• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

The prevention of pancreatic diseases targeting for the pancreatic stem/progenitor cell niche

Research Project

Project/Area Number 24591003
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Gastroenterology
Research InstitutionTohoku University

Principal Investigator

KIKUTA Kazuhiro  東北大学, 医学(系)研究科(研究院), 非常勤講師 (80420024)

Co-Investigator(Kenkyū-buntansha) MASAMUNE Atsushi  東北大学, 医学系研究科, 准教授 (90312579)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords急性膵炎 / 慢性膵炎 / 糖尿病 / 膵星細胞 / 膵線維化
Outline of Final Research Achievements

To clarify the role of pancreatic stellate cells for the progression of pancreatic endocrine and exocrine dysfunction, the role of kindlin-2, a key regulator for integrin signaling, in pancreatic stellate cells was studied. Pancreatic stellate cells expressed kindlin-2. The decreased expression of kindlin-2 inhibited the migration of pancreatic stellate cells. Kindlin-2 may have a role in the pancreatic microenvironment. The epidemiological association between pancreatic dysfunction and pancreatitis was also studied. Sixty five point seven percent and 45.7% of chronic pancreatitis patients who were diagnosed as definite chronic pancreatitis within a year showed pancreatic exocrine and endocrine dysfunction, respectively. Acute pancreatitis patients had higher morbidity of diabetes mellitus than normal population. Idiopathic or elder acute pancreatitis patients with diabetes mellitus had a higher mortality.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (43 results)

All 2014 2013 2012

All Journal Article (30 results) (of which Peer Reviewed: 22 results) Presentation (13 results)

  • [Journal Article] Sudden disappearance of the blood flow in a case of pancreatic acinar cell carcinoma2014

    • Author(s)
      Kanno A, Masamune A, Hamada S, Kikuta K, Kume K, Hirota M, Shima K, Okada T, Motoi F, Fujishima F, Ishida K, Unno M, Shimosegawa T
    • Journal Title

      Intern Med

      Volume: 53 Pages: 2589-2593

    • NAID

      130004713252

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bismuth classification is associated with the requirement for multiple biliary drainage in preoperative patients with malignant perihilar biliary stricture2014

    • Author(s)
      Miura S, Kanno A, Masamune A, Hamada S, Takikawa T, Nakano E, Yoshida N, Hongo S, Kikuta K, Kume K, Hirota M, Yoshida H, Katayose Y, Unno M, Shimosegawa T
    • Journal Title

      Surg Endosc

      Volume: in press Issue: 7 Pages: 1862-1870

    • DOI

      10.1007/s00464-014-3878-y

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The seventh nationwide epidemiological survey for chronic pancreatitis in Japan: clinical significance of smoking habit in Japanese patients2014

    • Author(s)
      Hirota M, Shimosegawa T, Masamune A, Kikuta K, Kume K, Hamada S, Kanno A, Kimura K, Tsuji I, Kuriyama S; Research Committee of Intractable Pancreatic Diseases
    • Journal Title

      Pancreatology

      Volume: 14 Issue: 6 Pages: 490-496

    • DOI

      10.1016/j.pan.2014.08.008

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The usefulness of endoscopic ultrasound-guided fine-needle aspiration for the diagnosis of pancreatic neuroendocrine tumors based on the World Health Organization classification2014

    • Author(s)
      Unno J, Kanno A, Masamune A, Kasajima A, Fujishima F, Ishida K, Hamada S, Kume K, Kikuta K, Hirota M, Motoi F, Unno M, Shimosegawa T
    • Journal Title

      Scand J Gastroenterol

      Volume: 49 Issue: 11 Pages: 1367-1374

    • DOI

      10.3109/00365521.2014.934909

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nationwide epidemiological survey of acute pancreatitis in Japan2014

    • Author(s)
      Hamada S, Masamune A, Kikuta K, Hirota M, Tsuji I, Shimosegawa T; Research Committee of Intractable Diseases of the pancreas
    • Journal Title

      Pancreas

      Volume: 43 Issue: 8 Pages: 1244-1248

    • DOI

      10.1097/mpa.0000000000000200

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 慢性膵炎に伴う線維化機構2014

    • Author(s)
      菊田和宏、正宗淳、下瀬川徹
    • Journal Title

      胆と膵

      Volume: 35 Pages: 1035-1039

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 我が国の急性膵炎の予後2014

    • Author(s)
      菊田和宏、正宗淳、濱田晋、下瀬川徹
    • Journal Title

      膵臓

      Volume: 29 Pages: 151-156

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 慢性膵炎の膵内外分泌機能と臨床像 - 全国調査から2014

    • Author(s)
      菊田和宏、正宗淳、下瀬川徹
    • Journal Title

      胆と膵

      Volume: 35 Pages: 343-347

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 膵星細胞と膵島細胞の相関2014

    • Author(s)
      菊田和宏、正宗淳、濱田晋、滝川哲也、中野絵里子、下瀬川徹、
    • Journal Title

      胆と膵

      Volume: 35 Pages: 339-342

    • Related Report
      2014 Annual Research Report 2013 Research-status Report
  • [Journal Article] 全国調査から見たアルコール性急性膵炎の疫学的特徴2014

    • Author(s)
      菊田和宏、正宗淳、粂潔、下瀬川徹
    • Journal Title

      アルコールと医学生物学

      Volume: 32

    • Related Report
      2013 Research-status Report
  • [Journal Article] 高齢者急性膵炎の臨床的特徴2014

    • Author(s)
      菊田和宏、正宗淳、下瀬川徹
    • Journal Title

      消化器内科

      Volume: 58 Pages: 95-101

    • Related Report
      2013 Research-status Report
  • [Journal Article] 全国調査からみた急性膵炎における耐糖能障害2014

    • Author(s)
      菊田和宏、正宗淳、下瀬川徹
    • Journal Title

      消化と吸収

      Volume: 36

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 慢性膵炎の膵内外分泌機能と臨床像-全国調査から2014

    • Author(s)
      菊田和宏、正宗淳、下瀬川徹
    • Journal Title

      胆と膵

      Volume: 35 Pages: 343-347

    • Related Report
      2013 Research-status Report
  • [Journal Article] 我が国の急性膵炎の予後:全国調査から2014

    • Author(s)
      菊田和宏、正宗淳、濱田晋、下瀬川徹
    • Journal Title

      膵臓

      Volume: 29

    • NAID

      130004496059

    • Related Report
      2013 Research-status Report
  • [Journal Article] CONUTによる急性膵炎の栄養評価2013

    • Author(s)
      菊田和宏、正宗淳、下瀬川徹
    • Journal Title

      消化と吸収

      Volume: 35 Pages: 193-196

    • NAID

      10031169262

    • Related Report
      2013 Research-status Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Pancreatic stellate cells reduce insulin expression and induce apoptosis in pancreaticβ-cells2013

    • Author(s)
      Kikuta K, Masamune A, Hamada S, Takikawa T, Nakano E, Shimosegawa T.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 433 Issue: 3 Pages: 292-7

    • DOI

      10.1016/j.bbrc.2013.02.095

    • Related Report
      2013 Research-status Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] The angiotensin II type I receptor blocker olmesartan inhibits the growth of pancreatic cancer by targeting stellate cell activities in mice2013

    • Author(s)
      Masamune A, Hamada S, Kikuta K, Takikawa T, Miura S, Nakano E, Shimosegawa T.
    • Journal Title

      Scand J Gastroenterol

      Volume: 48 Issue: 5 Pages: 602-609

    • DOI

      10.3109/00365521.2013.777776

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] miR-197 induces epithelialmesenchymal transition in pancreatic cancer cells by targeting p120 catenin. J Cell Physiol2013

    • Author(s)
      Hamada S, et al
    • Journal Title

      J Cell Physiol

      Volume: 228(6) Issue: 6 Pages: 1255-63

    • DOI

      10.1002/jcp.24280

    • Related Report
      2013 Research-status Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Pancreati duct drainage using EUS-guided rendezvous technique for stenotic pancreaticojejunostomy2013

    • Author(s)
      Takikawa T, Kanno A, Masamune A, Hamada S, Nakano E, Miura S, Ariga H, Unno J, Kume K, Kikuta K, Hirota M, Yoshida H, Katayose Y, Unno M, Shimosegawa T
    • Journal Title

      World J Gastroenterol

      Volume: 19 Issue: 31 Pages: 5182-5186

    • DOI

      10.3748/wjg.v19.i31.5182

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] The angiotensin II type I receptor blocker olmesartan inhibits the growth of pancreatic cancer by targeting stellate cell activities in mice.2013

    • Author(s)
      Masamune A, Hamada S, Kikuta K, Takikawa T, Miura S, Nakano E, Shimosegawa T.
    • Journal Title

      Scand J Gastroenterol

      Volume: in press

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Connexins Regulate Cell Functions in Pancreatic Stellate Cells.2013

    • Author(s)
      Masamune A, Suzuki N, Kikuta K, Ariga H, Hayashi S, Takikawa T, Kume K, Hamada S, Hirota M, Kanno A, Egawa S, Unno M, Shimosegawa T.
    • Journal Title

      Pancreas

      Volume: in press

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] [Case report; Multiple gastrointestinal stromal tumors associated with neurofibromatosis type I preoperatively diagnosed by endoscopic ultrasound-guided fine-needle aspiration: report of a case and review of literature].2012

    • Author(s)
      Miura S, Kume K, Hamada S, Kanno A, Unno J, Kikuta K, Hirota M, Masamune A, Shimosegawa T.
    • Journal Title

      Nihon Naika Gakkai Zasshi

      Volume: 101 Pages: 3510-3512

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Distinct clinical features of two patients that progressed from the early phase of chronic pancreatitis to the advanced phase.2012

    • Author(s)
      Hirota M, Shimosegawa T, Kanno A, Kikuta K, Kume K, Hamada S, Unno J, Masamune A.
    • Journal Title

      Tohoku J Exp Med

      Volume: 228 Pages: 173-180

    • NAID

      10031127345

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Diagnosis of autoimmune pancreatitis by EUS-FNA by using a 22-gauge needle based on the International Consensus Diagnostic Criteria.2012

    • Author(s)
      Kanno A, Ishida K, Hamada S, Fujishima F, Unno J, Kume K, Kikuta K, Hirota M, Masamune A, Satoh K, Notohara K, Shimosegawa T.
    • Journal Title

      Gastrointest Endosc

      Volume: 76 Issue: 3 Pages: 594-602

    • DOI

      10.1016/j.gie.2012.05.014

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Early detection of low enhanced pancreatic parenchyma by contrast-enhanced computed tomography predicts poor prognosis of patients with acute pancreatitis.2012

    • Author(s)
      Hirota M, Satoh K, Kikuta K, Masamune A, Kume K, Hamada S, Satoh A, Kanno A, Unno J, Ito H, Ariga H, Shimosegawa T.
    • Journal Title

      Pancreas

      Volume: 41 Issue: 7 Pages: 1099-1104

    • DOI

      10.1097/mpa.0b013e318249a904

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Kanno A, Masamune A, Hirota M, Kikuta K, Shimosegawa T.2012

    • Author(s)
      Successful treatment of benign biliary stricture by a covered self-expandable metallic stent in a patient with chronic pancreatitis.
    • Journal Title

      Dig Endosc

      Volume: 24 Suppl 1 Issue: s1 Pages: 43-48

    • DOI

      10.1111/j.1443-1661.2012.01263.x

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Do genetic variants in the SPINK1 gene affect the level of serum PSTI?2012

    • Author(s)
      Kume K, Masamune A, Ariga H, Hayashi S, Takikawa T, Miura S, Suzuki N, Kikuta K, Hamada S, Hirota M, Kanno A, Shimosegawa T.
    • Journal Title

      J Gastroenterol

      Volume: 47 Issue: 11 Pages: 1267-1274

    • DOI

      10.1007/s00535-012-0590-3

    • NAID

      10031126959

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Pancreatic stellate cells enhance stem cell-like phenotypes in pancreatic cancer cells2012

    • Author(s)
      Hamada S, Masamune A, Takikawa T, Suzuki N, Kikuta K, Hirota M, Hamada H, Kobune M, Satoh K, Shimosegawa T
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 421(2) Issue: 2 Pages: 349-354

    • DOI

      10.1016/j.bbrc.2012.04.014

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Research Committee on Intractable Diseases of Pancreas. Nationwide epidemiological survey of autoimmune pancreatitis in Japan2012

    • Author(s)
      Kanno A, Nishimori I, Masamune A, Kikuta K, Hirota M, Kuriyama S, Tsuji I, Shimosegawa T
    • Journal Title

      Pancreas

      Volume: 41 Issue: 6 Pages: 835-9

    • DOI

      10.1097/mpa.0b013e3182480c99

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 急性膵炎の成因と疫学2012

    • Author(s)
      菊田和宏、正宗淳、下瀬川徹
    • Journal Title

      消化器外科

      Volume: 35 Pages: 1725-1730

    • Related Report
      2012 Research-status Report
  • [Presentation] The impact of diabetes mellitus on clinical outcome of acute pancreatitis in Japan2014

    • Author(s)
      Kazuhiro Kikuta, Atsushi Masamune, Shin Hamada, Tooru Shimosegawa
    • Organizer
      APA/JPS 45th anniversary meeting
    • Place of Presentation
      Hawaii (USA)
    • Year and Date
      2014-11-05 – 2014-11-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] 急性膵炎発症早期の造影CTによる膵壊死予測診断能2014

    • Author(s)
      菊田和宏、正宗淳、濱田晋、廣田衛久、下瀬川徹
    • Organizer
      第56回日本消化器病学会大会
    • Place of Presentation
      神戸国際展示場・ポートピアホテル・神戸国際会議場 (神戸)
    • Year and Date
      2014-10-23 – 2014-10-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] 全国調査から見た慢性膵炎患者における栄養状態の実態2014

    • Author(s)
      菊田和宏、正宗淳、廣田衛久、下瀬川徹
    • Organizer
      第45回日本膵臓学会大会
    • Place of Presentation
      北九州国際会議場 (小倉)
    • Year and Date
      2014-07-11 – 2014-07-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] 全国調査からみた急性膵炎における生活習慣病2014

    • Author(s)
      菊田和宏、正宗淳、下瀬川徹
    • Organizer
      第100回日本消化器病学会総会
    • Place of Presentation
      東京国際フォーラム (東京)
    • Year and Date
      2014-04-23 – 2014-04-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] 内視鏡下経胃的ネクロセクトミーが有効であった感染性膵壊死の1例2014

    • Author(s)
      竹内智、菊田和宏、粂潔、菅野敦、中野絵里子、有賀啓之、濱田晋、廣田衛久、正宗淳、下瀬川徹
    • Organizer
      第111回日本内科学会総会
    • Place of Presentation
      東京国際フォーラム (東京)
    • Year and Date
      2014-04-11 – 2014-04-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] The nutritional index 'CONUT' is useful for predicting prognosis of acute pancreatitis2013

    • Author(s)
      Kazuhiro Kikuta, Atsushi Masamune, Tooru Shimosegawa
    • Organizer
      米国Digestive Disease Week 2013
    • Place of Presentation
      Orlando, USA
    • Related Report
      2013 Research-status Report
  • [Presentation] Prognosis of acute pancreatitis in Japan based on nationwide survey2013

    • Author(s)
      Kazuhiro Kikuta, Atsushi Masamune, Tooru Shimosegawa
    • Organizer
      第44回日本膵臓学会大会
    • Place of Presentation
      仙台
    • Related Report
      2013 Research-status Report
  • [Presentation] 全国調査に基づく慢性膵炎の膵内外分泌機能と臨床像の解析2013

    • Author(s)
      菊田和宏、正宗淳、下瀬川徹
    • Organizer
      第44回日本膵臓学会大会
    • Place of Presentation
      仙台
    • Related Report
      2013 Research-status Report
  • [Presentation] 全国調査からみた急性膵炎における耐糖能障害2013

    • Author(s)
      菊田和宏、正宗淳、下瀬川徹
    • Organizer
      Japan Digestive Disease Week 2013
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] 全国調査から見た アルコール性急性膵炎の疫学的特徴2013

    • Author(s)
      菊田和宏、正宗淳、粂潔、下瀬川徹
    • Organizer
      第32回アルコール医学生物学研究会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] 高齢者急性膵炎の疫学的検討2013

    • Author(s)
      菊田和宏、正宗淳、下瀬川徹
    • Organizer
      第99回日本消化器病学会総会
    • Place of Presentation
      鹿児島
    • Related Report
      2012 Research-status Report
  • [Presentation] 全国調査をもとにした 急性膵炎の成因と病態、予後に関する疫学的検討2012

    • Author(s)
      菊田和宏、正宗淳、下瀬川徹
    • Organizer
      第43回日本膵臓学会大会
    • Place of Presentation
      山形
    • Related Report
      2012 Research-status Report
  • [Presentation] CONUTによる急性膵炎の栄養評価2012

    • Author(s)
      菊田和宏、正宗淳、下瀬川徹
    • Organizer
      第54回日本消化器病学会大会
    • Place of Presentation
      神戸
    • Related Report
      2012 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi