Elucidation of the biological function of non-coding repeat RNA in pancreatic cancer using mouse models
Project/Area Number |
24591005
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Gastroenterology
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Research Institution | The University of Tokyo |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
OTSUKA Motoyuki 東京大学, 医学部附属病院消化器内科, 助教 (90518945)
IJICHI Hideaki 東京大学, 医学部附属病院消化器内科, 助教 (70463841)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 膵癌 / 非コードRNA / 染色体分裂異常 |
Outline of Final Research Achievements |
Repeat RNA, one of the non-coding RNAs which express in pancreatic cancer tissues, is expressed exclusively in the cancerous tissues. Its expression was not detected in the normal pancreas tissues. Thus, we hypothesized that this repeat RNA may be involved in the parthenogenesis of the pancreatic cancer. To clarify this, we constructed onverexpression system of this repeat RNA in culture cells. We observed deregulated chromatin division and impaired repair of the damaged DNA in cells, which may contribute to the malignant phenotype of cancer cells.
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Report
(4 results)
Research Products
(14 results)
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[Journal Article] Risk factors for post-ERCP pancreatitis in wire-guided cannulation for therapeutic biliary ERCP.2015
Author(s)
Nakai Y, Isayama H, Sasahira N, Kogure H, Sasaki T, Yamamoto N, Saito K, Umefune G, Akiyama D, Kawahata S, Matsukawa M, Saito T, Hamada T, Takahara N, Mizuno S, Miyabayashi K, Mohri D, Hirano K, Tada M, Koike K.
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Journal Title
Gastrointest Endosc.
Volume: 81
Issue: 1
Pages: 119-26
DOI
Related Report
Peer Reviewed
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[Journal Article] Endoscopic minor papilla balloon dilation for the treatment of symptomatic pancreas divisum.2014
Author(s)
Yamamoto N, Isayama H, Sasahira N, Tsujino T, Nakai Y, Miyabayashi K, Mizuno S, Kogure H, Sasaki T, Hirano K, Tada M, Koike K.
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Journal Title
Pancreas.
Volume: 43
Issue: 6
Pages: 927-30
DOI
Related Report
Peer Reviewed
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[Journal Article] Transmural biliary drainage can be an alternative to transpapillary drainage in patients with an indwelling duodenal stent.2014
Author(s)
Hamada T, Isayama H, Nakai Y, Kogure H, Yamamoto N, Kawakubo K, Takahara N, Uchino R, Mizuno S, Sasaki T, Togawa O, Matsubara S, Ito Y, Hirano K, Tsujino T, Tada M, Koike K.
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Journal Title
Dig Dis Sci.
Volume: 59
Issue: 8
Pages: 1931-8
DOI
Related Report
Peer Reviewed
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[Journal Article] Prognostic nomogram for nonresectable pancreatic cancer treated with gemcitabine-based chemotherapy2014
Author(s)
Hamada T(1), Nakai Y(1), Yasunaga H(2), Isayama H, Matsui H, Takahara N, Sasaki T, Takagi K, Watanabe T, Yagioka H, Kogure H, Arizumi T, Yamamoto N, Ito Y, Hirano K, Tsujino T, Tada M, Koike K.
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Journal Title
Br J Cancer
Volume: in press
Issue: 8
Pages: 1943-9
DOI
Related Report
Peer Reviewed
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[Journal Article] Slow Pull Versus Suction in Endoscopic Ultrasound-Guided Fine-Needle Aspiration of Pancreatic Solid Masses2014
Author(s)
Nakai Y, Isayama H, Chang KJ, Yamamoto N, Hamada T, Uchino R, Mizuno S, Miyabayashi K, Yamamoto K, Kawakubo K, Kogure H, Sasaki T, Hirano K, Tanaka M, Tada M, Fukayama M, Koike K.
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Journal Title
Dig Dis Sci.
Volume: in press
Related Report
Peer Reviewed
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[Journal Article] A retrospective study of S-1 and oxaliplatin combination chemotherapy in patients with refractory pancreatic cancer2013
Author(s)
Takahara N, Isayama H, Nakai Y, Sasaki T, Hamada T, Uchino R, Mizuno S, Miyabayashi K, Kogure H, Yamamoto N, Sasahira N, Hirano K, Ijichi H, Tateishi K, Tada M, Koike K.
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Journal Title
Cancer Chemother Pharmacol.
Volume: 72(5)
Issue: 5
Pages: 985-90
DOI
Related Report
Peer Reviewed
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[Journal Article] Diabetes is a useful diagnostic clue to improve the prognosis of pancreatic cancer2013
Author(s)
Mizuno S, Nakai Y, Isayama H, Takahara N, Miyabayashi K, Yamamoto K, Kawakubo K, Mohri D, Kogure H, Sasaki T, Yamamoto N, Sasahira N, Hirano K, Tsujino T, Ijichi H, Tateishi K, Tada M, Koike K
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Journal Title
Pancreatology
Volume: 13(3)
Issue: 3
Pages: 285-9
DOI
Related Report
Peer Reviewed
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[Journal Article] Preliminary report on a new, fully covered, metal stent designed for the treatment of pancreatic fluid collections.2013
Author(s)
Yamamoto N(1), Isayama H, Kawakami H, Sasahira N, Hamada T, Ito Y, Takahara N, Uchino R, Miyabayashi K, Mizuno S, Kogure H, Sasaki T, Nakai Y, Kuwatani M, Hirano K, Tada M, Koike K.
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Journal Title
Gastrointest Endosc.
Volume: 77(5)
Issue: 5
Pages: 809-14
DOI
Related Report
Peer Reviewed
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[Journal Article] Uridine diphosphate glucuronosyl transferase 1 family polypeptide A1 gene (UGT1A1) polymorphisms are associated with toxicity and efficacy in irinotecan monotherapy for refractory pancreatic cancer2013
Author(s)
Takahara N, Nakai Y, Isayama H, Sasaki T, Satoh Y, Takai D, Miyabayashi K, Mohri D, Kawakubo K, Kogure H, Yamamoto N, Sasahira N, Hirano K, Ijichi H, Tada M, Yatomi Y, Koike K
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Journal Title
Cancer Chemotherapy and Pharmacology
Volume: 71
Issue: 1
Pages: 85-92
DOI
Related Report
Peer Reviewed
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