Role of hepatoma-derived growth factor in the tumor angiogenesis and the growth of the hepatocellular carcinoma
| Project/Area Number |
24590998
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
IMANISHI HIROYASU 兵庫医科大学, 医学部, 准教授 (60340957)
NISHIGUCHI SHUHEI 兵庫医科大学, 医学部, 教授 (10192246)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | HDGF / 肝細胞癌 / 血管新生 / Sorafenib / IFN / Xenograft model / DNA チップ / 細胞増殖 |
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| Outline of Final Research Achievements |
In the present study, we showed the possibility that IFN treatment amplifies the antitumor effects of sorafenib for hepatocellular carcinoma (HCC). Down-regulation of HDGF shows antitumor effects for HCC through the inhibition of cancer cell proliferation and angiogenesis. We also found that VEGF treatment did not induce HDGF expression, while HDGF induced VEGF expression. These findings revealed new roles of HDGF in HCC growth and angiogenesis, and should contribute to the development of a new therapy for HCC by inhibiting the HDGF function.
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Report
(5 results)
Research Products
(20 results)
