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Development of a new immunoassay for the accurate

Research Project

Project/Area Number 24590940
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Gastroenterology
Research InstitutionShiga University of Medical Science

Principal Investigator

ANDOH Akira  滋賀医科大学, 医学部, 教授 (90252395)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords炎症性腸疾患 / 内科 / 薬物動態 / インフリキシマブ / アダリムマブ
Outline of Final Research Achievements

Our results suggest that ATI levels of ≤35 μg/mL should be the standard indication for dosage increase. For cases where no improvement is evident following dosage increase, switching to other biopharmaceuticals should be considered. Serum infliximab trough levels are correlated with ESR as well as CRP, serum albumin, and fecal calprotectin levels in Crohn’s disease patients on infliximab maintenance therapy. The results suggest that serum infliximab trough levels should be ≥1.0 μg/mL for effective therapy, and the dosage of infliximab should be increased when serum infliximab trough levels fall below 1.0 μg/mL. Increasing the dosage is not effective and efficacious serum infliximab trough levels cannot be obtained in patients with high ATI levels. Thus, the presence or absence of ATIs is important in determining treatment strategy.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (14 results)

All 2014 2013 2012

All Journal Article (7 results) (of which Peer Reviewed: 7 results,  Acknowledgement Compliant: 1 results) Presentation (6 results) (of which Invited: 2 results) Book (1 results)

  • [Journal Article] Characterization of gut microbiota profiles by disease activity in patients with Crohn's disease using data mining analysis of terminal restriction fragment length polymorphisms.2014

    • Author(s)
      Andoh A, Kobayashi T, Kuzuoka H, et al.
    • Journal Title

      Biomed rep

      Volume: 2 Pages: 370-373

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Involvement of interleukin-17A-induced expression of heat shock protein 47 in intestinal fibrosis in Crohn's disease2014

    • Author(s)
      Honzawa Y, Nakase H, Shiokawa M, Yoshino T, Imaeda H, Matsuura M, Kodama Y, Ikeuchi H, Andoh A, Sakai Y, Nagata K, Chiba T
    • Journal Title

      Gut

      Volume: 63 Issue: 12 Pages: 1902-12

    • DOI

      10.1136/gutjnl-2013-305632

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mannan-binding protein, a C-type serum lectin, recognizes primary colorectal carcinomas through tumor-associated Lewis glycans.2014

    • Author(s)
      M. Nonaka, H. Imaeda, S. Matsumoto, BY Ma, N. Kawasaki, E. Mekata, A. Andoh, Y. Saito, T. Tani, Y. Fujiyama, T. Kawasaki.
    • Journal Title

      J Immunol

      Volume: 192 Issue: 3 Pages: 1294-1301

    • DOI

      10.4049/jimmunol.1203023

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between serum infliximab trough levels and endoscopic activities in patients with Crohn's disease under scheduled maintenance treatment.2014

    • Author(s)
      Imaeda H, Bamba S, Takahashi K, Fujimoto T, Ban H, Tsujikawa T, Sasaki M, Fujiyama Y, Andoh A.
    • Journal Title

      Journal of Gastroenterology

      Volume: 49 Issue: 4 Pages: 674-682

    • DOI

      10.1007/s00535-013-0829-7

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Clinical utility of newly developed immunoassays for serum concentrations of adalimumab and anti-adalimumab antibodies in patients with Crohn's disease.2014

    • Author(s)
      Imaeda H, Takahashi K, Fujimoto T, Bamba S, Tsujikawa T, Sasaki M, Fujiyama Y, Andoh A.
    • Journal Title

      Journal of Gastroenterology

      Volume: 49 Issue: 1 Pages: 100-109

    • DOI

      10.1007/s00535-013-0803-4

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Epithelial expression of interleukin-37b in inflammatory bowel disease.2013

    • Author(s)
      Imaeda H, Takahashi K, Fujimoto T, Kasumi E, Ban H, Bamba S, Sonoda H, Shimizu T, Fujiyama Y, Andoh A.
    • Journal Title

      Clin Exp Immunol.

      Volume: 172 Issue: 3 Pages: 410-416

    • DOI

      10.1111/cei.12061

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Decreased abundance of Faecalibacterium prausnitzii in the gut microbiota of Crohn's disease2013

    • Author(s)
      Fujimoto T, Imaeda H, Takahashi K, Kasumi E, Bamba S, Fujiyama Y, Andoh A.
    • Journal Title

      Journal of Gastroenterology and Hepatology

      Volume: 28 Issue: 4 Pages: 613-619

    • DOI

      10.1111/jgh.12073

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] How does gut microbiota infuluence the mucosal immunity?2014

    • Author(s)
      Akira Andoh
    • Organizer
      The 2nd annual meeting of AOCC
    • Place of Presentation
      Seoul, 大韓民国
    • Year and Date
      2014-06-20
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 小腸病変を有するクローン病の内視鏡所見と予後の検討2014

    • Author(s)
      馬場重樹、辻川知之、安藤 朗
    • Organizer
      日本消化器内視鏡学会
    • Place of Presentation
      福岡サンパレス
    • Year and Date
      2014-05-15
    • Related Report
      2014 Annual Research Report
  • [Presentation] 生物学的製剤二次無効と対策2014

    • Author(s)
      安藤 朗
    • Organizer
      日本消化器病学会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2014-04-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] 炎症性腸疾患におけるmucin-1の機能解析2014

    • Author(s)
      西田淳史、安藤 朗、ほか
    • Organizer
      日本消化器病学会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2014-04-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] 血中インフリキシマブ濃度測定法の検討2014

    • Author(s)
      高橋憲一郎、安藤 朗 ほか
    • Organizer
      日本消化器病学会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2014-04-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] 肥満の成立における腸内細菌叢の役割2012

    • Author(s)
      安藤 朗
    • Organizer
      第10回日本機能性食品医用学会総会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
    • Invited
  • [Book] 胃と腸 炎症性腸疾患20132013

    • Author(s)
      安藤 朗
    • Total Pages
      7
    • Publisher
      医学書院
    • Related Report
      2013 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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