Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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Outline of Final Research Achievements |
To clarify the role of pancreatic stellate cells for the progression of pancreatic endocrine and exocrine dysfunction, the role of kindlin-2, a key regulator for integrin signaling, in pancreatic stellate cells was studied. Pancreatic stellate cells expressed kindlin-2. The decreased expression of kindlin-2 inhibited the migration of pancreatic stellate cells. Kindlin-2 may have a role in the pancreatic microenvironment. The epidemiological association between pancreatic dysfunction and pancreatitis was also studied. Sixty five point seven percent and 45.7% of chronic pancreatitis patients who were diagnosed as definite chronic pancreatitis within a year showed pancreatic exocrine and endocrine dysfunction, respectively. Acute pancreatitis patients had higher morbidity of diabetes mellitus than normal population. Idiopathic or elder acute pancreatitis patients with diabetes mellitus had a higher mortality.
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