watanabe M
  • Journal Title: Nippon Shokakibyo Gakkai Zasshi Volume: 111 Issue: 2 Pages: 276-287
  • DOI: 10.11405/nisshoshi.111.276
  • NAID: 130003391998
  • ISSN: 0446-6586, 1349-7693
  • Peer Reviewed
• [Journal Article] Efficacy of salvage therapy and its effect on operative outcomes in patients with ulcerative colitis. (2014)
  • Author(s): Saito E, Nagahori M, Fujii T, Otsuka K, Watanabe M
  • Journal Title: Digestion Volume: 89 Issue: 1 Pages: 55-60
  • DOI: 10.1159/000356221
  • Peer Reviewed
• [Journal Article] Advancing magnetic resonance imaging in Crohn's disease. (2014)
  • Author(s): Fujii T, Naganuma M, Kitazume Y, Saito E, Nagahori M, Ohtsuka K, Watanabe M.
  • Journal Title: Digestion Volume: 89 Issue: 1 Pages: 24-30
  • DOI: 10.1159/000356210
  • NAID: 130005084744
  • Peer Reviewed
• [Journal Article] The 2nd edition of consensus statements for the diagnosis and management of intestinal Behcet's disease: indication of anti-TNFα monoclonal antibodies. (2014)
  • Author(s): Hisamatsu T, Ueno F, Matsumoto T, Kobayashi K, Koganei K, Kunisaki R, Hirai F,Nagahori M, Matsushita M, Kobayashi K, Kishimoto M, Takeno M, Tanaka M, Inoue N, Hibi T.
  • Journal Title: J Gastroenterol Volume: 49(1) Issue: 1 Pages: 156-62
  • DOI: 10.1007/s00535-013-0872-4
  • Peer Reviewed
• [Journal Article] Biologics treatment for ulcerative colitis (2013)
  • Author(s): Nagahori M, Fujii T, Saito E, Ohtsuka K, Watanabe M
  • Journal Title: Nippon Shokakibyo Gakkai Zasshi Volume: 110 Issue: 11 Pages: 1909-1915
  • DOI: 10.11405/nisshoshi.110.1909
  • NAID: 130003383310
  • ISSN: 0446-6586, 1349-7693
• [Journal Article] Incidence and characteristics of the 2009 influenza (H1N1) infections in inflammatory bowel disease patients. (2013)
  • Author(s): Naganuma M, Fujii T, Watanabe M. et al
  • Journal Title: J Crohns Colitis. Volume: 7 Issue: 4 Pages: 308-13
  • DOI: 10.1016/j.crohns.2012.06.019
  • Peer Reviewed
• [Journal Article] Poor recall of prior exposure to varicella zoster, rubella, measles, or mumps in patients with IBD (2013)
  • Author(s): Naganuma M, Nagahori M, Fujii T, Morio J, Saito E, Watanabe M
  • Journal Title: Inflamm Bowel Dis Volume: 19 Issue: 2 Pages: 418-422
  • DOI: 10.1002/ibd.23027
  • Peer Reviewed
• [Journal Article] Chronic Inflammatory Demyelinating Polyradiculoneuropathy in a Patient with Crohn's Disease (2013)
  • Author(s): Ohyagi , Akiyama J, Watanabe M et al
  • Journal Title: Internal Medicine Volume: 52 Issue: 1 Pages: 125-128
  • DOI: 10.2169/internalmedicine.52.8452
  • NAID: 130003365560
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed
• [Journal Article] The short isoform of the CEACAM1 receptor in intestinal T cells regulates mucosal immunity and homeostasis via Tfh cell induction (2012)
  • Author(s): Chen L, Chen Z, Baker K, Halvorsen EM, da Cunha AP, Flak MB, Gerber G, Huang YH, Hosomi S, Arthur JC, Dery KJ, Nagaishi T, Beauchemin N, Holmes KV, Ho JW, Shively JE, Jobin C, Onderdonk AB, Bry L, Weiner HL, Higgins DE, Blumberg RS
  • Journal Title: Immunity Volume: 37 Issue: 5 Pages: 930-946
  • DOI: 10.1016/j.immuni.2012.07.016
  • Peer Reviewed
• [Journal Article] Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5+stem cell (2012)
  • Author(s): Yui S, Nakamura T, Sato T, Nemoto Y, Mizutani T, Zheng X, Ichinose S, Nagaishi T, Okamoto R, Tsuchiya K, Clevers H, and Watanabe M
  • Journal Title: Nature Medicine Volume: 18 Issue: 4 Pages: 618-623
  • DOI: 10.1038/nm.2695
  • Peer Reviewed
• [Journal Article] Real-time analysis of P-glycoprotein-mediated drug transport across primary intestinal epithelium three-dimensionally cultured in vitro (2012)
  • Author(s): Mizutani T, Nakamura T, et al
  • Journal Title: Biochem Biophys Res Commun Volume: 419 Issue: 2 Pages: 238-243
  • DOI: 10.1016/j.bbrc.2012.01.155
  • Peer Reviewed
• [Journal Article] The development of colitogenic CD4+ T cells is regulated by IL-7 in collaboration with natural killer cell function in a murine model of colitis (2012)
  • Author(s): Yamaji O, Totsuka T
  • Journal Title: J Immunol Volume: 188 Issue: 6 Pages: 2524-2536
  • DOI: 10.4049/jimmunol.1100371
  • Peer Reviewed
• [Journal Article] NK細胞はIL-7と協調し腸炎惹起性T細胞の分化増殖を抑制する. (2012)
  • Author(s): 永石宇司, 渡辺守、 他.
  • Journal Title: 日本臨床免疫学会誌 Volume: 36 Pages: 333-333
  • Peer Reviewed
• [Journal Article] 慢性大腸炎モデルにおける腸炎惹起性T細胞の増殖はIL-7とNK細胞により制御される (2012)
  • Author(s): 永石宇司、渡辺 守、他
  • Journal Title: 消化器と免疫 Volume: in press
• [Presentation] The ulcerative colitis endoscopic Index of severity (UCEIS) is useful to evaluate endoscopic improvement and to predict medium-term prognosis in ulcerative colitis patients treated with tacrolimus. (2015)
  • Author(s): Matsuoka K, Saito E, Fujii T, Takenaka K, Nagahori M, Ohtsuka K, Watanabe M
  • Organizer: European Crohn’s and Colitis Organization 2015
  • Place of Presentation: Barcelona (Spain)
  • Year and Date: 2015-02-20
• [Presentation] 大腸上皮細胞特異的なTNFシグナルによるIBD合併大腸癌発生機構の解析 (2015)
  • Author(s): 永石宇司、渡部太郎、鈴木雅博、Jose Nisha、東海有沙、細谷明徳、鬼沢道夫、中村哲也、渡辺守
  • Organizer: 第11回日本消化管学会総会学術集会
  • Place of Presentation: 京王プラザホテル（東京）
  • Year and Date: 2015-02-13
• [Presentation] クローン病における内視鏡的粘膜治癒とMR enterocolonography (MREC)活動性の関係と長期予後についての検討 (2015)
  • Author(s): 藤井俊光、北詰良雄、竹中健人、斎藤詠子、長堀正和、大塚和朗、渡辺 守
  • Organizer: 第11回日本消化管学会総会学術集会
  • Place of Presentation: 京王プラザホテル（東京）
  • Year and Date: 2015-02-13
• [Presentation] 潰瘍性大腸炎におけるインフリキシマブ（IFX）濃度と短期の治療効果に関する検討 (2015)
  • Author(s): 斎藤詠子、長堀正和、竹中健人、藤井俊光、大塚和朗、渡辺 守
  • Organizer: 第11回日本消化管学会総会学術集会
  • Place of Presentation: 京王プラザホテル（東京）
  • Year and Date: 2015-02-13
• [Presentation] TNFR2 signaling in the epithelia may be involved in the development of colitis-associated tumor. (2014)
  • Author(s): Watabe T, Nagaishi T, Suzuki M, Yamazaki M, Onizawa M, Jose N, Tokai A, Hosoya A, Totsuka M, Yagita H, Watanabe M
  • Organizer: 第43回日本免疫学会総会学術集会
  • Place of Presentation: Kyoto International Conference Center (Kyoto)
  • Year and Date: 2014-12-12
• [Presentation] タクロリムスを使用した難治性潰瘍性大腸炎の内視鏡的検討 (2014)
  • Author(s): 齊藤詠子、大塚和朗、竹中健人、藤井俊光、永石宇司、長堀正和、渡辺守
  • Organizer: 第99回日本消化器内視鏡学会関東地方会
  • Place of Presentation: シェーンバッハ砂防（東京）
  • Year and Date: 2014-12-07
• [Presentation] 難治性潰瘍性大腸炎（UC）における内科治療と手術例での予後の検討 (2014)
  • Author(s): 齊藤詠子、長堀正和、渡辺守
  • Organizer: Japanese Digestive Disease Week 2014
  • Place of Presentation: 神戸国際会議場 (兵庫)
  • Year and Date: 2014-10-25
• [Presentation] クローン病におけるMR enterocolonography (MREC)での病態評価と入院・手術予測 (2014)
  • Author(s): 藤井俊光、長堀正和、渡辺守
  • Organizer: Japanese Digestive Disease Week 2014
  • Place of Presentation: 神戸国際会議場 (兵庫)
  • Year and Date: 2014-10-23
• [Presentation] The expression of myosin light chain kinase induced by NF-kB activation is involved in the development of colitis-associated cancer. (2014)
  • Author(s): Jose N, Nagaishi T, Watabe T, Tokai A, Suzuki M, Yamazaki M, Watanabe M
  • Organizer: United European Gastroenterology Week 2014
  • Place of Presentation: Vienna (Austria)
  • Year and Date: 2014-10-22
• [Presentation] MR enterocolonography can identify patients who need additional treatment by predicting recurrence, hospitalization and surgery of Crohn’s disease patients in remission. (2014)
  • Author(s): Fujii T, Naganum M, Kitazume Y, Takenaka K, Saito E, Nagahori M, Otsuka K, Watanabe M
  • Organizer: United European Gastroenterology Week 2014
  • Place of Presentation: Vienna (Austria)
  • Year and Date: 2014-10-20
• [Presentation] Magnetic resonance enterocolonography can detect small intestinal active lesions in Crohn’s disease; comparison with balloon enteroscopy. (2014)
  • Author(s): Takenaka K, Ohtsuka K, Kitadume Y, Fujii T, Saito E, Nagahori M, Watanabe M
  • Organizer: United European Gastroenterology Week 2014
  • Place of Presentation: Vienna (Austria)
  • Year and Date: 2014-10-20
• [Presentation] Epithelial MLCK induced via NF-kB activation may be involved in the development of colitis-associated carcinogenesis. (2014)
  • Author(s): Watabe T, Nagaishi T, Suzuki M, Yamazaki M, Jose N, Tokai A, Watanabe M
  • Organizer: 第73回日本癌学会学術総会
  • Place of Presentation: Pacifico Yokohama (神奈川)
  • Year and Date: 2014-09-27
• [Presentation] 腸管上皮細胞における特異的TNFシグナルはIBD合併大腸癌の発生を促進させる (2014)
  • Author(s): 渡部太郎、永石宇司、鈴木雅博、山崎元美、鬼沢道夫、Jose Nisha、東海有沙、渡辺守
  • Organizer: 第51回日本消化器免疫学会総会
  • Place of Presentation: 京都大学芝蘭会館（京都）
  • Year and Date: 2014-07-11
• [Presentation] Myosin light chain kinase induced by NF-kB is involved in the development of colitis-associated carcinogenesis. (2014)
  • Author(s): Nagaishi T, Suzuki M, Yamazaki M, Onizawa M, Watabe T, Watanabe M
  • Organizer: Federation of Clinical Immunology Societies 2014
  • Place of Presentation: Chicago (U.S.A.)
  • Year and Date: 2014-06-26
• [Presentation] Outcome of induction and maintenance therapy for refractory ulcerative colitis. (2014)
  • Author(s): Saito E, Nagahori M, Watanabe M
  • Organizer: Asian Organization for Crohn’s and Colitis 2014
  • Place of Presentation: Seoul (Korea)
  • Year and Date: 2014-06-21
• [Presentation] Comparison of magnetic resonance and balloon enteroscopic examination of deep small intestine inpatients with Crohn’s disease. (2014)
  • Author(s): Takenaka K, Otsuka K, Nagahori M, Fujii T, Saito E, Watanabe M
  • Organizer: Asian Organization for Crohn’s and Colitis 2014
  • Place of Presentation: Seoul (Korea)
  • Year and Date: 2014-06-20
• [Presentation] IBD合併大腸癌モデルの発生過程における上皮細胞特異的TNFシグナルの解析 (2014)
  • Author(s): 鈴木雅博、永石宇司、鬼澤道夫、渡辺守
  • Organizer: 第100回日本消化器病学会総会
  • Place of Presentation: 東京国際フォーラム（東京）
  • Year and Date: 2014-04-25
• [Presentation] IBDの治療；Real practiceにおける選択とその根拠 (2014)
  • Author(s): 齊藤詠子、長堀正和、渡辺守
  • Organizer: 第100回日本消化器病学会総会
  • Place of Presentation: 東京国際フォーラム（東京）
  • Year and Date: 2014-04-25
• [Presentation] Myosin Light Chain Kinase is Involved in the Development of an Animal Model of Colitis-Associted Tumor. (2013)
  • Author(s): Suzuki M, Nagaishi T, Onizawa M, Yamazaki M, Tsuge N, Watanabe M
  • Organizer: 11th International Congress of Mucosal Immunology
  • Place of Presentation: Vancouver（Canada）
• [Presentation] Natural killer cells abrogate an animal model of colitis by targeting the early stage of pathogenic T cell development. (2013)
  • Author(s): Nagaishi T, Yamaji O, Onizawa M, Suzuki M, Kanai T, Watanabe M
  • Organizer: AGA 2013
  • Place of Presentation: Orlando（USA）
• [Presentation] Natural killer cells regulate the early stage of pathogenic T cell development in an IBD models. (2013)
  • Author(s): Nagaishi T, Yamaji O, Suzuki M, Yamazaki M, Watanabe M
  • Organizer: United European Gastoroenterology week( UEGW)
  • Place of Presentation: Berlin（Germany）
• [Presentation] Myosin light chain kinase induced by NF-kB is involved in the development of colitis-associated cancer. (2013)
  • Author(s): Suzuki M, Nagaishi T, Onizawa M, Yamazaki M, Yagita H, Watanabe M.
  • Organizer: 日本免疫学会 2013
  • Place of Presentation: 千葉（幕張メッセ）
• [Presentation] 難治性潰瘍性大腸炎の手術・非手術症例の背景因子と術後予後の検討 (2013)
  • Author(s): 齊藤詠子、長堀正和、藤井俊光、大塚和朗、渡辺 守
  • Organizer: 消化管学会
  • Place of Presentation: 東京（新宿）
• [Presentation] 潰瘍性大腸炎(UC)入院例における手術症例の背景因子と術後予後の検討 (2013)
  • Author(s): 齊藤詠子、長堀正和、渡辺 守
  • Organizer: 消化器病学会総会
  • Place of Presentation: 鹿児島（かごしま県民交流センター）
• [Presentation] 潰瘍性大腸炎(UC)に対するインフリキシマブ(IFX)の中長期予後の内視鏡的検討 (2013)
  • Author(s): 齊藤詠子、長堀正和、渡辺 守
  • Organizer: 第85回 日本消化器内視鏡学会総会
  • Place of Presentation: 京都（国立京都国際 会館）
• [Presentation] IBDに対する内科治療とその限界 (2013)
  • Author(s): 齊藤詠子、長堀正和、渡辺 守
  • Organizer: JDDW2013
  • Place of Presentation: 東京（品川）
• [Presentation] カプセル&バルーン内視鏡の各施設の工夫 クローン病におけるMREC(MR enterocolonography)とバルーン内視鏡併用の有用性 (2013)
  • Author(s): 齊藤 詠子、大塚 和朗、新田 沙由梨、藤井 俊光、岡田 英理子、長堀 正和、荒木 昭博、渡辺 守
  • Organizer: 第96回日本消化器内視鏡学関東地方会
  • Place of Presentation: 東京
• [Presentation] 炎症性腸疾患の病態理解と実験モデル (2013)
  • Author(s): 永石 宇司、渡辺 守
  • Organizer: 日本臨床免疫学会 2013
  • Place of Presentation: 下関（海峡メッセ下関）
  • Invited
• [Presentation] Analysis of indication and volume of colonoscopy for ulcerative colitis patients in the era of mucosal healing.
  • Author(s): Nagahori M,Saito E, Fujii T, Otsuka K, Watanabe M
  • Organizer: １st Annual Meeting of AOCC
  • Place of Presentation: 東京
• [Presentation] MR enterocolonography can predict clinical recurrence of Crohn's disease.
  • Author(s): Fuji T, Naganuma M, Kitazume Y, Saito E, Nagahori M,
  • Organizer: DDW 2013
  • Place of Presentation: Orlando（USA）
• [Presentation] MR enterocolonography is useful to predict clinical recurrence of Crohn's disese and identify patients who need more aggressive treatment.
  • Author(s): Fujii T, Naganuma M, Kitazume Y, Saito E, Nagahori M, Ohtsuka K, Watanabe M
  • Organizer: United European Gastoroenterology week( UEGW)
  • Place of Presentation: Berlin（Germany）
• [Presentation] 潰瘍性大腸炎(UC)に対するインフリキシマブ(IFX)の中長期予後の内視鏡的検討
  • Author(s): 齋藤詠子、長堀正和、渡辺 守
  • Organizer: 第85回 日本消化器内視鏡学会総会
  • Place of Presentation: 京都（国立京都国際 会館）
• [Presentation] クローン病におけるMREC(MR enterocolonography)とバルーン内視鏡併用の有用性
  • Author(s): 齊藤詠子、大塚和朗、新田沙由梨、藤井俊光、岡田英里子、長堀正和、荒木昭博、渡辺 守
  • Organizer: 内視鏡学会関東地方会
  • Place of Presentation: 東京
• [Presentation] 「炎症性（IBD）の基礎知識」
  • Author(s): 長堀 正和
  • Organizer: 第12回 市民公開講座｢炎症性腸疾患の治療をめぐって」
  • Place of Presentation: 東京（東京医科歯科大学）
• [Presentation] クローン病における小腸病変に対するバルーン内視鏡所見とMR所見の比較
  • Author(s): 竹中健人、大塚和朗、藤井俊光、長堀正和、斉藤詠子、荒木昭博、新田沙由梨 鈴木雅博、渡辺守
  • Organizer: 第97回日本消化器内視鏡学会関東地方会
  • Place of Presentation: 東京
• [Presentation] クローン病腸管狭窄に対して内視鏡的バルーン拡張術を行った一例
  • Author(s): 新田沙由梨、大塚和朗、藤井俊光、齊藤詠子、岡田英理子、東正新、大岡真也、長堀正和、荒木昭博、朝比奈靖浩、渡辺守
  • Organizer: お茶の水消化器病セミナー
  • Place of Presentation: 東京
• [Presentation] クローン病感受性遺伝子A20による腸炎惹起機構
  • Author(s): 大島 茂、松沢 優、高原政宏、小林正典、仁部洋一、前屋舗千明、永石宇司、土屋輝一郎、岡本隆一、中村哲也、渡辺 守
  • Organizer: 厚生労働科学研究 難治性疾患克服研究事業 「難治性炎症性腸管障害に関する調査研究」
  • Place of Presentation: 東京（味の素（株）本社ビル）
• [Presentation] Natural killer cells regulate the early stage of pathogenic T cell development in a murine model of colitis.
  • Author(s): Nagaishi T, Watanabe M et al.
  • Organizer: Immuno 2013
  • Place of Presentation: Barcelona
• [Presentation] Natural killer cells regulate the early stage of pathogenic T cell development in a murine model of colitis.
  • Author(s): Nagaishi T.（招待講演）
  • Organizer: IDIBAPS-Center Esther Koplowitz
  • Place of Presentation: Barcelona
  • Invited
• [Presentation] Use of proton pomp inhibitor and upper gastrointestinal symptoms in IBD patients
  • Author(s): Nagahori M, Watanabe M et al.
  • Organizer: Congress of ECCO 2013
  • Place of Presentation: Vienna
• [Presentation] Natural killer cells suppress an animal model of colitis by targeting the early stage of pathogenic T cell development.
  • Author(s): Nagaishi T, Watanabe M et al.
  • Organizer: 日本免疫学会総会 2012
  • Place of Presentation: Kobe
• [Presentation] Natural killer cells suppress an animal model of IBD by targeting the early stage of pathogenic T cell development.
  • Author(s): Nagaishi T, Watanabe M et al.
  • Organizer: Asian IBD Symposium 2012
  • Place of Presentation: Seoul
• [Presentation] Natural killer cells regulate colitis by targeting the early stage of pathogenic T cell development.
  • Author(s): Nagaishi T, Watanabe M et al.
  • Organizer: Federation of Clinical Immunology Societies 2012
  • Place of Presentation: Vancouver
• [Presentation] Intravenous tacrolimus therapy can rapidly induce remission in refractory ulcerative colitis
  • Author(s): Fujii T, Naganuma M, Saito E, Nagahori M, Watanabe M
  • Organizer: DDW2012
  • Place of Presentation: San Diego
• [Presentation] MR enterocolonography (MREC)の実際とクローン病小腸大腸病変の評価における有用性
  • Author(s): 長堀正和、渡辺 守 他
  • Organizer: JDDW 2012
  • Place of Presentation: 神戸
• [Presentation] Natural killer cells suppress an animal model of IBD by targeting the early stage of pathogenic T cell development.
  • Author(s): 永石宇司, 渡辺守、 他.
  • Organizer: 日本臨床免疫学会総会 2012
  • Place of Presentation: 東京
• [Presentation] クローン病診療における当院でのMREC(MR enterocolonography)の試み モニタリングとしての有用性
  • Author(s): 長堀正和、藤井俊光、齊藤詠子、渡辺 守、大塚和朗
  • Organizer: 第30回日本大腸検査学会総会
  • Place of Presentation: 東京
• [Presentation] 慢性大腸炎モデルにおける腸炎惹起性T細胞の増殖はIL-7とNK細胞により制御される
  • Author(s): 永石宇司, 渡辺守、 他.
  • Organizer: 日本消化器免疫学会総会 2012
  • Place of Presentation: 鹿児島
• [Presentation] 炎症性腸疾患患者における抗TNFα受容体拮抗薬の選択に関する研究
  • Author(s): 藤井俊光、長堀正和、長沼誠、渡辺 守、他
  • Organizer: 第98回 日本消化器病学会総会
  • Place of Presentation: 東京
• [Presentation] 炎症性腸疾患患者における抗TNFa受容体拮抗薬の選択に関する研究
  • Author(s): 長堀正和、長沼誠、渡辺 守、他
  • Organizer: 第98回 日本消化器病学会総会
  • Place of Presentation: 東京
• [Book] IBD Research (2014)
  • Author(s): 竹中健人、大塚和朗、北詰良雄、藤井俊光、齋藤詠子、長堀正和、松岡克善、藤岡友之、渡辺守
  • Total Pages: 8
  • Publisher: 先端医学社
• [Book] Intestine (2014)
  • Author(s): 大塚和朗、渡辺大輔、小形典之、長堀正和、藤井俊光、齊藤詠子、和田祥城、荒木昭博、渡辺 守
  • Total Pages: 5
  • Publisher: 日本メディカルセンター
• [Book] 実践！IBD診療 １．IBD診療のコツ (2014)
  • Author(s): 長堀正和
  • Total Pages: 2
  • Publisher: 医学出版
• [Book] 実践！IBD診療 ２．各治療の最適化とコツ (2014)
  • Author(s): 長堀正和
  • Total Pages: 6
  • Publisher: 医学出版
• [Book] GI Research (2012)
  • Author(s): 鈴木雅博、永石宇司、渡辺 守
  • Publisher: 先端医学社
• [Book] GI Research (2012)
  • Author(s): 長堀正和、渡辺 守
  • Total Pages: 4
  • Publisher: 先端医学社