Detection of host factors involved in active HCV replication complex

• Project/Area Number: 24591001
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: National Institute of Infectious Diseases
• Principal Investigator: Aizaki Hideki 国立感染症研究所, その他部局等, その他 (00333360)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: C型肝炎ウイルス / 翻訳・複製調節

Outline of Final Research Achievements

Although several host cellular proteins have been identified as NS5A-binding partners and their significance in the viral replication has been reported, the molecular basis of NS5A in Hepatitis C virus (HCV) life cycle has not been fully understood yet. In this study, to identify novel cellular factors interacting with NS5A, we performed a co-purification, pull-down approach using the cytoplasmic membrane fraction of cells expressing an epitope-tagged NS5A. We identified embryonic lethal, abnormal vision, drosophila-like 1 (ELAVL1) for both viral RNA replication and protein translation. We are going to elucidate the molecular mechanisms that modulate HCV life cycle through interaction between NS5A and host factors identified in our screening system.

Research Products

• [Journal Article] Single-domain intrabodies against HCV Core inhibit viral propagation and Core-induced NF-κB Activation. (2016)
  • Author(s): Suzuki R, Saito K, Matsuda M, Sato M, Kanegae Y, Shi G, Watashi K, Aizaki H, Chiba J, Saito I, Wakita T, Suzuki T.
  • Journal Title: J Gen Virol. Volume: -
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Prolactin regulatory element binding protein is involved in hepatitis C virus replication compartment by interacting with NS4B. (2016)
  • Author(s): Kong L, Fujimoto A, Nakamura M, Aoyagi H, Matsuda M, Watashi K, Suzuki R, Arita M, Yamagoe S, Dohmae N, Suzuki T, Sakamaki Y, Ichinose S, Suzuki T, Wakita T, Aizaki H.
  • Journal Title: J Virol. Volume: 90 Pages: 3093-111
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] A Novel Tricyclic Polyketide, Vanitaracin A, Specifically Inhibits the Entry of Hepatitis B and D Viruses by Targeting Sodium Taurocholate Cotransporting Polypeptide. (2015)
  • Author(s): Kaneko M, Watashi K, Kamisuki S, Matsunaga H, Iwamoto M, Kawai F, Ohashi H, Tsukuda S, Shimura S, Suzuki R, Aizaki H, Sugiyama M, Park SY, Ito T, Ohtani N, Sugawara F, Tanaka Y, Mizokami M, Sureau C, Wakita T.
  • Journal Title: J Virol. Volume: 89 Pages: 11945-53
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Dysregulation of Retinoic Acid Receptor Diminishes Hepatocyte Permissiveness to Hepatitis B Virus Infection through Modulation of NTCP Expression. (2015)
  • Author(s): Tsukuda S, Watashi K, Iwamoto M, Suzuki R, Aizaki H, Okada M, Sugiyama M, Kojima S, Tanaka Y, Mizokami M, Li J, Tong S, Wakita T.
  • Journal Title: J Biol Chem. Volume: 290 Pages: 5673-84
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Targeting cellular squalene synthase, an enzyme essential for cholesterol biosynthesis, is a potential antiviral strategy against hepatitis C virus. (2015)
  • Author(s): Saito K, Shirasago Y, Suzuki T, Aizaki H, Hanada K, Wakita T, Nishijima M, Fukasawa M.
  • Journal Title: J Virol. Volume: 89 Pages: 2220-32
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Production of single-round infectious chimeric flaviviruses with DNA-based Japanese encephalitis virus replicon (2014)
  • Author(s): Suzuki R, Ishikawa T, Konishi E, Matsuda M, Watashi K, Aizaki H, Takasaki T, Wakita T
  • Journal Title: J Gen Virol Volume: 95 Issue: 1 Pages: 60-65
  • DOI: 10.1099/vir.0.058008-0
  • Peer Reviewed / Open Access
• [Journal Article] Alternative endocytosis pathway for productive entry of hepatitis C virus. (2014)
  • Author(s): Matsuda M, Suzuki R, Kataoka C, Watashi K, Aizaki H, Kato N, Matsuura Y, Suzuki T, Wakita T
  • Journal Title: J Gen Virol. Volume: 95(Pt 12) Issue: 12 Pages: 2658-67
  • DOI: 10.1099/vir.0.068528-0
  • Peer Reviewed / Open Access
• [Journal Article] Development of hepatitis C virus genotype 3a cell culture system. (2014)
  • Author(s): Kim S, Date T, Yokokawa H, Kono T, Aizaki H, Maurel P, Gondeau C, Wakita T.
  • Journal Title: Hepatology Volume: 60(6) Issue: 6 Pages: 1838-50
  • DOI: 10.1002/hep.27197
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Involvement of MAP3K8 and miR-17-5p in poor virologic response to interferon-based combination therapy for chronic hepatitis C (2014)
  • Author(s): Tsubota A, Mogushi K, Aizaki H, Miyaguchi K, Nagatsuma K, Matsudaira H, Kushida T, Furihata T, Tanaka H, Matsuura T.
  • Journal Title: PLoS One Volume: 9 Issue: 5 Pages: e97078-e97078
  • DOI: 10.1371/journal.pone.0097078
  • Peer Reviewed / Open Access
• [Journal Article] Evaluation and identification of hepatitis B virus entry inhibitors using HepG2 cells overexpressing a membrane transporter NTCP (2014)
  • Author(s): Iwamoto M, Watashi K, Tsukuda S, Aly HH, Fukasawa M, Fujimoto A, Suzuki R, Aizaki H, Ito T, Koiwai O, Kusuhara H, Wakita T
  • Journal Title: Biochem Biophys Res Commun Volume: 443 Issue: 3 Pages: 808-813
  • DOI: 10.1016/j.bbrc.2013.12.052
  • Peer Reviewed / Open Access
• [Journal Article] Nanoimaging of ssRNA: Genome Architecture of the Hepatitis C Virus Revealed by Atomic Force Microscopy. (2014)
  • Author(s): Gilmore1 JL, Aizaki H, Yoshida1 A, Deguchi K, Kumeta M, Junghof J, Wakita T, Takeyasu K.
  • Journal Title: J Nanomed Nanotechol. Volume: doi:10.4172
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Evaluation and Identification of hepatitis B virus entry inhibitors using HepG2 cells overexpressing a membrane transporter NTCP (2014)
  • Author(s): Iwamoto M, Watashi K, Tsukuda S, Aly1 HH, Fukasawa M, Suzuki R, Aizaki H, Ito T, Koiwai O, Kusuhara H, Wakita T
  • Journal Title: Biochem Biophys Res Commun Volume: 443 Pages: 808-813
  • Peer Reviewed
• [Journal Article] J Gen Virol. (2014)
  • Author(s): Suzuki R, Ishikawa T, Konishi E, Matsuda M, Watashi K, Aizaki H, Takasaki T, Wakita T
  • Journal Title: Production of single-round infectious chimeric flaviviruses with DNA-based Japanese encephalitis virus replicon. Volume: 95 Pages: 60-65
  • Peer Reviewed
• [Journal Article] HCV NS3 protease enhances liver fibrosis via binding to and activating TGF-β type I receptor (2013)
  • Author(s): Sakata K, Hara M, Terada T, Watanabe N, Takaya D, Yaguchi S, Matsumoto T, Matsuura T, Shirouzu M, Yokoyama S, Yamaguchi T, Miyazawa K, Aizaki H, Suzuki T, Wakita T, Imoto M, Kojima S
  • Journal Title: Sci Rep. Volume: 22 Pages: 7-7
  • Peer Reviewed
• [Journal Article] Biochem Biophys Res Commun. (2013)
  • Author(s): Nakajima S, Watashi K, Kamisuki S, Tsukuda S, Takemoto K, Matsuda M, Suzuki R, Aizaki H, Sugawara F, Wakita T
  • Journal Title: Specific inhibition of hepatitis C virus entry into host hepatocytes by fungi-derived sulochrin and its derivatives. Volume: 440 Pages: 515-520
  • Peer Reviewed
• [Journal Article] J Biol Chem. (2013)
  • Author(s): Watashi K, Liang G, Iwamoto M, Marusawa H, Uchida N, Daito T, Kitamura K, Muramatsu M, Ohashi H, Kiyohara T, Suzuki R, Li J, Tong S, Tanaka Y, Murata K, Aizaki H, Wakita T.
  • Journal Title: Interleukin-1 and Tumor Necrosis Factor-α Trigger Restriction of Hepatitis B Virus Infection via a Cytidine Deaminase Activation-induced Cytidine Deaminase (AID). Volume: 288 Pages: 31715-31727
  • Peer Reviewed
• [Journal Article] Signal peptidase complex subunit 1 participates in the assembly of hepatitis C virus through an interaction with E2 and NS2. (2013)
  • Author(s): Suzuki R, Matsuda M, Watashi K, Aizaki H, Matsuura Y, Wakita T, Suzuki T.
  • Journal Title: PLoS Pathog. Volume: 9
  • Peer Reviewed
• [Journal Article] Antiviral activity of glycyrrhizin against hepatitis C virus in vitro. (2013)
  • Author(s): Matsumoto Y, Matsuura T, Aoyagi H, Matsuda M, Hmwe SS, Date T, Watanabe N, Watashi K, Suzuki R, Ichinose S, Wake K, Suzuki T, Miyamura T, Wakita T, Aizaki H.
  • Journal Title: PLoS One. Volume: 18
  • Peer Reviewed
• [Journal Article] Neutralizing antibodies induced by cell culture-derived hepatitis C virus protect against infection in mice. (2013)
  • Author(s): Akazawa D, Moriyama M, Yokokawa H, Omi N, Watanabe N, Date T, Morikawa K, Aizaki H, Ishii K, Kato T, Mochizuki H, Nakamura N, Wakita T.
  • Journal Title: Gastroenterology. Volume: 145 Pages: 447-455
  • Peer Reviewed
• [Journal Article] Hepatitis C virus translation preferentially depends on active RNA replication. (2012)
  • Author(s): Liu HM, Aizaki H, Machida K, Ou JH, Lai MM.
  • Journal Title: PLoS One. Volume: ７
  • Peer Reviewed
• [Journal Article] Trans-complemented hepatitis C virus particles as a versatile tool for study of virus assembly and infection. (2012)
  • Author(s): Suzuki R, Saito K, Kato T, Shirakura M, Akazawa D, Ishii K, Aizaki H, Kanegae Y, Matsuura Y, Saito I, Wakita T, Suzuki T.
  • Journal Title: Virology. Volume: 10 Pages: 29-38
  • Peer Reviewed
• [Journal Article] Japanese reference panel of blood specimens for evaluation of hepatitis C virus RNA and core antigen quantitative assays. (2012)
  • Author(s): Murayama A, Sugiyama N, Watashi K, Masaki T, Suzuki R, Aizaki H, Mizuochi T, Wakita T, Kato T.
  • Journal Title: J Clin Microbiol. Volume: 50 Pages: 1943-9
  • Peer Reviewed
• [Journal Article] Visualization and Measurement of ATP Levels in Living Cells Replicating Hepatitis C Virus Genome RNA. (2012)
  • Author(s): Ando T, Imamura H, Suzuki R, Aizaki H, Watanabe T, Wakita T, Suzuki T.
  • Journal Title: PLOS Pathogen Volume: 8
  • Peer Reviewed
• [Presentation] Prolactin regulatory element binding protein and Surfeit 4 are involved in hepatitis C virus replication compartment by interacting with NS4B. (2016)
  • Author(s): Kong L, Fujimoto A, Nakamura M, Aoyagi H, Matsuda M, Watashi K, Suzuki R, Arita M, Yamagoe S, Dohmae N, Suzuki T, Sakamaki Y, Ichinose S, Suzuki T, Wakita T, Aizaki H.
  • Organizer: Asian Pacific Association for the Study of the Liver
  • Place of Presentation: 東京
  • Year and Date: 2016-02-20
  • Int'l Joint Research
• [Presentation] 肝炎ウイルス検査陽性者アンケート調査の受診勧奨効果 (2015)
  • Author(s): 中野卓二、橋本千樹、川部直人、村尾道人、嶋崎宏明、菅敏樹、中岡和徳、高川友花、大城昌史、高村知希、野村小百合、吉岡健太郎、中田佳穂里、青山政美、片岡博喜、相崎英樹、是永匡紹.
  • Organizer: 第41回日本肝臓学会西部会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-12-03
• [Presentation] Development of a novel vaccine platform based on Japanese encephalitis viruses. (2015)
  • Author(s): Suzuki R, Saga R, Fujimoto A, Watanabe N, Matsuda M, Hasegawa M, Watashi K, Aizaki H, Nakamura N, Konishi E, Kato T, Tajima S, Takasaki T, Takeyama H, Wakita T.
  • Organizer: 日本分子生物学会第38回年会
  • Place of Presentation: 神戸
  • Year and Date: 2015-12-01
• [Presentation] Surfeit 4 is involved in HCV replication by interacting with NS4B. (2015)
  • Author(s): Lingbao K, Aoyagi H, Matsuda M, Fujimoto A, Watashi K, Suzuki R, Yamagoe S, Dohmae N, Sakamaki Y, Ichinose S, Suzuki T, Wakita T, Aizaki H.
  • Organizer: 日本ウイルス学会第63回学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2015-11-22
• [Presentation] Transfer hepatitis C virus between human liver cells and hepatic stellate cells. (2015)
  • Author(s): Aizaki H.
  • Organizer: The 2015 Italy-Japan Liver Workshop
  • Place of Presentation: Italy
  • Year and Date: 2015-10-26
  • Int'l Joint Research
• [Presentation] A new fungi-derived vanitaracin A specifically inhibits the entry of hepatitis B and D viruses through interacting with NTCP. (2015)
  • Author(s): Kaneko M, Watashi K, Kamisuki S, Matsunaga H, Iwamoto M, Kawai H, Ohashi H, Tsukuda S, Shimura S, Suzuki R, Aizaki H, Sugiyama M, Sam-Yong P, Ohtani N, Sugawara F, Tanaka Y, Mizokami M, Wakita T.
  • Organizer: 日本ウイルス学会第63回学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2015-10-22
• [Presentation] Transfer Hepatitis C virus from human liver cells to hepatic stellate cells. (2015)
  • Author(s): Zaitsu T, Aoyagi H, Fujimoto A, Matsuda M, Watanabe N, Watashi K, Suzuki R, Fukuhara T, Matsuura Y, Sakamaki Y, Ichinose S, Wake K, Suzuki T, Iijima H, Matsuura T, Tamura K, Wakita T, Aizaki H.
  • Organizer: 日本ウイルス学会第63回学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2015-10-22
• [Presentation] Multimerization of hepatitis B virus core protein regulated by microtubules. (2015)
  • Author(s): Iwamoto M, Watashi K, Sugiyama M, Suzuki R, Aizaki H, Tanaka Y, Mizokami M, Ohtani N, Koiwai O, Wakita T.
  • Organizer: 日本ウイルス学会第63回学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2015-10-22
• [Presentation] Identification of a flavonoid derivative that directly acts on hepatitis B virus surface protein and inhibits viral entry. (2015)
  • Author(s): Tsukuda S, Watashi K, Hamada Y, Isogawa M, Iwamoto M, Suzuki R, Aizaki H, Kojima S, Sugiyama M, Saito A, Tanaka Y, Mizokami M, Wakita T.
  • Organizer: 日本ウイルス学会第63回学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2015-10-22
• [Presentation] Bivalent vaccine platform based on Japanese encephalitis virus (JEV) elicit neutralizing antibodies against JEV and Hepatitis C virus. (2015)
  • Author(s): Saga R, Fujimoto A, Watanabe N, Matsuda M, Hasegawa M, Watashi K, Aizaki H, Nakamura N, Konishi E, Kato T, Tajima S, Takasaki T, Takeyama H, Wakita T, Suzuki R.
  • Organizer: 日本ウイルス学会第63回学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2015-10-22
• [Presentation] Flutamide-mediated Disruption of Lipid Droplets Impairs the Host Permissiveness to Hepatitis C virus Production. (2015)
  • Author(s): Ohashi H, Watashi K, Nakajima S, Sulyi K, Suzuki R, Aizaki H, Fukasawa M, Kamisuki S, Sugawara F, Ohtani N, Wakita T.
  • Organizer: 日本ウイルス学会第63回学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2015-10-22
• [Presentation] Japanese encephalitis virus (JEV)-subviral particles harboring HCV neutralization epitopes elicit neutralizing antibodies against JEV and HCV. (2015)
  • Author(s): Saga R, Fujimoto A, Watanabe N, Matsuda M, Hasegawa M, Watashi K, Aizaki H, Nakamura N, Konishi E, Kato T, Takeyama H, Wakita T, Suzuki R.
  • Organizer: International Symposium on Hepatitis C Virus and Related Viruses.
  • Place of Presentation: Strasbourg, France
  • Year and Date: 2015-10-09
  • Int'l Joint Research
• [Presentation] Prolactin regulatory element binding protein promotes the formation of HCV membranes replication compartment by interacting with NS4B. (2015)
  • Author(s): Kong L, Fujimoto A, Aoyagi H, Matsuda M, Watashi K, Suzuki R, Yamagoe S, Dohmae N, Suzuki T, Suzuki T, Wakita T, Aizaki H.
  • Organizer: International Symposium on Hepatitis C Virus and Related Viruses.
  • Place of Presentation: Strasbourg, France
  • Year and Date: 2015-10-09
  • Int'l Joint Research
• [Presentation] Identification of NTCP-targeting small molecules that inhibit HBV entry by cell-based and in vitro technologies. (2015)
  • Author(s): Watashi K, Tsukuda S, Shimura S, Kaneko M, Sluder A, Peel M, Kamisuki S, Matsunaga S, Morishita R, Futamura Y, Kondoh Y, Suzuki R, Aizaki H, Sugiyama M, Borroto-Esoda K, Ryo A, Sugawara F, Osada H, Tanaka Y, Mizokami M, Wakita T.
  • Organizer: International Meeting, Molecular Biology of Hepatitis B Viruses.
  • Place of Presentation: Dolce Bad Nauheim, Germany
  • Year and Date: 2015-10-04
  • Int'l Joint Research
• [Presentation] Cilnidipine inhibits the early phase of HBV infection in a NTCP independent mechanism. (2015)
  • Author(s): Tsukuda S, Watashi K, Iwamoto M, Suzuki R, Aizaki H, Tanaka Y, Wakita T.
  • Organizer: International Meeting, Molecular Biology of Hepatitis B Viruses.
  • Place of Presentation: Dolce Bad Nauheim, Germany
  • Year and Date: 2015-10-04
  • Int'l Joint Research
• [Presentation] Identification of a new tricyclic polyketide, vanitaracin A, which inhibits the entry of HBV, HDV, and nucleoside analog-resistant HBV through targeting NTCP. (2015)
  • Author(s): Kaneko M, Watashi K, Kamisuki S, Mtsunaga H, Iwamoto M, Kawai F, Ohashi H, Tsukuda S, Shimura S, Suzuki R, Aizaki H, Sugiyama M, Sam-Yong P, Ohtani N, Sugawara F, Tanaka Y, Mizokami M, Sureau C, Wakita T.
  • Organizer: International Meeting, Molecular Biology of Hepatitis B Viruses.
  • Place of Presentation: Dolce Bad Nauheim, Germany
  • Year and Date: 2015-10-04
  • Int'l Joint Research
• [Presentation] B型肝炎ウイルスに対する直接標的薬proanthocyanidinおよび宿主標的薬vanitalacinの感染阻害効果および作用機序の解析. (2015)
  • Author(s): 渡士幸一、九十田千子、金子学、松永大輝、紙透伸治、齊藤安貴子、鈴木亮介、相崎英樹、杉山真也、溝上雅史、菅原二三男、田中靖人、脇田隆字.
  • Organizer: 第25回抗ウイルス療法学会総会、
  • Place of Presentation: 東京
  • Year and Date: 2015-05-22
• [Presentation] Neoechinulin Bのliver X receptor転写阻害効果の同定およびそれによるC型肝炎ウイルス複製制御機構の解析. (2015)
  • Author(s): 渡士幸一、中嶋翔、紙透伸治、Jesus Izaguirre-Carbonell、Andrew Tae-Jun Kwon、鈴木治和、九十田千子、岡田麻衣子、鈴木亮介、相崎英樹、菅原二三男、脇田隆字.
  • Organizer: 第25回抗ウイルス療法学会総会
  • Place of Presentation: 東京
  • Year and Date: 2015-05-22
• [Presentation] 新規真菌二次代謝産物 SF177 の B 型肝炎ウイルス感染阻害活性および NTCP トランスポーター阻害活性の同定. (2015)
  • Author(s): 金子学, 渡士幸一，紙透伸治, 岩本将士，河合文啓, 鈴木亮介，相崎英樹，朴三用, 菅原二三男, 脇田隆字.
  • Organizer: 第25回抗ウイルス療法学会総会
  • Place of Presentation: 東京
  • Year and Date: 2015-05-22
• [Presentation] HCV複製複合体を含む膜小胞の形成メカニズムの解析. (2015)
  • Author(s): 相崎英樹、脇田隆字.
  • Organizer: 第51回日本肝臓学会総会
  • Place of Presentation: 熊本
  • Year and Date: 2015-05-21
• [Presentation] Retinoic acid receptor plays an important role in mediating hepatitis B virus infection through regulation of NTCP expression. (2014)
  • Author(s): Tsukuda S, Watashi K, Iwamoto M, Suzuki R, Aizaki H, Kojima S, Sugiyama M, Tanaka Y, Mizokami M, Wakita T.
  • Organizer: The 11th JSH Single Topic Conference
  • Place of Presentation: 広島
  • Year and Date: 2014-11-20 – 2014-11-21
• [Presentation] E1ペプチドによるHCV感染阻害機構の解析 (2014)
  • Author(s): 渡邉則幸、伊達朋子、河野環、溝上雅史 、相崎英樹、脇田隆字
  • Organizer: 第62回日本ウイルス学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2014-11-10 – 2014-11-12
• [Presentation] Aryl hydrocarbon receptor による脂肪滴形成及び C 型肝炎ウイルス粒子構築の制御 (2014)
  • Author(s): 大橋啓史、渡士幸一、中嶋翔、金ソルイ、鈴木亮介、相崎英樹、紙透伸治、菅原二三男、脇田隆字
  • Organizer: 第62回日本ウイルス学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2014-11-10 – 2014-11-12
• [Presentation] Prolactin regulatory element binding protein is involved in hepatitis C virus replication by interacting with NS4B. (2014)
  • Author(s): Lingbao Kong、青柳春代、松田麻未、藤本陽、渡士幸一、鈴木亮介、山越智、堂前直、鈴木健裕、鈴木哲朗、脇田隆字、相崎英樹
  • Organizer: 第62回日本ウイルス学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2014-11-10 – 2014-11-12
• [Presentation] 天然有機化合物 Neoechinulin B を利用した liver X receptor によるC 型肝炎ウイルス産生制御機構の解析 (2014)
  • Author(s): 中嶋翔、渡士幸一、紙透伸治、竹本健二、Jesus Izaguirre-Carbonell、鈴木亮介、相崎英樹、菅原二三男、脇田隆字
  • Organizer: 第62回日本ウイルス学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2014-11-10 – 2014-11-12
• [Presentation] 効率的な B 型肝炎ウイルス（HBV）複製評価系を用いた微小管依存的な HBV 複製機構の解析 (2014)
  • Author(s): 岩本将士、渡士幸一、杉山真也、鈴木亮介、相崎英樹、田中靖人、溝上雅史、大谷直子、小祝修、脇田隆字
  • Organizer: 第62回日本ウイルス学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2014-11-10 – 2014-11-12
• [Presentation] レチノイド阻害剤は NTCP 発現修飾を介して宿主細胞の B 型肝炎ウイルス感染感受性を消失させる (2014)
  • Author(s): 九十田千子、渡士幸一、岩本将士、鈴木亮介、相崎英樹、小嶋聡一、杉山 真也、田中靖人、溝上雅史、脇田隆字
  • Organizer: 第62回日本ウイルス学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2014-11-10 – 2014-11-12
• [Presentation] 遺伝子組換え酵母由来 B 型肝炎ウイルス様粒子の細胞表面への結合に関与する宿主因子の解析 (2014)
  • Author(s): 松田麻未、鈴木亮介、嵯峨涼平、藤本陽、渡士幸一、相崎英樹、森石恆司、岡本 徹、松浦善治、黒田俊一、脇田隆字
  • Organizer: 第62回日本ウイルス学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2014-11-10 – 2014-11-12
• [Presentation] B 型肝炎ウイルス（HBV）large S タンパク質と NTCP の相互作用阻害による抗 HBV 戦略 (2014)
  • Author(s): 渡士幸一、Sluder Ann、松永智子、梁明秀、森下了、岩本将士、九十田千子、鈴木亮介、相崎英樹、Borroto-Esoda Katyna、田中靖人、楠原洋之、杉山真也、溝上雅史、脇田隆字
  • Organizer: 第62回日本ウイルス学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2014-11-10 – 2014-11-12
• [Presentation] 日本脳炎ウイルスおよび C 型肝炎ウイルス 2 価ワクチン抗原の発現と中和抗体の誘導 (2014)
  • Author(s): 嵯峨涼平、藤本陽、渡邉則幸、松田麻未、長谷川慎、渡士幸一、相崎英樹、中村紀子、小西英二、加藤孝宣、田島茂、高崎智彦、竹山春子、脇田隆字、鈴木亮介
  • Organizer: 第62回日本ウイルス学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2014-11-10 – 2014-11-12
• [Presentation] Regulation of viral lifecycle in hepatitis C virus infection. (2014)
  • Author(s): Wakita T, Kong L, Aizaki H. Regulation of viral lifecycle in hepatitis C virus infection.
  • Organizer: Dynamic interplay between viruses and their hosts
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2014-11-08 – 2014-11-09
• [Presentation] Japanese encephalitis virus-subviral particles harboring HCV neutralization epitopes induce neutralizing antibodies against HCV. (2014)
  • Author(s): Saga R, Fujimoto A, Watanabe N, Matsuda M, Suzuki R, Hasegawa M, Watashi K, Aizaki H, Nakamura N, Konishi E, Kato T, Takeyama H, Wakita T.
  • Organizer: 21st International Symposium on Hepatitis C Virus and Related Viruses
  • Place of Presentation: Banff (Canada)
  • Year and Date: 2014-09-07 – 2014-09-11
• [Presentation] Single domain intrabodies against HCV core inhibit viral propagation and core-induced NF-kB activation. (2014)
  • Author(s): Suzuki R, Saito K, Matsuda M, Sato M, Kanegae Y, Watashi K, Aizaki H, Chiba J, Saito I, Wakita T, Suzuki T.
  • Organizer: 21st International Symposium on Hepatitis C Virus and Related Viruses
  • Place of Presentation: Banff (Canada)
  • Year and Date: 2014-09-07 – 2014-09-11
• [Presentation] Identification of an important envelope region by competitive inhibition experiment with envelope peptides. (2014)
  • Author(s): Watanabe N, Date T, Kono T, Aizaki H, Wakita T.
  • Organizer: 21st International Symposium on Hepatitis C Virus and Related Viruses
  • Place of Presentation: Banff (Canada)
  • Year and Date: 2014-09-07 – 2014-09-11
• [Presentation] Maintenance of HCV infectivity by down-regulating hepatic lipase expression. (2014)
  • Author(s): Fujimoto A, Aizaki H, Matsuda M, Watanabe N, Watashi K, Suzuki R, Suzuki T, Wakita T.
  • Organizer: 21st International Symposium on Hepatitis C Virus and Related Viruses
  • Place of Presentation: Banff (Canada)
  • Year and Date: 2014-09-07 – 2014-09-11
• [Presentation] NS5A-associated membrane protein, embryonic lethal, abnormal vision, drosophila-like 1, regulates hepatitis C virus RNA synthesis and translation. (2014)
  • Author(s): Goto K, Fujimoto A, Watashi K, Suzuki R, Yamagoe S, Moriya K, Yotsuyanagi H, Koike K, Suzuki T, Wakita T, Aizaki H.
  • Organizer: 21st International Symposium on Hepatitis C Virus and Related Viruses
  • Place of Presentation: Banff (Canada)
  • Year and Date: 2014-09-07 – 2014-09-11
• [Presentation] Flutamide Inhibits Hepatitis C Virus Assembly through Disrupting Lipid Droplets. (2014)
  • Author(s): Ohashi H, Watashi K, Nakajima S, Kim S, Suzuki R, Aizaki H, Kamisuki S, Sugawara F, Wakita T.
  • Organizer: 21st International Symposium on Hepatitis C Virus and Related Viruses
  • Place of Presentation: Banff (Canada)
  • Year and Date: 2014-09-07 – 2014-09-11
• [Presentation] Regulation of hepatitis C virus replication by liver X receptor is disrupted by a fungi-derived neoechinulin B. (2014)
  • Author(s): Nakajima S, Watashi K, Kamisuki S, Takemoto K, Suzuki R, Aizaki H, Sugawara F, Wakita T.
  • Organizer: 21st International Symposium on Hepatitis C Virus and Related Viruses
  • Place of Presentation: Banff (Canada)
  • Year and Date: 2014-09-07 – 2014-09-11
• [Presentation] Construction of novel infectious genotype 2b culture system. (2014)
  • Author(s): Hmwe SS, Suda G, Sakamoto N, Imamura M, Hiraga N, Chayama K, Aizaki H, Wakita T.
  • Organizer: 21st International Symposium on Hepatitis C Virus and Related Viruses
  • Place of Presentation: Banff (Canada)
  • Year and Date: 2014-09-07 – 2014-09-11
• [Presentation] Characterization of a culture system reproducing the NTCP-mediated HBV entry and ITS application to drug development. 2014 International Meeting on Molecular Biology of Hepatitis B Viruses (2014)
  • Author(s): Watashi K, Iwamoto M, Sluder A, Matsunaga S, Ryo A, Morishita R, Kwon ATJ, Suzuki H, Tsukuda S, Suzuki R, Aizaki H, Borroto-Esoda K, Sugiyama M, Tanaka Y, Mizokamai M, Wakita T.
  • Organizer: International Meeting on the Molecular Biology of Hepatitis B Viruses
  • Place of Presentation: Los Angeles (USA)
  • Year and Date: 2014-09-03 – 2014-09-06
• [Presentation] Microtubule-dependent hepatitis B virus (HBV) replication revealed by chemical screening on an efficient HBV-replicating cell line. (2014)
  • Author(s): Iwamoto M, Watashi K, Sugiyama M, Suzuki R, Aizaki H, Tanaka Y, Mizokami M, Ohtani N, Koiwai O, Wakita T.
  • Organizer: International Meeting on the Molecular Biology of Hepatitis B Viruses
  • Place of Presentation: Los Angeles (USA)
  • Year and Date: 2014-09-03 – 2014-09-06
• [Presentation] Retinoid inhibitors abolish the host permissiveness to HBV infection by modulating NTCP expression. (2014)
  • Author(s): Tsukuda S, Watashi K, Iwamoto M, Suzuki R, Aizaki H, Kojima S, Sugiyama M, Tanaka Y, Mizokami M, Wakita T.
  • Organizer: International Meeting on the Molecular Biology of Hepatitis B Viruses
  • Place of Presentation: Los Angeles (USA)
  • Year and Date: 2014-09-03 – 2014-09-06
• [Presentation] ヒトNTCP安定発現によるB型肝炎ウイルス(HBV)感染許容性の獲得とそれを用いたHBV侵入機構の解析 (2014)
  • Author(s): 岩本将士、渡士幸一、九十田千子、Hussein Aly、藤本陽、鈴木亮介、相崎英樹、脇田隆字、深澤征義、小祝修、楠原洋之
  • Organizer: 第22回肝病態生理研究会
  • Place of Presentation: 東京
  • Year and Date: 2014-05-31
• [Presentation] 培養系を用いた抗B型肝炎ウイルス化合物の同定と作用機序解析 (2014)
  • Author(s): 渡士幸一、相崎英樹、脇田隆字
  • Organizer: 第50回日本肝臓学会総会
  • Place of Presentation: 東京
  • Year and Date: 2014-05-29 – 2014-05-30
• [Presentation] グリチルリチンによる抗C型肝炎ウイルス作用 - phospholipase A2およびAutophagyによるHCV分泌過程の制御 (2014)
  • Author(s): 青柳東代、相崎英樹、松本喜弘、鈴木亮介、渡士幸一、市野瀬志津子、松浦知和、鈴木哲朗、和氣健二郎、脇田隆字
  • Organizer: 第50回日本肝臓学会総会
  • Place of Presentation: 東京
  • Year and Date: 2014-05-29 – 2014-05-30
• [Presentation] C型肝炎ウイルス生活環全体を標的とした新規作用を有する抗ウイルス剤の探索 (2014)
  • Author(s): 脇田隆字、相崎英樹、渡士幸一
  • Organizer: 第50回日本肝臓学会総会
  • Place of Presentation: 東京
  • Year and Date: 2014-05-29 – 2014-05-30
• [Presentation] B型肝炎ウイルス(HBV)Lタンパク質とNTCPの相互作用阻害による抗HBV戦略 (2014)
  • Author(s): 渡士幸一、Ann Sluder、松永智子、梁明秀、森下了、岩本将士、九十田千子、鈴木亮介、相崎英樹、Katyna Borroto-Esoda、田中靖人、楠原洋之、杉山真也、溝上雅史、脇田隆字
  • Organizer: 第24回抗ウイルス療法研究会総会
  • Place of Presentation: 富士吉田
  • Year and Date: 2014-05-07 – 2014-06-09
• [Presentation] グリチルリチンによる抗HCV作用 - phospholipase A2およびAutophagyによるC型肝炎ウイルス(HCV)分泌過程に与える影響 (2014)
  • Author(s): 青柳東代、相崎英樹、藤本陽、松本喜弘、松田麻未、Su Su Hmwe、渡邉則幸、渡士幸一、鈴木亮介、市野瀬志津子、松浦知和、鈴木哲朗、和氣健二郎、脇田隆字
  • Organizer: 第24回抗ウイルス療法研究会総会
  • Place of Presentation: 富士吉田
  • Year and Date: 2014-05-07 – 2014-05-09
• [Presentation] C型肝炎ウイルス粒子の構築を阻害するflutamideの作用機序の解析 (2014)
  • Author(s): 大橋啓史、渡士幸一、中嶋翔、金ソルイ、鈴木亮介、相崎英樹、紙透伸治、菅原二三男、脇田隆字
  • Organizer: 第24回抗ウイルス療法研究会総会
  • Place of Presentation: 富士吉田
  • Year and Date: 2014-05-07 – 2014-05-09
• [Presentation] HBV感染受容体NTCPの発現調節機構の解析およびこれを阻害する低分子化合物の抗HBV効果 (2014)
  • Author(s): 九十田千子、渡士幸一、岩本将士、鈴木亮介、相崎英樹、小嶋聡一、脇田隆字
  • Organizer: 第24回抗ウイルス療法研究会総会
  • Place of Presentation: 富士吉田
  • Year and Date: 2014-05-07 – 2014-05-09
• [Presentation] Mechanistic analysis on hepatitis B virus entry in an NTCP-overexpressing cell line. (2013)
  • Author(s): Iwamoto M, Watashi K, Tsukuda S, Aly HH, Suzuki R, Aizaki H, Koiwai H, Kusuhara H, Wakita T
  • Organizer: 2013 International Meeting on the Molecular Biology of Hepatitis B Viruses.
  • Place of Presentation: Shanghai, China.
• [Presentation] A Retinoid Derivative Inhibits Hepatitis B Virus Entry Mediated by NTCP. (2013)
  • Author(s): Tsukuda S, Watashi K, Iwamoto M, Suzuki R, Aizaki H, Kojima S, Wakita T.
  • Organizer: International Meeting on Molecular Biology of Hepatitis B Viruses.
  • Place of Presentation: Shanghai, China.
• [Presentation] Interleukin-1 and tumor necrosis factor-alpha trigger restriction of hepatitis B virus infection via a cytidine deaminase AID. (2013)
  • Author(s): Watashi K, Liang G, Iwamoto M, Marusawa H, Kitamura K, Muramatsu M, Suzuki R, Li J, Tong S, Tanaka Y, Murata K, Aizaki H, Wakita T.
  • Organizer: 2013 International Meeting on Molecular Biology of Hepatitis B viruses
  • Place of Presentation: Shanghai, China.
• [Presentation] Dynamics of the cellular metabolome during hepatitis C virus infection: Regulation of the lipoprotein metabolisms by hepatic lipase. (2013)
  • Author(s): Fujimoto A, Aizaki H, Matsuda M, Watanabe N, Watashi K, Suzuki R, Suzuki T, Miyamura T, Wakita T
  • Organizer: 20th International Symposium on Hepatitis C Virus and Related Viruses
  • Place of Presentation: Melbourne, Australia
• [Presentation] Identification of a natural product inhibiting the transcriptional activity of liver X receptor and reducing the production of infectious HCV (2013)
  • Author(s): Nakajima S, Watashi K, Kamisuki S, TakemotoK,SuzukiR,AizakiH,SugawaraF, Wakita T
  • Organizer: 20th International Symposium on Hepatitis C Virus and Related Viruses
  • Place of Presentation: Melbourne, Australia
• [Presentation] Analysis of bioactivity of fungal-derived natural products based on a virus infection system (2013)
  • Author(s): Nakajima S, Watashi K, Kamisuki S, TakemotoK,SuzukiR,AizakiH,SugawaraF,Wakita T
  • Organizer: The 2nd International Symposium on Chemical Biology of Natural Products: Target ID and Regulation of Bioactivity
  • Place of Presentation: Yokohama
• [Presentation] Production of single-round infectious chimeric flaviviruses with a DNA-based Japanese encephalitis virus replicon. (2013)
  • Author(s): Suzuki R, Konishi E, Ishikawa T, Matsuda M, Watashi K, Aizaki H, Takasaki T, WakitaT.
  • Organizer: Keystone Symposia, Positive Strand RNA Viruses
  • Place of Presentation: Boston, U.S.A.
• [Presentation] Dynamic metabolomics change in HCV-infected cells, (2013)
  • Author(s): Aizaki H
  • Organizer: The 2013 Italy- Japan Liver Workshop“Hepatitis, Steatosis and Hepatocellular Carcinoma: molecular basis and clinical links”
  • Place of Presentation: Italy
• [Presentation] Hepatitis C virus RNA replication in human stellate cells regulates gene expression of extracellular matrix-related molecules (2013)
  • Author(s): Aizaki H, Watanabe N, Aoyagi H, Hmwe SS, Watashi K, Suzuki R, Kojima S, Matsuura T, Wake K, Miyamura T, Suzuki T, Wakita T
  • Organizer: International Symposium on Cells of the Hepatic Sinusoid
  • Place of Presentation: Osaka
• [Presentation] HCV NS3 protease plus TNF-α promotes liver fibrosis via stimulating expression and activation of TGF-β type I receptor (2013)
  • Author(s): Sakata K, Hara M, Terada T, Watanabe N, Yaguchi S, Matsumoto M, Shirouzu M, Yokoyama S, Miyazawa K, Aizaki H, Suzuki T, Wakita T,Kojima S
  • Organizer: 第20回肝細胞研究会
  • Place of Presentation: Osaka
• [Presentation] Antiviral activity of glycyrrhizin against hepatitis C virus in vitro (2013)
  • Author(s): Aoyagi H, Aizaki H, Matsumoto Y, Matsuda M, Hmwe SS, Watanabe N, Watashi K, SuzukiR,IchinoseS,MatsuuraT,SuzukiT, -79- Wake K, Miyamura T, Wakita T.
  • Organizer: The 12th Awaji international forum on infection and immunity
  • Place of Presentation: Awaji
• [Presentation] Comprehensive and comparative proteomics reveals alterations of metabolomics between monolayer and three- dimensional cell cultures. (2013)
  • Author(s): agamori S, Aizaki H, Matsumoto Y, Isozumi N, Wiriyasermkul P, Matsuura T, Kanai Y
  • Organizer: 12th Human Proteome Organization World Congress 2013.
  • Place of Presentation: Yokohama
• [Presentation] Regulation of Hepatitis C virus (HCV) release by phospholipase A2 and autophagy -Antiviral Activity of Glycyrrhizin against HCV (2013)
  • Author(s): Aoyagi H, Aizaki H, Matsumoto Y, Matsuda M, Hmwe SS, Watanabe N, Watashi K, Suzuki R, Ichinose S, Matsuura T, Suzuki T, Wake K, Miyamura T, Wakita T.
  • Organizer: 日本 分子生物学会第36回年会
  • Place of Presentation: 神戸
• [Presentation] プラスミドトランスフェクションに よるトランスパッケージング型1回感染性フラ ビウイルス産生系の確立. (2013)
  • Author(s): 鈴木亮介、石川知弘、小西英二、嵯峨涼平、 松田麻未、渡士幸一、相崎英樹、高崎智彦、脇 田隆字
  • Organizer: 日本分子生物学会 第36回年会
  • Place of Presentation: 神戸
• [Presentation] 細胞内発現抗体 (イントラボディ)によるC型肝炎ウイルスの 増殖抑制. (2013)
  • Author(s): 松田麻未、斎藤憲司、鈴木亮介、佐藤充、 鐘ヶ江裕美、渡士幸一、相崎英樹、千葉丈、斎 藤泉、脇田隆字、鈴木哲朗.
  • Organizer: 日本ウイルス学会第61回学術集会
  • Place of Presentation: 神戸
• [Presentation] Phospholipase A2およびAutophagyによるC型肝 炎ウイルス(HCV)分泌過程の制御 ― グリチルリ チンによる抗HCV作用― (2013)
  • Author(s): 青柳東代, 相崎英樹, 藤本陽, 松本喜弘, 松田麻未, Su Su Hmwe,渡邉則幸, 渡士幸一, 鈴木亮介, 市野瀬志津子, 松浦知和, 鈴木哲 朗, 和氣健二郎, 宮村達男, 脇田隆字.
  • Organizer: 日本ウイルス学会第 61回学術集会
  • Place of Presentation: 神戸
• [Presentation] C型肝炎ウイルス感染による宿主細胞の 脂質代謝変化とHepatic Lipase発現制御 (2013)
  • Author(s): 藤本陽, 相崎英樹, 松田麻未, 渡邉則幸, 渡士幸一, 鈴木亮介, 鈴木哲朗, 宮村達男, 脇 田隆字
  • Organizer: 日本 ウイルス学会第61回学術集会
  • Place of Presentation: 神戸
• [Presentation] C型肝炎ウイルス分泌過程はphospholipase Dが 関わる膜輸送により制御される (2013)
  • Author(s): 内田奈々子、渡士幸一、中嶋 翔、岩本将 士、鈴木亮介、相崎英樹、千葉 丈、脇田隆字
  • Organizer: 日本ウイルス 学会第61回学術集会
  • Place of Presentation: 神戸
• [Presentation] B型肝炎 ウイルス侵入阻害剤の同定およびそのNTCPを介 した感染阻害機構の解明 (2013)
  • Author(s): 九十田千子、渡士幸一、岩本将士、鈴木亮 介、相崎英樹、小嶋聡一、脇田隆字
  • Organizer: 日本 ウイルス学会第61回学術集会
  • Place of Presentation: 神戸
• [Presentation] ヒトNTCP安定発 現細胞株におけるB型肝炎ウイルス侵入機構の 解析 (2013)
  • Author(s): 岩本将士、渡士幸一、九十田千子、 Hussein Hassan Aly、鈴木亮介、相崎英樹、小 祝 修、楠原洋之、脇田隆字
  • Organizer: 日本 ウイルス学会第61回学術集会
  • Place of Presentation: 神戸
• [Presentation] エンベロープペプチドを用いたHCV感染に重 要なアミノ酸領域の探索 (2013)
  • Author(s): 渡邉則幸, 伊達朋子、相崎英樹、脇田隆字
  • Organizer: 日本 ウイルス学会第61回学術集会
  • Place of Presentation: 神戸
• [Presentation] C型肝炎 ウイルスNS5A結合タンパク質ELAVL1のウイルス 複製・翻訳スイッチング機構の解析 (2013)
  • Author(s): 後藤耕司、相崎英樹、渡邉則幸、渡士幸一、 鈴木亮介、山越智、四柳宏、森屋恭爾、小池和 彦、鈴木哲朗、宮村達男、脇田隆字
  • Organizer: 日本 ウイルス学会第61回学術集会
  • Place of Presentation: 神戸
• [Presentation] IL-1/TNFaによるシチジンデ アミナーゼAID誘導を介したB型肝炎ウイルス感 染排除機構 (2013)
  • Author(s): 渡士幸一、Guoxin Liang、岩本将士、丸澤 宏之、喜多村晃一、村松正道、鈴木亮介、相崎 英樹、脇田隆字
  • Organizer: 日本 ウイルス学会第61回学術集会
  • Place of Presentation: 神戸
• [Presentation] Liver X Receptor 転写 活性および感染性C型肝炎ウイルス粒 子産生を阻害する天然有機化合物の同 定 (2013)
  • Author(s): 中嶋翔、渡士幸一、紙透伸治、竹本 健二、鈴木亮介、相崎英樹、菅原二三 男、脇田隆字
  • Organizer: 日本 ウイルス学会第61回学術集会
  • Place of Presentation: 神戸
• [Presentation] 当院で経験した、HIV陽性者に おける急性C型肝炎の集団発生について (2013)
  • Author(s): 井戸田一朗、加藤康幸、青柳東代、相崎英 樹、脇田隆字
  • Organizer: 第27 回日本エイズ学会
  • Place of Presentation: 熊本
• [Presentation] Independent evolution of multi-dominant viral genome species observed in a single HCV carrier. (2012)
  • Author(s): Ando T, Aizaki H, Sugiyama M, Mizokami M, Kuroda M, Wakita T.
  • Organizer: International Meeting on Hepatitis C Virus and Related Viruses.
  • Place of Presentation: Italy
  • Invited
• [Presentation] Characterization of anti-HCV release inhibitors targeting phospholipase D. (2012)
  • Author(s): atashi K, Uchida N, Saeed M, Suzuki R, Aizaki H, Wakita T.
  • Organizer: 19th International Meeting on Hepatitis C Virus and Related Viruses.
  • Place of Presentation: Italy
  • Invited
• [Presentation] Antiviral activity of glycyrrhizin against Hepatitis C virus in vitro. (2012)
  • Author(s): Matsumoto Y, Watanabe N, Watashi K, Suzuki R, Matsuura T, Suzuki T, Miyaura T, Wake K, Wakita T, Aizaki H.
  • Organizer: 19th International Meeting on Hepatitis C Virus and Related Viruses.
  • Place of Presentation: Italy
  • Invited
• [Presentation] Neutralizing antibodiesninduced by cell cultute-derived Hepatitis C virus was effective both in vitro and in vivo. (2012)
  • Author(s): Akazawa D, Moriyama M, Yokokawa N, Watanabe N, Date T, Morikawa K, Aizaki H, Ishii K, Kato T, Nakamura N, Wakita T.
  • Organizer: 19th International Meeting on Hepatitis C Virus and Related Viruses.
  • Place of Presentation: Italy
  • Invited
• [Presentation] NS3 protease derived from genotype 1b Con1 attenuates viral replication. (2012)
  • Author(s): Kim S, Date T, Aizaki H, Watanabe H, Wakita T.
  • Organizer: 19th International Meeting on Hepatitis C Virus and Related Viruses.
  • Place of Presentation: Italy
  • Invited
• [Book] C型肝炎治療における新時代の幕開け、C型肝炎ウイルスの複製・増殖のメカニズム (2016)
  • Author(s): 相崎英樹、脇田隆字
  • Total Pages: 4
  • Publisher: 医薬ジャーナル社
• [Book] 肝炎ウイルス検査のすすめ；身近にひそむ危険を防ぐ (2016)
  • Author(s): 相崎英樹、脇田隆字
  • Total Pages: 2
  • Publisher: 国民生活センター
• [Book] HCV研究の最先端,HCV感染実験系における代謝変化. (2014)
  • Author(s): 相崎英樹,松田麻未,藤本陽,脇田隆字.
  • Total Pages: 4
  • Publisher: 日本メディカルセンター
• [Book] 医学のあゆみ (2013)
  • Author(s): 相崎英樹
  • Total Pages: 2
  • Publisher: 医歯薬出版株式会社
• [Book] 臨床とウイルス (2012)
  • Author(s): 田中純子、小山富子、相崎英樹.
  • Publisher: 日本臨床ウイルス学会
• [Book] 医学の歩み (2012)
  • Author(s): 相崎英樹
  • Publisher: 医学の歩み社
• [Book] Liver Forum in Kyoto第14回学術集会記録集 (2012)
  • Author(s): 相崎英樹
  • Publisher: メディカルトリビューン
• [Book] 細胞 (2012)
  • Author(s): 相崎英樹
  • Publisher: ニューサイエンス社
• [Remarks] 国立感染症研究所ウイルス第二部
  • URL: http://www.nih.go.jp/niid/ja/vir2-hv.html
• [Remarks] 国立感染症研究所ウイルス第二部
• [Remarks] 国立感染症研究所ウイルス第二部