| Project/Area Number |
24590959
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
AZUMA Seishin 東京医科歯科大学, 医学部附属病院, 助教 (10376783)
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| Co-Investigator(Kenkyū-buntansha) |
KAKINUMA Sei 東京医科歯科大学, 大学院医歯学総合研究科, 寄付講座講師 (30372444)
ASAHINA Yasuhiro 東京医科歯科大学, 大学院医歯学総合研究科, 寄付講座教授 (00422692)
WATANABE Mamoru 東京医科歯科大学, 大学院医歯学総合研究科, 教授 (10175127)
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| Co-Investigator(Renkei-kenkyūsha) |
SAKAMOTO Naoya 北海道大学, 医学研究科, 教授 (10334418)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 移植 / 発生・分化 / 再生医学 / 肝疾患治療 / 細胞・組織 |
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| Outline of Final Research Achievements |
Investigators of this research project have studied on the molecular mechanisms regulating differentiation and proliferation of hepatic stem/progenitor cells. Based on the results of above-mentioned analysis, we tried to establish the mouse model of chimeric liver using directly reprogrammed hepatocyte-like cells. We found that Wnt5a and Wnt5a-related molecules control the biliary differentiation of hepatic stem/progenitor cells. Next, our data indicated that MMP14 and MMP14-related molecules regulate luminal formation of bile ducts in developing liver, and that expression of MMP14 improves the efficacy of transplantation using hepatic stem/progenitor cells. These studies contribute to the progress of drug discovery for viral hepatitis using mouse model of cell-transplanted chimeric liver in future.
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