Comprehensive analysis for mechanism(s) of visceral hypersensitivity associated with morphological changes in glial cells response to stress during a growth process
| Project/Area Number |
24590950
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Osaka City University |
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Principal Investigator |
TOMINAGA Kazunari 大阪市立大学, 医学(系)研究科(研究院), 准教授 (80336768)
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| Co-Investigator(Kenkyū-buntansha) |
ARAKAWA Tetsuo 大阪市立大学, 大学院医学研究科, 教授 (60145779)
FUJIWARA Yasuhiro 大阪市立大学, 大学院医学研究科, 准教授 (40285292)
WATANABE Toshio 大阪市立大学, 大学院医学研究科, 准教授 (50336773)
TANIGAWA Tetsuya 大阪市立大学, 大学院医学研究科, 講師 (70423879)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 腸管グリア細胞 / 腸管収縮反応 / 知覚過敏 / 過敏性腸症候群 / ストレス / グリア細胞 / 大腸収縮運動 / 刺激過敏性 / 腸管運動 / 腸管神経系 / ストレス環境 / 腸管過敏性 |
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| Outline of Final Research Achievements |
Male Wistar rats underwent 3-h maternal separation (a chronic stress) during postnatal days 2-14 and 4-h water-immersion stress (an acute stress) in adulthood (at 8 weeks). Glial fibrillary acidic protein (GFAP) expression and the number of enteric neurons were unchanged by these stresses. The density of GFAP-positive EGC processes overlapped with the neurons and the extent of bulbous swelling of terminals increased according to the stress intensity: control, acute stress, maternal separation, and combination. Electrical field stimulation (EFS)-induced colonic contractions were significantly greater in the combined stress rats than in controls. Colonic EGCs exhibited structural alterations according to the stress intensity and associated with stress-induced colonic hyper-contraction, which may underlie the pathogenesis of irritable bowel syndrome.
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Report
(4 results)
Research Products
(7 results)
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[Presentation] Structural plasticity of colonic glial cells enhanced by acute stress in adulthood was associated with colonic hyper-contraction in maternally separated rats2013
Author(s)
Yoshiko Fujikawa, Kazunari Tominaga, Fumio Tanaka, Mitsue Sogawa, Hirokazu Yamagami, Tetsuya Tanigawa, Masatsugu Shiba, Kenji Watanabe, Toshio Watanabe, Yasuhiro Fujiwara, Tetsuo Arakawa
Organizer
Digestive Diseases Weeks
Place of Presentation
オーランド、Orange County Convention Center in Orlando
Related Report
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