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Elucidation of the enhanced IFN action by the non-coding RNA and its application on HCV treatment

Research Project

Project/Area Number 24590956
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Gastroenterology
Research InstitutionThe University of Tokyo

Principal Investigator

YOSHIDA Haruhiko  東京大学, 医学部附属病院, 登録研究員 (60240305)

Co-Investigator(Kenkyū-buntansha) OTSUKA Motoyuki  東京大学, 医学部附属病院消化器内科, 助教 (90518945)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
KeywordsIFN / 非コードRNA / HCV / インターフェロン / microRNA / SOCS3 / エピジェネティクス
Outline of Final Research Achievements

miR122 was identified as an enhancer of IFN action. miR122 enhanced methylation of the SOCS3 DNA promoter and decreased its expression, which enhances IFN signaling. Apigenin decreases miR122 expression. Therefore, cotreatment of IFN and apigenin may be useful for the inhibition of HCV replication through the augmentation of IFN signaling.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (12 results)

All 2015 2014 2013 2012 Other

All Journal Article (11 results) (of which Peer Reviewed: 11 results,  Open Access: 2 results) Remarks (1 results)

  • [Journal Article] Diagnostic and therapeutic application of noncoding RNAs for hepatocellular carcinoma.2015

    • Author(s)
      Shibata C, Otsuka M, Kishikawa T, Ohno M, Yoshikawa T, Takata A, Koike K.
    • Journal Title

      World J Hepatol.

      Volume: 7 Pages: 1-6

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Decreased miR122 in hepatocellular carcinoma leads to chemoresistance with increased arginine2015

    • Author(s)
      Kishikawa T, Otsuka M, Tan PS, Ohno M, Sun X, Yoshikawa T, Shibata C, Takata A, Kojima K, Takehana K, Ohishi M, Ota S, Noyama T, Kondo Y, Sato M, Soga T, Hoshida Y, Koike K.
    • Journal Title

      Oncotarget.

      Volume: in press

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The flavonoid apigenin inhibits hepatitis C virus replication by decreasing mature microRNA122 levels.2014

    • Author(s)
      Shibata C, Ohno M, Otsuka M, Kishikawa T, Goto K, Muroyama R, Kato N, Yoshikawa T, Takata A, Koike K.
    • Journal Title

      Virology

      Volume: 462-463 Pages: 42-48

    • DOI

      10.1016/j.virol.2014.05.024

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of the expression of the liver cancer susceptibility gene MICA by microRNAs.2013

    • Author(s)
      Kishikawa T, Otsuka M, Yoshikawa T, Ohno M, Takata A, Shibata C, Kondo Y, Akanuma M, Yoshida H, Koike K.
    • Journal Title

      Sci Rep.

      Volume: 3 Issue: 1 Pages: 2739-2739

    • DOI

      10.1038/srep02739

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Unique haploinsufficient role of the microRNA-processing molecule Dicer1 in a murine colitis-associated tumorigenesis model.2013

    • Author(s)
      Yoshikawa T, Otsuka M, Kishikawa T, Takata A, Ohno M, Shibata C, Kang YJ, Yoshida H, Koike K.
    • Journal Title

      PLoS One.

      Volume: 8(9) Issue: 9 Pages: e71969-e71969

    • DOI

      10.1371/journal.pone.0071969

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Inhibition of microRNA122 decreases SREBP1 expression by modulating suppressor of cytokine signaling 3 expression.2013

    • Author(s)
      Shibata C, Kishikawa T, Otsuka M, Ohno M, Yoshikawa T, Takata A, Yoshida H, Koike K.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 438(1) Issue: 1 Pages: 230-5

    • DOI

      10.1016/j.bbrc.2013.07.064

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Perihepatic lymph node enlargement is a negative predictor for sustained responses to pegylated interferon-α and ribavirin therapy for Japanese patients infected with hepatitis C virus genotype 1.2013

    • Author(s)
      Yoshida H et al. (16人中4番目)
    • Journal Title

      Hepatol Res.

      Volume: Epub Issue: 10 Pages: 1005-1012

    • DOI

      10.1111/hepr.12061

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Meta-analysis: mortality and serious adverse events of peginterferon plus ribavirin therapy for chronic hepatitis C.2013

    • Author(s)
      Yoshida H et al. (6人中5番目)
    • Journal Title

      J Gastroenterol.

      Volume: 48 Issue: 2 Pages: 254-68

    • DOI

      10.1007/s00535-012-0631-y

    • NAID

      10031156311

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Silencing of microRNA-122 enhances interferon- α signaling in the liver through regulating SOCS3 promoter methylation2012

    • Author(s)
      Otsuka M
    • Journal Title

      Sci Rep

      Volume: 2 Issue: 1 Pages: 637-637

    • DOI

      10.1038/srep00637

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] MicroRNA-140 acts as a liver tumor suppressor by controlling NF-κB activity by directly targeting DNA methyltransferase 1 (Dnmt1) expression2012

    • Author(s)
      Otsuka M
    • Journal Title

      Hepatology

      Volume: 57 Issue: 1 Pages: 162

    • DOI

      10.1002/hep.26011

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Increased activity of serum mitochondrial isoenzyme of creatine kinase in hepatocellular carcinoma patients predominantly with recurrence2012

    • Author(s)
      Soroida Y, Ohkawa R, Nakagawa H, Satoh Y, Yoshida H, Kinoshita H, Tateishi R, Masuzaki R, Enooku K, Shiina S, Sato T, Obi S, Hoshino T, Nagatomo R, Okubo S, Yokota H, Koike K, Yatomi Y, Ikeda H
    • Journal Title

      J Hepatol

      Volume: 57 Issue: 2 Pages: 330

    • DOI

      10.1016/j.jhep.2012.03.012

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Remarks] 研究グループのホームページ

    • URL

      https://sites.google.com/site/225kenncrna/

    • Related Report
      2013 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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