The role of PKR and its modification to the function of host cell in hepatocellular carcinoma
Project/Area Number |
24590980
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Gastroenterology
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Research Institution | Ehime University |
Principal Investigator |
HIASA Yoichi 愛媛大学, 医学(系)研究科(研究院), 教授 (70314961)
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Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | PKR / 肝細胞癌 / 細胞増殖 / C型肝炎ウイルス / MAPK / c-Jun / c-Fos / JNK / リン酸化c-Jun / リン酸化c-Fos / Erk / Protein kinase R / MAP kinase |
Outline of Final Research Achievements |
We previously reported that protein kinase RNA-depended (PKR) is overexpressed in hepatocellular carcinoma (HCC) with hepatitis C virus (HCV) infection, as compared with surrounding non-HCC tissues. Cell proliferation significantly increased by PKR expression, moreover that was dependent on PKR-modulated c-Fos and c-Jun expression in the HCV-replicating cell lines. We also confirmed the coordinate expression of c-Fos and c-Jun with PKR in human HCC specimens. These findings suggest that the overexpressed PKR would some roles for proliferation of HCC, and could be one of the targeted molecules to treat the HCC related with HCV.
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Report
(4 results)
Research Products
(56 results)
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[Journal Article] Significance of exercise in nonalcoholic fatty liver disease in men: a community-based large cross-sectional study.2015
Author(s)
Miyake T, Kumagi T, Hirooka M, Furukawa S, Kawasaki K, Koizumi M, Todo Y, Yamamoto S, Nunoi H, Tokumoto Y, Ikeda Y, Abe M, Kitai K, Matsuura B, Hiasa Y.
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Journal Title
J Gastroenterol
Volume: 50
Issue: 2
Pages: 230-237
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Hyperuricemia is a risk factor for the onset of impaired fasting glucose in men with a high plasma glucose level: a community-based study.2014
Author(s)
Miyake T, Kumagi T, Furukawa S, Hirooka M, Kawasaki K, Koizumi M, Todo Y, Yamamoto S, Abe M, Kitai K, Matsuura B, Hiasa Y.
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Journal Title
PLoS ONE
Volume: 9
Issue: 9
Pages: e107882-e107882
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Short sleep duration reduces the risk of nonalcoholic fatty liver disease onset in men: a community-based longitudinal cohort study.2014
Author(s)
Miyake T, Kumagi T, Furukawa S, Hirooka M, Kawasaki K, Koizumi M, Todo Y, Yamamoto S, Tokumoto Y, Ikeda Y, Abe M, Kitai K, Matsuura B, Hiasa Y.
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Journal Title
J Gastroenterol
Volume: Epub
Issue: 5
Pages: 583-9
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] New susceptibility and resistance HLA-DP alleles to HBV-related diseases identified by a trans-ethnic association study in Asia.2014
Author(s)
Nishida N, Sawai H, Kashiwase K, Minami M, Sugiyama M, Seto WK, Yuen MF, Posuwan N, Poovorawan Y, Ahn SH, Han KH, Matsuura K, Tanaka Y, Kurosaki M, Asahina Y, Izumi N, Kang JK, (省略), Tokunaga K, and Mizokami M
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Journal Title
PLoS One
Volume: 9
Issue: 2
Pages: e86449-e86449
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Interleukin 28B polymorphism predicts interferon plus ribavirin treatment outcome in patients with hepatitis C virus-related liver cirrhosis: A multicenter retrospective study in Japan.2014
Author(s)
Shakado S, Sakisaka S, Okanoue T, Chayama K, Izumi N, Toyoda J, Tanaka E, Ido A, Takehara T, Yoshioka K, Hiasa Y, Nomura H, Seike M, Ueno Y, Kumada H.
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Journal Title
Hepatol Res
Volume: 44
Issue: 9
Pages: 983-992
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] 18F-FDG-PET/CT predicts the distribution of microsatellite lesions in hepatocellular carcinoma.2014
Author(s)
Ochi H, Hirooka M, Hiraoka A, Koizumi Y, Abe M, Sogabe I, Ishimaru Y, Furuya K, Miyagawa M, Kawasaki H, Michitaka K, Takada Y, Mochizuki T, Hiasa Y.
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Journal Title
Mol Clin Oncol
Volume: 2
Issue: 5
Pages: 798-804
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Maximum standardized uptake value in 18F-fluoro-2-deoxyglucose positron emission tomography is associated with advanced tumor factors in esophageal cancer.2014
Author(s)
Kajiwara T, Hiasa Y, Nishina T, Matsumoto T, Hori S, Nadano S, Iguchi H, Takeji S, Tsubouchi E, Ikeda Y, Onji M.
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Journal Title
Mol Clin Oncol
Volume: 2
Issue: 2
Pages: 313-321
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Importance of screening for synchronous malignant neoplasms in patients with hepatocellular carcinoma: impact of FDG PET/CT.2013
Author(s)
Hiraoka A, Hirooka M, Ochi H, Koizumi Y, Shimizu Y, Shiraishi A, Yamago H, Tanihira T, Miyata H, Ninomiya T, Kawasaki H, Ishimaru Y, Sogabe I, Inoue T, Abe M, Hiasa Y, Matsuura B, Onji M, Michitaka K.
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Journal Title
Liver Int.
Volume: 33
Issue: 7
Pages: 1085-91
DOI
Related Report
Peer Reviewed
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[Journal Article] FGF3/FGF4 amplification and multiple lung metastases in responders to sorafenib in hepatocellular carcinoma.2013
Author(s)
Arao T, Ueshima K, Matsumoto K, Nagai T, Kimura H, Hagiwara S, Sakurai T, Haji S, Kanazawa A, Hidaka H, Iso Y, Kubota K, Shimada M, Utsunomiya T, Hirooka M, Hiasa Y, Toyoki Y, Hakamada K, Yasui K, Kumada T, Toyoda H, Sato S, Hisai H, Kuzuya T, Tsuchiya K, Izumi N, Arii S, Nishio K, Kudo M.
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Journal Title
Hepatology
Volume: 57
Issue: 4
Pages: 1407-1415
DOI
Related Report
Peer Reviewed
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[Journal Article] High Serum Palmitic Acid is Associated with Low Antiviral Effects of Interferon-Based Therapy for Hepatitis C Virus.2012
Author(s)
Miyake T, Hiasa Y, Hirooka M, Tokumoto Y, Watanabe T, Furukawa S, Ueda T, Yamamoto S, Kumagi T, Miyaoka H, Abe M, Matsuura B, Onji M.
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Journal Title
Lipids
Volume: 47
Issue: 11
Pages: 1053-1062
DOI
Related Report
Peer Reviewed
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[Journal Article] Phase I/II study of immunotherapy using tumor antigen-pulsed dendritic cells in patients with hepatocellular carcinoma.2012
Author(s)
Tada F, Abe M, Hirooka M, Ikeda Y, Hiasa Y, Lee Y, Jung NC, Lee WB, Lee HS, Bae YS, Onji M.
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Journal Title
Int J Oncol.
Volume: 41
Issue: 5
Pages: 1601-1609
DOI
Related Report
Peer Reviewed
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[Presentation] Virtual ultrasonography constructed by Gd-EOB- DTPA-enhanced magnetic resonance imaging is useful to avoid bile duct injury during radiofrequency ablatio2013
Author(s)
Yohei Koizumi, Masashi Hirooka, Hironori Ochi, Yoshio Tokumoto, Masanori Abe, Fujimasa Tada, Atsushi Hiraoka, Hiroaki Tanaka, Takaharu Tsuda, Teruhito Mochizuki, Yoichi Hiasa
Organizer
The 64th Annual Meeting of the American Association for the Study of Liver Diseases
Place of Presentation
Washington DC, USA
Related Report
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[Presentation] Insertion of LINE-1 retrotranspozon in SLCO1B3 gene causes Rotor syndrome in Japanese patients2013
Author(s)
Tatehiro Kagawa, Kazuya Anzai, Kota Tsuruya, Yoshitaka Arase, Shunji Hirose, Koichi Shiraishi, Tsuneo Kitamura, Yoshinao Kobayashi, Yoichi Hiasa, Tetsuya Mine
Organizer
The 64th Annual Meeting of the American Association for the Study of Liver Diseases
Place of Presentation
Washington DC, USA
Related Report
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[Presentation] Composition of serum fatty acids may be associated with the antiviral effects of interferon-based therapy in patients with hepatitis C virus infection2013
Author(s)
Teruki Miyake, Masashi Hirooka, Yoshio Tokumoto, Takao Watanabe, Teru Kumagi, Masanori Abe, Shinya Furukawa, Morikazu Onji, Bunzo Matsuura, Yoichi Hiasa
Organizer
The 64th Annual Meeting of the American Association for the Study of Liver Diseases
Place of Presentation
Washington DC, USA
Related Report
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