Development of a new immunoassay for the accurate
Project/Area Number |
24590940
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Gastroenterology
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Research Institution | Shiga University of Medical Science |
Principal Investigator |
ANDOH Akira 滋賀医科大学, 医学部, 教授 (90252395)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 炎症性腸疾患 / 内科 / 薬物動態 / インフリキシマブ / アダリムマブ |
Outline of Final Research Achievements |
Our results suggest that ATI levels of ≤35 μg/mL should be the standard indication for dosage increase. For cases where no improvement is evident following dosage increase, switching to other biopharmaceuticals should be considered. Serum infliximab trough levels are correlated with ESR as well as CRP, serum albumin, and fecal calprotectin levels in Crohn’s disease patients on infliximab maintenance therapy. The results suggest that serum infliximab trough levels should be ≥1.0 μg/mL for effective therapy, and the dosage of infliximab should be increased when serum infliximab trough levels fall below 1.0 μg/mL. Increasing the dosage is not effective and efficacious serum infliximab trough levels cannot be obtained in patients with high ATI levels. Thus, the presence or absence of ATIs is important in determining treatment strategy.
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Report
(4 results)
Research Products
(14 results)
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[Journal Article] Involvement of interleukin-17A-induced expression of heat shock protein 47 in intestinal fibrosis in Crohn's disease2014
Author(s)
Honzawa Y, Nakase H, Shiokawa M, Yoshino T, Imaeda H, Matsuura M, Kodama Y, Ikeuchi H, Andoh A, Sakai Y, Nagata K, Chiba T
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Journal Title
Gut
Volume: 63
Issue: 12
Pages: 1902-12
DOI
Related Report
Peer Reviewed
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[Journal Article] Mannan-binding protein, a C-type serum lectin, recognizes primary colorectal carcinomas through tumor-associated Lewis glycans.2014
Author(s)
M. Nonaka, H. Imaeda, S. Matsumoto, BY Ma, N. Kawasaki, E. Mekata, A. Andoh, Y. Saito, T. Tani, Y. Fujiyama, T. Kawasaki.
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Journal Title
J Immunol
Volume: 192
Issue: 3
Pages: 1294-1301
DOI
Related Report
Peer Reviewed
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