Treatment of intestinal fibrosis of Crohn disease by regulation of expression of glycan chains
Project/Area Number |
24590938
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Gastroenterology
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Research Institution | Niigata University |
Principal Investigator |
SUZUKI Kenji 新潟大学, 医歯学総合病院, 講師 (00303123)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
Keywords | siRNA / 線維化 / 糖鎖 / クローン病 / 消化管狭窄 |
Outline of Final Research Achievements |
We have revealed that the carbohydrate sulphotransferase CHST15 gene plays an important role in intestinal fibrosis in Crohn's disease, and developed a siRNA drug, STNM01, which selectively inhibits the expression of the gene, collaborating with the Stelic Institute of Regenerative Medicine, Tokyo. In this study, we have revealed that this new siRNA drug inhibited the progression of fibroblasts into myofibroblasts, and decresed the collagen production by fibroblasts, and that STNM01 could ameliorate chronic fibrosing DSS colitis. Additionally, we have revealed the overexpression of CHST15 in the colon of patients with Crohn's diseasae, suggesting that CHS15 could be a promissing target of the siRNA drug for the treatment of intestinal fibrosis in Crohn's disease.
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Report
(4 results)
Research Products
(17 results)
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[Journal Article] Telmisartan treatment targets inflammatory cytokines to suppress the pathogenesis of acute colitis induced by dextran sulphate sodium.2015
Author(s)
Arumugam S, Sreedhar R, Thandavarayan RA, Giridharan VV, Karuppagounder V, Pitchaimani V, Afrin MR, Miyashita S, Nomoto M, Harima M, Suzuki H, Nakamura T, Nakamura M, Suzuki K, Watanabe K.
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Journal Title
Cytokine
Volume: 15
Issue: 2
Pages: 305-312
DOI
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Peer Reviewed
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[Journal Article] ITGA3 and ITGB4 expression biomarkers estimate the risks of locoregional and hematogenous dissemination of oral squamous cell carcinoma.2013
Author(s)
Nagata M, Noman AA, Suzuki K, Kurita H, Ohnishi M, Ohyama T, Kitamura N, Kobayashi T, Uematsu K, Takahashi K, Kodama N, Kawase T, Hoshina H, Ikeda N, Shingaki S, Takagi R
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Journal Title
BMC Cancer
Volume: 13
Issue: 1
Pages: 410-410
DOI
Related Report
Peer Reviewed
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[Presentation] Endoscopic submucosal injection of a synthesized anti-CHST15 dsRNA for sulfated glycosaminoglycan is a safe and beneficial treatment for patients with Crohn's disease who do not respond sufficiently to the conventional treatment.2014
Author(s)
Suzuki K, Yokoyama J, Kawachi Y, Honda Y, Asakura H, Okazaki K, Suzuki Y, Sameshima Y, Fukushima T, Fujii M, Hashiguchi T, Mizumoto S, Sugahara K, Yoenayma H.
Organizer
2014 Digestive disease week, Chicago, USA.
Place of Presentation
Chicago, IL, USA
Year and Date
2014-05-04
Related Report
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[Book] Vimentin: Concepts and molecular mechanisms2013
Author(s)
Suzuki K, Nagata M, Kawase T, Uematsu K, Honda Y, Kawauchi Y, Yokoyama J, Arumugam S, Thandavarayan RA, Yoneyama H, Watanabe K, Asakura H.
Total Pages
174
Publisher
Nova Science Publishers, Inc.
Related Report
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[Book] Mast cells. Phenotypic features, biological functions and role in immunity.2013
Author(s)
Suzuki K, Nagata M, Kawase T, Uematsu K, Honda Y, Kawauchi Y, Yokoyama J, Arumugam S, Thandavarayan RA, Yoneyama H, Watanabe H, Asakura H.
Total Pages
301
Publisher
Nova Science Publishers, Inc.
Related Report