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Clinical significance of anti-PEPCK antibody in patients with autoimmune hepatitis

Research Project

Project/Area Number 24590987
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Gastroenterology
Research InstitutionFukushima Medical University

Principal Investigator

OHIRA Hiromasa  福島県立医科大学, 医学部, 教授 (90274951)

Co-Investigator(Kenkyū-buntansha) ABE Kazumichi  福島県立医科大学, 消化器・リウマチ膠原病内科, 教授 (30468128)
WATANABE Hiroshi  福島県立医科大学, 消化器・リウマチ膠原病内科, 教授 (40336467)
TAKAHASHI Atsushi  福島県立医科大学, 消化器・リウマチ膠原病内科, 助教 (40404868)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords自己免疫性肝炎 / PEPCK抗体 / CpGDNA / CpGDNA / ミトコンドリア
Outline of Final Research Achievements

Identifying disease-specific autoantibodies that can be used diagnostically or are involved in the pathogenesis of AIH is important. We extracted non-nuclear component protein from normal human liver cells from which PEPCK was identified as an antigenic protein that specifically reacted with the sera from AIH patients, and we evaluated the clinical significance of anti-PEPCK antibody. The sensitivity, specificity and accuracy of anti-PEPCK antibody in diagnosing AIH were 50.0%, 91.5% and 83.1%, respectively. None of the AIH patients positive for anti-PEPCK antibody showed characteristic clinical features. Although further investigations into the clinical usefulness are necessary, anti-PEPCK may have potential as a diagnostic marker for AIH.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (2 results)

All 2014 2013

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Acknowledgement Compliant: 1 results) Presentation (1 results)

  • [Journal Article] Anti-phosphoenolpyruvate carboxykinase 2 antibody in patients with autoimmune hepatitis.2014

    • Author(s)
      Kanno Y, Watanabe H, Takahashi A, Abe K, Ohira H
    • Journal Title

      Hepatology Research

      Volume: 44 Issue: 9 Pages: 1019-1025

    • DOI

      10.1111/hepr.12276

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 自己免疫性肝炎における抗PEPCK抗体についての検討2013

    • Author(s)
      菅野有紀子、渡辺浩志、岡井研、勝嶋史子、阿部和道、高橋敦史、大平弘正
    • Organizer
      日本肝臓学会総会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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