The role of PKR and its modification to the function of host cell in hepatocellular carcinoma

• Project/Area Number: 24590980
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Ehime University
• Principal Investigator: HIASA Yoichi 愛媛大学, 医学(系)研究科(研究院), 教授 (70314961)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: PKR / 肝細胞癌 / 細胞増殖 / C型肝炎ウイルス / MAPK / c-Jun / c-Fos / JNK / リン酸化c-Jun / リン酸化c-Fos / Erk / Protein kinase R / MAP kinase

Outline of Final Research Achievements

We previously reported that protein kinase RNA-depended (PKR) is overexpressed in hepatocellular carcinoma (HCC) with hepatitis C virus (HCV) infection, as compared with surrounding non-HCC tissues. Cell proliferation significantly increased by PKR expression, moreover that was dependent on PKR-modulated c-Fos and c-Jun expression in the HCV-replicating cell lines. We also confirmed the coordinate expression of c-Fos and c-Jun with PKR in human HCC specimens. These findings suggest that the overexpressed PKR would some roles for proliferation of HCC, and could be one of the targeted molecules to treat the HCC related with HCV.

Research Products

• [Journal Article] Nonalcoholic fatty liver disease: portal hypertension due to outflow block in patients without cirrhosis. (2015)
  • Author(s): Hirooka M, Koizumi Y, Miyake T, Ochi H, Tokumoto Y, Tada F, Matsuura B, Abe M, Hiasa Y.
  • Journal Title: Radiology Volume: 274 Issue: 2 Pages: 597-604
  • DOI: 10.1148/radiol.14132952
  • Peer Reviewed
• [Journal Article] Significance of exercise in nonalcoholic fatty liver disease in men: a community-based large cross-sectional study. (2015)
  • Author(s): Miyake T, Kumagi T, Hirooka M, Furukawa S, Kawasaki K, Koizumi M, Todo Y, Yamamoto S, Nunoi H, Tokumoto Y, Ikeda Y, Abe M, Kitai K, Matsuura B, Hiasa Y.
  • Journal Title: J Gastroenterol Volume: 50 Issue: 2 Pages: 230-237
  • DOI: 10.1007/s00535-014-0959-6
  • Peer Reviewed / Open Access
• [Journal Article] Pancreatic congestion in liver cirrhosis correlates with impaired insulin secretion. (2014)
  • Author(s): Kuroda T, Hirooka M, Koizumi M, Ochi H, Hisano Y, Bando K, Matsuura B, Kumagi T, Hiasa Y.
  • Journal Title: J Gastroenterol Volume: Epub Issue: 6 Pages: 583-9
  • DOI: 10.1007/s00535-014-1001-8
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Hyperuricemia is a risk factor for the onset of impaired fasting glucose in men with a high plasma glucose level: a community-based study. (2014)
  • Author(s): Miyake T, Kumagi T, Furukawa S, Hirooka M, Kawasaki K, Koizumi M, Todo Y, Yamamoto S, Abe M, Kitai K, Matsuura B, Hiasa Y.
  • Journal Title: PLoS ONE Volume: 9 Issue: 9 Pages: e107882-e107882
  • DOI: 10.1371/journal.pone.0107882
  • Peer Reviewed / Open Access
• [Journal Article] Short sleep duration reduces the risk of nonalcoholic fatty liver disease onset in men: a community-based longitudinal cohort study. (2014)
  • Author(s): Miyake T, Kumagi T, Furukawa S, Hirooka M, Kawasaki K, Koizumi M, Todo Y, Yamamoto S, Tokumoto Y, Ikeda Y, Abe M, Kitai K, Matsuura B, Hiasa Y.
  • Journal Title: J Gastroenterol Volume: Epub Issue: 5 Pages: 583-9
  • DOI: 10.1007/s00535-014-0989-0
  • Peer Reviewed / Open Access
• [Journal Article] New susceptibility and resistance HLA-DP alleles to HBV-related diseases identified by a trans-ethnic association study in Asia. (2014)
  • Author(s): Nishida N, Sawai H, Kashiwase K, Minami M, Sugiyama M, Seto WK, Yuen MF, Posuwan N, Poovorawan Y, Ahn SH, Han KH, Matsuura K, Tanaka Y, Kurosaki M, Asahina Y, Izumi N, Kang JK, （省略）, Tokunaga K, and Mizokami M
  • Journal Title: PLoS One Volume: 9 Issue: 2 Pages: e86449-e86449
  • DOI: 10.1371/journal.pone.0086449
  • Peer Reviewed / Open Access
• [Journal Article] Interleukin 28B polymorphism predicts interferon plus ribavirin treatment outcome in patients with hepatitis C virus-related liver cirrhosis: A multicenter retrospective study in Japan. (2014)
  • Author(s): Shakado S, Sakisaka S, Okanoue T, Chayama K, Izumi N, Toyoda J, Tanaka E, Ido A, Takehara T, Yoshioka K, Hiasa Y, Nomura H, Seike M, Ueno Y, Kumada H.
  • Journal Title: Hepatol Res Volume: 44 Issue: 9 Pages: 983-992
  • DOI: 10.1111/hepr.12280
  • Peer Reviewed / Open Access
• [Journal Article] 18F-FDG-PET/CT predicts the distribution of microsatellite lesions in hepatocellular carcinoma. (2014)
  • Author(s): Ochi H, Hirooka M, Hiraoka A, Koizumi Y, Abe M, Sogabe I, Ishimaru Y, Furuya K, Miyagawa M, Kawasaki H, Michitaka K, Takada Y, Mochizuki T, Hiasa Y.
  • Journal Title: Mol Clin Oncol Volume: 2 Issue: 5 Pages: 798-804
  • DOI: 10.3892/mco.2014.328
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Maximum standardized uptake value in 18F-fluoro-2-deoxyglucose positron emission tomography is associated with advanced tumor factors in esophageal cancer. (2014)
  • Author(s): Kajiwara T, Hiasa Y, Nishina T, Matsumoto T, Hori S, Nadano S, Iguchi H, Takeji S, Tsubouchi E, Ikeda Y, Onji M.
  • Journal Title: Mol Clin Oncol Volume: 2 Issue: 2 Pages: 313-321
  • DOI: 10.3892/mco.2014.238
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Protein kinase R modulates c-Fos and c-Jun signaling to promote proliferation of hepatocellular carcinoma with hepatitis C virus infection. (2013)
  • Author(s): Watanabe T, Hiasa Y, Tokumoto Y, Hirooka M, Abe M, Ikeda Y, Matsuura B, Chung RT, Onji M.
  • Journal Title: PLoS One Volume: 8 Issue: 7 Pages: e67750-e67750
  • DOI: 10.1371/journal.pone.0067750
  • Peer Reviewed
• [Journal Article] Increased B cell-activating factor promotes tumor invasion and metastasis in human pancreatic cancer. (2013)
  • Author(s): Koizumi M, Hiasa Y, Kumagi T, Yamanishi H, Azemoto N, Kobata T, Matsuura B, Abe M, Onji M.
  • Journal Title: PLoS One Volume: 8 Issue: 8 Pages: e71367-e71367
  • DOI: 10.1371/journal.pone.0071367
  • Peer Reviewed
• [Journal Article] Importance of screening for synchronous malignant neoplasms in patients with hepatocellular carcinoma: impact of FDG PET/CT. (2013)
  • Author(s): Hiraoka A, Hirooka M, Ochi H, Koizumi Y, Shimizu Y, Shiraishi A, Yamago H, Tanihira T, Miyata H, Ninomiya T, Kawasaki H, Ishimaru Y, Sogabe I, Inoue T, Abe M, Hiasa Y, Matsuura B, Onji M, Michitaka K.
  • Journal Title: Liver Int. Volume: 33 Issue: 7 Pages: 1085-91
  • DOI: 10.1111/liv.12161
  • Peer Reviewed
• [Journal Article] Des-gamma-carboxy prothrombin identified by P-11 and P-16 antibodies reflects prognosis for patients with hepatocellular carcinoma. (2013)
  • Author(s): Takeji S, Hirooka M, Koizumi Y, Tokumoto Y, Abe M, Ikeda Y, Nadano S, Hiasa Y, Onji M.
  • Journal Title: J Gastroenterol Hepatol Volume: 28 Issue: 4 Pages: 671-7
  • DOI: 10.1111/jgh.12076
  • Peer Reviewed
• [Journal Article] Wilms' tumor 1 gene modulates Fas-related death signals and anti-apoptotic functions in hepatocellular carcinoma. (2013)
  • Author(s): Uesugi K, Hiasa Y, Tokumoto Y, Mashiba T, Koizumi Y, Hirooka M, Abe M, Matsuura B, Onji M.
  • Journal Title: J Gastroenterol Volume: 48 Issue: 9 Pages: 1069-80
  • DOI: 10.1007/s00535-012-0708-7
  • Peer Reviewed
• [Journal Article] Blockade of B-cell-activating factor signaling enhances hepatic steatosis induced by a high-fat diet and improves insulin sensitivity. (2013)
  • Author(s): Kasawaki K, Abe M, Tada F, Tokumoto Y, Chen S, Miyake T, Furukawa S, Matsuura B, Hiasa Y, Onji M.
  • Journal Title: Laboratory Investigation Volume: 93 Issue: 3 Pages: 311-321
  • DOI: 10.1038/labinvest.2012.176
  • Peer Reviewed
• [Journal Article] B cell activating factor in obesity is regulated by oxidative stress in adipocytes (2013)
  • Author(s): Tada F, Abe M, Kawasaki K, Miyake T, Shiyi C, Hiasa Y, Matsuura B, Onji M.
  • Journal Title: Journal of Clinical Biochemistry and Nutrition Volume: 52 Issue: 2 Pages: 120-127
  • DOI: 10.3164/jcbn.12-115
  • NAID: 130004466705
  • ISSN: 0912-0009, 1880-5086
  • Peer Reviewed
• [Journal Article] Oral administration of carbonic anhydrase I ameliorates murine experimental colitis induced by Foxp3-CD4+CD25- T cells. (2013)
  • Author(s): Mori K, Yamanishi H, Ikeda Y, Kumagi T, Hiasa Y, Matsuura B, Abe M, Onji M.
  • Journal Title: J Leukoc Biol Volume: 93 Issue: 6 Pages: 963-972
  • DOI: 10.1189/jlb.1212612
  • Peer Reviewed
• [Journal Article] Wilms' tumor 1 gene modulates Fas-related death signals and anti-apoptotic functions in hepatocellular carcinoma. (2013)
  • Author(s): Uesugi K, Hiasa Y, Tokumoto Y, Mashiba T, Koizumi Y, Hirooka M, Abe M, Matsuura B, Onji M.
  • Journal Title: J Gastroenterol. Volume: in press
  • Peer Reviewed
• [Journal Article] FGF3/FGF4 amplification and multiple lung metastases in responders to sorafenib in hepatocellular carcinoma. (2013)
  • Author(s): Arao T, Ueshima K, Matsumoto K, Nagai T, Kimura H, Hagiwara S, Sakurai T, Haji S, Kanazawa A, Hidaka H, Iso Y, Kubota K, Shimada M, Utsunomiya T, Hirooka M, Hiasa Y, Toyoki Y, Hakamada K, Yasui K, Kumada T, Toyoda H, Sato S, Hisai H, Kuzuya T, Tsuchiya K, Izumi N, Arii S, Nishio K, Kudo M.
  • Journal Title: Hepatology Volume: 57 Issue: 4 Pages: 1407-1415
  • DOI: 10.1002/hep.25956
  • Peer Reviewed
• [Journal Article] Inhibition of hepatocellular carcinoma by PegIFNα2a in patients with chronic hepatitis C: a nationwide multi-center cooperative study. (2013)
  • Author(s): Izumi N, Asahina Y, Kumada H et al
  • Journal Title: J Gastroenterol Volume: 48 Issue: 3 Pages: 382-390
  • DOI: 10.1007/s00535-012-0641-9
  • Peer Reviewed
• [Journal Article] High Serum Palmitic Acid is Associated with Low Antiviral Effects of Interferon-Based Therapy for Hepatitis C Virus. (2012)
  • Author(s): Miyake T, Hiasa Y, Hirooka M, Tokumoto Y, Watanabe T, Furukawa S, Ueda T, Yamamoto S, Kumagi T, Miyaoka H, Abe M, Matsuura B, Onji M.
  • Journal Title: Lipids Volume: 47 Issue: 11 Pages: 1053-1062
  • DOI: 10.1007/s11745-012-3716-8
  • Peer Reviewed
• [Journal Article] Phase I/II study of immunotherapy using tumor antigen-pulsed dendritic cells in patients with hepatocellular carcinoma. (2012)
  • Author(s): Tada F, Abe M, Hirooka M, Ikeda Y, Hiasa Y, Lee Y, Jung NC, Lee WB, Lee HS, Bae YS, Onji M.
  • Journal Title: Int J Oncol. Volume: 41 Issue: 5 Pages: 1601-1609
  • DOI: 10.3892/ijo.2012.1626
  • Peer Reviewed
• [Journal Article] Lymphotoxin β Receptor Signaling Promotes Development of Autoimmune Pancreatitis. (2012)
  • Author(s): Seleznik GM, Reding T, Romrig F,…… Kumagi T, et al.
  • Journal Title: Gastroenterology Volume: 143 Issue: 5 Pages: 1361-1374
  • DOI: 10.1053/j.gastro.2012.07.112
  • Peer Reviewed
• [Journal Article] Rapid alternative absorption of dietary long-chain fatty acids with upregulation of intestinal glycosylated CD36 in liver cirrhosis. (2012)
  • Author(s): Yamamoto Y, Hiasa Y, Murakami H, Ikeda Y, Yamanishi H, Abe M, Matsuura B, Onji M.
  • Journal Title: Am J Clin Nutr. Volume: 96 Issue: 1 Pages: 90-101
  • DOI: 10.3945/ajcn.111.033084
  • Peer Reviewed
• [Journal Article] Real-time tissue elastography for evaluation of hepatic fibrosis and portal hypertension in nonalcoholic fatty liver diseases. (2012)
  • Author(s): Ochi H, Hirooka M, Koizumi Y, Miyake T, Tokumoto Y, Soga Y, Tada F, Abe M, Hiasa Y, Onji M.
  • Journal Title: Hepatology Volume: 56 Issue: 4 Pages: 1271-1278
  • DOI: 10.1002/hep.25756
  • Peer Reviewed
• [Journal Article] Ribavirin regulates hepatitis C virus replication through enhancing interferon-stimulated genes and interleukin 8 (2012)
  • Author(s): Tokumoto Y, Hiasa Y, Uesugi K, 他7名、2番目
  • Journal Title: Journal of Infectious Diseases Volume: 205 Issue: 7 Pages: 1121-1130
  • DOI: 10.1093/infdis/jis025
  • Peer Reviewed
• [Journal Article] Regulatory Dendritic Cells Pulsed with Carbonic Anhydrase I Protect Mice from Colitis Induced by CD4+CD25− T Cells. (2012)
  • Author(s): Yamanishi H, Murakami H, Ikeda Y, Kumagi T, Hiasa Y, Abe M, Matsuura B, Onji M.
  • Journal Title: J Immunol Volume: 188 Issue: 5 Pages: 2164-2172
  • DOI: 10.4049/jimmunol.1100559
  • Peer Reviewed
• [Presentation] Portal hypertension due to outflow block in non-cirrhotic patients with nonalcoholic fatty liver disease. (2014)
  • Author(s): Koizumi Y, Hirooka M, Hiasa Y, et al.
  • Organizer: The 65th Annual Meeting of the American Association for the Study of Liver Diseases
  • Place of Presentation: Boston, USA
  • Year and Date: 2014-11-07 – 2014-11-11
• [Presentation] Branched-chain amino acids improve intestinal malabsorption of dietary long-chain fatty acids and preserve intestinal fatty acid transporters in liver cirrhosis. (2014)
  • Author(s): Yamamoto Y, Utsunomiya H, Hiasa Y, et al.
  • Organizer: The 65th Annual Meeting of the American Association for the Study of Liver Diseases
  • Place of Presentation: Boston, USA
  • Year and Date: 2014-11-07 – 2014-11-11
• [Presentation] Pancreatic congestion in liver cirrhosis correlates with impaired insulin secretion. (2014)
  • Author(s): Kuroda T, Hirooka M, Hiasa Y, et al.
  • Organizer: The 65th Annual Meeting of the American Association for the Study of Liver Diseases
  • Place of Presentation: Boston, USA
  • Year and Date: 2014-11-07 – 2014-11-11
• [Presentation] Wisteria floribunda agglutinin-positive Mac-2 binding protein as a predictor of liver fibrosis in patients with non-alcoholic fatty liver disease. (2014)
  • Author(s): Abe M, Miyake T, Hiasa Y, et al.
  • Organizer: The 65th Annual Meeting of the American Association for the Study of Liver Diseases
  • Place of Presentation: Boston, USA
  • Year and Date: 2014-11-07 – 2014-11-11
• [Presentation] Oral glucose tolerance test predicts hepatic fibrosis in nonalcoholic fatty liver disease patients without overt diabetes mellitus. (2014)
  • Author(s): Nishina S, Hyogo H, Hiasa Y, et al.
  • Organizer: The 65th Annual Meeting of the American Association for the Study of Liver Diseases
  • Place of Presentation: Boston, USA
  • Year and Date: 2014-11-07 – 2014-11-11
• [Presentation] 治療前CTHA後期相を用いたfusion CTによる肝細胞癌局所療法治療効果判定 (2013)
  • Author(s): 廣岡昌史、小泉洋平、日浅陽一
  • Organizer: 第49回日本肝臓学会総会
  • Place of Presentation: 東京 京王プラザホテル
• [Presentation] IgG4関連疾患診断における巻組織検査の有用性 (2013)
  • Author(s): 熊木天児、日浅陽一、恩地森一
  • Organizer: 第49回日本肝臓学会総会
  • Place of Presentation: 東京 京王プラザホテル
• [Presentation] 新たなPIVKA-II分画(NX-PVKA)の肝癌患者予後予測における臨床的有用性 (2013)
  • Author(s): 竹治智、廣岡昌史、日浅陽一
  • Organizer: 第17回日本肝臓学会大会
  • Place of Presentation: 東京 グランドプリンス新高輪
• [Presentation] Protein kinase R modulates c-Fos and c-Jun signaling to promote proliferation of hepatocellular carcinoma with hepatitis C virus infection (2013)
  • Author(s): Takao Watanabe, Yoshio Tokumoto, Masashi Hirooka, Masanori Abe, Morikazu Onji, Raymond T. Chung, Yoichi Hiasa
  • Organizer: The 64th Annual Meeting of the American Association for the Study of Liver Diseases
  • Place of Presentation: Washington DC, USA
• [Presentation] Nature of pathogenic and protective immunity in chronic hepatitis B virus infection (2013)
  • Author(s): Sheikh Mohammad Fazle Akbar, Mamun A. Mahtab, Yoichi Hiasa, Julio Cesar Aguilar
  • Organizer: The 64th Annual Meeting of the American Association for the Study of Liver Diseases
  • Place of Presentation: Washington DC, USA
• [Presentation] Trans-ethnic analyses of HLA-DPA1, DPB1 haplotypes to be associated with hepatitis B virus infection (2013)
  • Author(s): Nao Nishida, Hiromi Sawai, Kouichi Kashiwase, Mutsuhiko Minami, Yoichi Hiasa, et al.
  • Organizer: The 64th Annual Meeting of the American Association for the Study of Liver Diseases
  • Place of Presentation: Washington DC, USA
• [Presentation] A phase III clinical trial with a therapeutic vaccine containing both HBsAg and HBcAg administered via both mucosal and parenteral routes in patients with chronic hepatitis B (2013)
  • Author(s): Sheikh Mohammad Fazle Akbar, Mamun A. Mahtab, Salimur Rahman, Julio Cesar Aguilar, Yoichi Hiasa, Shunji Mishiro
  • Organizer: The 64th Annual Meeting of the American Association for the Study of Liver Diseases
  • Place of Presentation: Washington DC, USA
• [Presentation] Virtual ultrasonography constructed by Gd-EOB- DTPA-enhanced magnetic resonance imaging is useful to avoid bile duct injury during radiofrequency ablatio (2013)
  • Author(s): Yohei Koizumi, Masashi Hirooka, Hironori Ochi, Yoshio Tokumoto, Masanori Abe, Fujimasa Tada, Atsushi Hiraoka, Hiroaki Tanaka, Takaharu Tsuda, Teruhito Mochizuki, Yoichi Hiasa
  • Organizer: The 64th Annual Meeting of the American Association for the Study of Liver Diseases
  • Place of Presentation: Washington DC, USA
• [Presentation] Rapid absorption of dietary long-chain fatty acids with changes to intestinal fatty acid transporters in liver cirrhosis (2013)
  • Author(s): Yasunori Yamamoto, Yoshio Ikeda, Eiji Tsubouchi, Hiroki Utsunomiya, Miyake Teruki, Hiroaki Nunoi, Morikazu Onji, Bunzo Matsuura, Yoichi Hiasa
  • Organizer: The 64th Annual Meeting of the American Association for the Study of Liver Diseases
  • Place of Presentation: Washington DC, USA
• [Presentation] Insertion of LINE-1 retrotranspozon in SLCO1B3 gene causes Rotor syndrome in Japanese patients (2013)
  • Author(s): Tatehiro Kagawa, Kazuya Anzai, Kota Tsuruya, Yoshitaka Arase, Shunji Hirose, Koichi Shiraishi, Tsuneo Kitamura, Yoshinao Kobayashi, Yoichi Hiasa, Tetsuya Mine
  • Organizer: The 64th Annual Meeting of the American Association for the Study of Liver Diseases
  • Place of Presentation: Washington DC, USA
• [Presentation] Composition of serum fatty acids may be associated with the antiviral effects of interferon-based therapy in patients with hepatitis C virus infection (2013)
  • Author(s): Teruki Miyake, Masashi Hirooka, Yoshio Tokumoto, Takao Watanabe, Teru Kumagi, Masanori Abe, Shinya Furukawa, Morikazu Onji, Bunzo Matsuura, Yoichi Hiasa
  • Organizer: The 64th Annual Meeting of the American Association for the Study of Liver Diseases
  • Place of Presentation: Washington DC, USA
• [Presentation] An isoform of des-gamma-carboxy prothrombin (NX-PVKA) is a prognostic marker of hepatocellular carcinoma (2013)
  • Author(s): Satoru Takeji, Masashi Hirooka, Yohei Koizumi, Hironori Ochi, Yoshio Tokumoto, Fujimasa Tada, Masanori Abe, Morikazu Onji, Yoichi Hiasa
  • Organizer: The 64th Annual Meeting of the American Association for the Study of Liver Diseases
  • Place of Presentation: Washington DC, USA
• [Presentation] 新しいPIVKA-II分画(NX-PVKA)の肝細胞癌患者予後との関連 (2013)
  • Author(s): 竹治智、廣岡昌史、日浅陽一
  • Organizer: 第99回 日本消化器病学会総会
  • Place of Presentation: 鹿児島県鹿児島市
• [Presentation] 肝細胞癌に対する抗原パルス樹状細胞を用いた免疫療法の第I/II相臨床試験 (2012)
  • Author(s): 阿部雅則、多田藤政、廣岡昌史、小泉洋平、日浅陽一、恩地森一
  • Organizer: 第48回 日本肝臓学会総会
  • Place of Presentation: 石川県金沢市
• [Presentation] 薬物性肝障害の実態 (2012)
  • Author(s): 堀池典生、上杉和寛、日浅陽一
  • Organizer: 第16回 日本肝臓学会大会
  • Place of Presentation: 兵庫県神戸市
• [Presentation] 肝硬変患者における脂肪酸吸収変化とglycosylated CD36の役割 (2012)
  • Author(s): 山本安則、池田宜央、日浅陽一
  • Organizer: 第98回 日本消化器病学会総会
  • Place of Presentation: 東京都新宿区
• [Presentation] NAFLDの肝線維化診断におけるReal-time tissue elastographyの有用性の検討 (2012)
  • Author(s): 越智裕紀、廣岡昌史、日浅陽一
  • Organizer: 第54回 日本消化器病学会大会
  • Place of Presentation: 兵庫県神戸市
• [Book] Bio Clinica 「7 DAAによる治療困難例への挑戦、肝移植例 他」 (2013)
  • Author(s): 徳本良雄、日浅陽一
  • Total Pages: 6
  • Publisher: 北隆館
• [Book] 新薬展望2014「消化器疾患治療薬」 (2013)
  • Author(s): 廣岡昌史、池田宜央、日浅陽一
  • Total Pages: 7
  • Publisher: 医薬ジャーナル社
• [Book] Dendritic Cell-Based Immune Therapy in Liver Diseases. (2012)
  • Author(s): Akbar SMF, Hiasa Y, Mahtab MAI, Onji M
  • Total Pages: 9
  • Publisher: Curr Immunol Rev
• [Book] Dendritic Cells in Autoimmune Liver Diseases. (2012)
  • Author(s): Abe M, Hiasa Y, Onji M
  • Total Pages: 5
  • Publisher: Curr Immunol Rev
• [Book] 愛媛大学における急性肝炎症例の解析 わが国における急性肝炎の現状 全国調査2008-2011 (2012)
  • Author(s): 徳本良雄、渡辺崇夫、多田藤政、上杉和寛、眞柴寿枝、重松秀一郎、阿部雅則、日浅陽一、恩地森一
  • Total Pages: 11
  • Publisher: 中外医学社
• [Patent(Industrial Property Rights)] 体内での針先端を画像上に表示する針先端画像表示装置、それを用いたがん治療装置および体内での針先端を画像上に表示する針先端画像表示方法 (2014)
  • Inventor(s): 廣岡昌史、日浅陽一
  • Industrial Property Rights Holder: 廣岡昌史、日浅陽一
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2014-086806
  • Filing Date: 2014-04-18
• [Patent(Industrial Property Rights)] ROMスコア及び肝細胞癌患者の客観的な予後予測方法 (2012)
  • Inventor(s): 竹治智、日浅陽一、廣岡昌史、恩地森一
  • Industrial Property Rights Holder: 竹治智、日浅陽一、廣岡昌史、恩地森一
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2012-273601
  • Filing Date: 2012-12-14