• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Analysis of plasma exosome containing micro RNA in gastrointestinal cancer

Research Project

Project/Area Number 24590944
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Gastroenterology
Research InstitutionKyushu University

Principal Investigator

BABA Eishi  九州大学, 医学(系)研究科(研究院), 教授 (00315475)

Co-Investigator(Kenkyū-buntansha) NIIRO Hiroaki  九州大学, 大学病院, 准教授 (20380636)
AKASHI Koichi  九州大学, 大学院医学研究院, 教授 (80380385)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords消化器がん / がん幹細胞 / エクソゾーム / 微小環境 / 可溶性因子 / 消化器癌 / 癌幹細胞
Outline of Final Research Achievements

Human gastrointestinal tumor has cancer stem cell (CSC) population, which possess self-renewing potential. The present study revealed the stemness in the EpCAM-high and CD44-positive human colorectal cancer cells. Only these cells efficiently form sphere in vitro. Soluble factors including exosomes may play an important role in the interaction between colorectal CSCs and the cells forming microenvironment. The present study suggested that these interactions might possibly induce of stemness in non-CSCs.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (9 results)

All 2015 2014 2012 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (6 results) Book (1 results) Remarks (1 results)

  • [Journal Article] CIN85 is required for Cbl-mediated regulation of antigen receptor signaling in human B cells2012

    • Author(s)
      Niiro H,…, Tsukamoto H, et al(16名中12番目)
    • Journal Title

      Blood

      Volume: 119 Issue: 10 Pages: 2263-2273

    • DOI

      10.1182/blood-2011-04-351965

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Placiticity of CD44+ colorectal cancer stem cells depend on TGF-beta-induced epithelial mesenchymal transition:evidences from an ex vivo culture2015

    • Author(s)
      Michitaka Nakano, Hiroshi Ariyama, Shingo Tamura, Taichi Isobe, Kohta Miyawaki, Hitoshi Kusaba, Takashi Ueki, Eishi Baba, Koichi Akashi
    • Organizer
      American Association for Cancer Research (AACR) 2015
    • Place of Presentation
      Philadelphia
    • Year and Date
      2015-04-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] Placiticity of CD44+ colorectal cancer stem cells depend on TGF-beta-induced epithelial mesenchymal transition:evidences from an ex vivo culture2014

    • Author(s)
      中野倫孝,有山寛、田村真吾、磯部大地、宮脇恒太、奥村祐太、草場仁志、植木隆、馬場英司、赤司浩一
    • Organizer
      第73回日本癌学会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Placiticity of CD44+ colorectal cancer stem cells depend on TGF-beta-induced epithelial mesenchymal transition:evidences from an ex vivo culture2014

    • Author(s)
      中野倫孝,有山寛、田村真吾、磯部大地、宮脇恒太、奥村祐太、草場仁志、植木隆、馬場英司、赤司浩一
    • Organizer
      第12回日本臨床腫瘍学会
    • Place of Presentation
      福岡
    • Year and Date
      2014-07-17 – 2014-07-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] Placiticity of CD44+ colorectal cancer stem cells depend on TGF-beta-induced epithelial mesenchymal transition:evidences from an ex vivo culture2014

    • Author(s)
      Michitaka Nakano, Hiroshi Ariyama, Shingo Tamura, Taichi Isobe, Kohta Miyawaki, Hitoshi Kusaba, Takashi Ueki, Eishi Baba, Koichi Akashi
    • Organizer
      American Association for Cancer Research (AACR) 2014
    • Place of Presentation
      Dan Diego
    • Year and Date
      2014-04-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] Plasticity of CD44+ colorectal cancer stem cells depends on TGF-beta-induced epithelial mesenchymal transition (EMT): evidences from ex vivo culture system2014

    • Author(s)
      Michitaka Nakano, Hiroshi Ariyama, Eishi Baba et al.
    • Organizer
      American Association for Cancer Research
    • Place of Presentation
      San Diego, USA
    • Related Report
      2013 Research-status Report
  • [Presentation] Both E-Cadherin-positive and negative cells of colorectal cancer stem cell population possess tumor initiating potential.2012

    • Author(s)
      Tamura S, Isobe T, Baba E, Nakano M, Komoda M, Takaishi S, Kusaba H, Ueki T, Akashi K.
    • Organizer
      The 71st Annual Meeting of the Japanese Cancer Association
    • Place of Presentation
      Sapporo
    • Related Report
      2012 Research-status Report
  • [Book] 日本臨床増刊2014

    • Author(s)
      中野倫孝、馬場英司、赤司浩一
    • Total Pages
      4
    • Publisher
      日本臨床社
    • Related Report
      2013 Research-status Report
  • [Remarks] 九州大学医学部病態修復内科学

    • URL

      http://www.1nai.med.kyushu-u.ac.jp

    • Related Report
      2013 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi