Involvement of androgen receptor and unfolded protein response in human liver and pancreatic cancers
Project/Area Number |
24590955
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Gastroenterology
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Research Institution | Chiba University |
Principal Investigator |
KANDA TATSUO 千葉大学, 医学(系)研究科(研究院), 講師 (20345002)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | アンドロジェンレセプター / 小胞体ストレス / 自然免疫 / 肝細胞癌 / 膵癌 / C型肝炎ウイルス / GRP78 / アポトーシス / 肝癌 / Sorafenib / AR |
Outline of Final Research Achievements |
(1) Endoplasmic reticulum (ER) stress response plays a key role in hepatic cell damage induced by an innate immune response. (2) Androgen receptor (AR) and ER-stress response are cooperatively involved in human liver cancer, one of the male-dominant cancers. (3) Hepatitis C virus (HCV) infection enhances GRP78 expression, which confers to the resistance against apoptosis in HCV-infected hepatocytes. (4) ER stress response plays an important role in pancreatic cancer cell line KP-2, in which AR highly expresses.
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Report
(4 results)
Research Products
(11 results)
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[Journal Article] The JAK2 inhibitor AZD1480 inhibits hepatitis A virus replication in Huh7 cells.2015
Author(s)
Jiang X, Kanda T, Nakamoto S, Saito K, Nakamura M, Wu S, Haga Y, Sasaki R, Sakamoto N, Shirasawa H, Okamoto H, Yokosuka O
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Journal Title
Biochem Biophys Res Commun
Volume: 印刷中
Issue: 4
Pages: 908-912
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Suppression of La Antigen Exerts Potential Antiviral Effects against Hepatitis A Virus.2014
Author(s)
Jiang X, Kanda T, Wu S, Nakamoto S, Saito K, Shirasawa H, Kiyohara T, Ishii K, Wakita T, Okamoto H, Yokosuka O.
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Journal Title
PLoS One.
Volume: 9
Issue: 7
Pages: e101993-e101993
DOI
Related Report
Peer Reviewed / Open Access
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