| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Outline of Final Research Achievements |
To analyze the effects of interferon (IFN)-λ, which has received considerable attention in hepatitis C virus (HCV), the induction of antiviral IFN-stimulated genes (ISGs) was investigated using chronically HCV infected model mice. IFN-λ expression levels by treatment of peg-IFN-α and peg-IFN-λ were significantly induced in HCV-infected human hepatocytes harbouring the favourable IL28B genotype. Moreover, IFN-λ responses against 5’-triphosphate single stranded RNA transfection (mimic of HCV infection) were varied from the host polymorphisms near IL28B. Our results suggest that a response of human hepatocytes against HCV infection could be contribute to type III IFN production and the responses might be depended on the genetic feature near IL28B.
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