Mucosal IgG plasma cell as a novel therapeutic target in the pathogenesis of ulcerative colitis .
Project/Area Number |
24590951
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Gastroenterology
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Research Institution | Keio University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
TOKUTAKE Mina 慶應義塾大学, 医学部, 研究員 (30468524)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
Keywords | 潰瘍性大腸炎 / IgG産生形質細胞 / ケモカイン受容体 / 免疫複合体 / IgG形質細胞 |
Outline of Final Research Achievements |
Chronic inflammation characterized by IgG-producing plasma cell infiltration of colonic mucosa is a histological hallmark of ulcerative colitis (UC).IgG plasma cells that were markedly increased in number in the inflamed mucosa of UC patients showed a distinct expression profile (CCR10 low /CXCR4 high) compared with IgA plasma cells (CCR10 high/CXCR4 low).IgG-immunocomplex(IC) stimulation activated intestinal CD14+ macrophages that were increased in number in the inflamed mucosa of UC patients via FcgR, and induced the extensive production of pro-inflammatory cytokines. IgG-IC may promote inflammatory response in CD14+ macrophages independent from signaling pathway in bacteria stimulation. IgG-IC signaling via FcgR and IgG plasma cell could be novel therapeutic targets for UC.
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Report
(4 results)
Research Products
(14 results)
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[Journal Article] TGR5 signaling inhibits the production of pro-inflammatory cytokines by in vitro differentiated inflammatory and intestinal macrophages in Crohn’s disease.2013
Author(s)
Yoneno K, Hisamatsu T, Shimamura K, Kamada N, Ichikawa R, Kitazume MT, Mori M, Uo M, Namikawa Y, Matsuoka K, Sato T, KoganeiK, Sugita A, Kanai T and Hibi T
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Journal Title
Immunology
Volume: 139(1)
Pages: 19-29
Related Report
Peer Reviewed
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[Journal Article] Activated Hepatic Stellate Cells Mediate the Differentiation of Macrophages.2013
Author(s)
Chang J, Hisamatsu T, Shimamura K, Yoneno K, Adachi M, Naruse H, Igarashi T, Higuchi H, Matsuoka K, Kitazume MT, Ando S, Kamada N, Kanai T, and Hibi T.
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Journal Title
Hepatology Research
Volume: [Epub ahead of print]
NAID
Related Report
Peer Reviewed
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[Journal Article] Inducible colitis-associated glycome capable of stimulating the proliferation of memory CD4+ T cells2012
Author(s)
Nishida A, Nagahama K, Imaeda H, Ogawa A, Lau CW, Kobayashi T, Hisamatsu T, Preffer FI, Mizoguchi E, Ikeuchi H, Hibi T, Fukuda M, Andoh A, Blumberg RS, Mizoguchi A
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Journal Title
J Exp Med.
Volume: 209(13)
Pages: 2383-94
Related Report
Peer Reviewed
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[Journal Article] T-helper 17 and interleukin-17-producing lymphoid tissue inducer-like cells make different contributions to colitis in mice.2012
Author(s)
Ono Y, Kanai T, Sujino T, Nemoto Y, Kanai Y, Mikami Y, Hayashi A, Matsumoto A, Takaishi H, Ogata H, Matsuoka K, Hisamatsu T, Watanabe M, Hibi T.
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Journal Title
Gastroenterology.
Volume: 143(5)
Pages: 1288-97
Related Report
Peer Reviewed
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[Journal Article] Bile acids induce monocyte differentiation toward interleukin-12 hypo-producing dendritic cells via a TGR5-dependent pathway.2012
Author(s)
Ichikawa R, Takayama T, Yoneno K, Kamada N, Kitazume MT, Higuchi H, Matsuoka K, Watanabe M, Itoh H, Kanai T, Hisamatsu T, Hibi T.
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Journal Title
Immunology.
Volume: 136(2)
Pages: 153-62
Related Report
Peer Reviewed
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[Journal Article] Novel, objective, multivariate biomarkers composed of plasma amino acid profiles for the diagnosis and assessment of inflammatory bowel disease.2012
Author(s)
Hisamatsu T, Okamoto S, Hashimoto M, Muramatsu T, Andou A, Uo M, Kitazume MT, Matsuoka K, Yajima T, Inoue N, Kanai T, Ogata H, Iwao Y, Yamakado M, Sakai R, Ono N, Ando T, Suzuki M, Hibi T.
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Journal Title
Related Report
Peer Reviewed
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