Importance of NK cell function in the mechanisms responsible for tumor evasion of immune surveillance against hepatocellular carcinoma after liver transplantation
| Project/Area Number |
24590963
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAKAMURA Masaaki 新潟大学, 医歯学総合病院, 特任助教 (20422602)
MATSUDA Yasunobu 新潟大学, 医歯学系, 准教授 (40334669)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | NK細胞 / 肝癌 / 肝移植 / 免疫監視 / 肝細胞癌 |
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| Outline of Final Research Achievements |
We analysed mainly the function of natural killer (NK) cells in the liver and blood of patients with hepatocellular carcinoma (HCC) before and after liver transplantation (LT), but any specific immune markers associated with the recurrence of HCC after LT could not be defined. However, we revealed that anti-NK cell activation ligand antibody and soluble immune checkpoint molecule were detected in the blood of patients with HCC. Our results may help unveiling the mechanisms responsible for tumor evasion of immune surveillance against HCC.
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Report
(4 results)
Research Products
(14 results)
