| Project/Area Number |
24590957
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
KAKINUMA Sei 東京医科歯科大学, 医歯(薬)学総合研究科, 講師 (30372444)
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| Co-Investigator(Kenkyū-buntansha) |
ASAHINA Yasuhiro 東京医科歯科大学, 大学院医歯学総合研究科, 寄附講座教授 (00422692)
WATANABE Mamoru 東京医科歯科大学, 大学院医歯学総合研究科, 教授 (10175127)
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| Co-Investigator(Renkei-kenkyūsha) |
KAMIYA Akihide 東海大学, 創造科学技術研究機構, 准教授 (30321904)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 発生・分化 / 移植 / 再生医学 / 肝疾患治療 / 細胞・組織 |
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| Outline of Final Research Achievements |
Investigators of this research project have studied on the molecular mechanisms regulating differentiation and proliferation of primary hepatic stem/progenitor cells purified by cell surface markers and therapeutic efficacy of transplantation using hepatic stem/progenitor cells. We found that Wnt5a and Wnt5a-related signaling control the biliary differentiation of hepatic stem/progenitor cells. Next, our data indicated that MMP14 and MMP14-related signaling regulate luminal formation of bile ducts in developing liver, and that expression of MMP14 improves the efficacy of transplantation using hepatic stem/progenitor cells. These studies contribute to the progress of regenerative medical science and development of autologous stem cell therapy against chronic liver diseases.
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