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study on pancreatic cancer using adiponectin: risk factor analysis and development of new treatment

Research Project

Project/Area Number 24591011
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Gastroenterology
Research InstitutionOsaka University

Principal Investigator

KENJI WATABE  大阪大学, 医学部附属病院, 准教授 (50379244)

Co-Investigator(Kenkyū-buntansha) TSUJII Masahiko  大阪大学, 医学系研究科, 准教授 (40303937)
KISO Shinnichi  大阪大学, 医学系研究科, 特任准教授 (40335352)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords膵臓癌 / 肥満 / 内臓脂肪 / アディポネクチン / アポトーシス / 膵星細胞 / 膵癌
Outline of Final Research Achievements

In Japan, more than 30,000 people die from pancreatic cancer. Obesity is a risk factor for the development and growth of pancreatic cancer. The mechanisms underlying the association between obesity and pancreatic cancer have been investigated through hormonal, inflammatory and immunological changes in obesity. Adiponectin is an adipose tissue-derived secretory hormone. In this study, we investigated the role of adiponectin in the growth of pancreatic cancer.
We examined the effect of adiponectin on the growth of Pan02 murine pancreatic cancer cells using recombinant adiponectin and adiponectin knockout mice. The in vitro treatment of Pan02 cells with adiponectin inhibited cellular proliferation that was accompanied by increased apoptosis. Transplantation of Pan02 cells into the pancreas of knockout mice resulted in a larger tumor volume with fewer apoptotic cells compared with wild type mice. The results indicate that adiponectin directly suppresses the proliferation of Pan02 cells.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (7 results)

All 2015 2014 2013 2012 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Remarks (1 results)

  • [Journal Article] 5FU resistance abrogates the amplified cytotoxic effects induced by inhibiting checkpoint kinase 1 in p53‑mutated colon cancer cells.2015

    • Author(s)
      Akasaka T, Tsujii M, Kondo J, Hayashi Y, Ying J, Lu Y, Kato M, Yamada T, Yamamoto S, Inoue T, Tsujii Y, Maekawa A, Fujinaga T, Shiraishi E, Hiyama S, Inoue T, Shinzaki S, Watabe K, Nishida T, Iijima H, Takehara T.
    • Journal Title

      Int J Oncol.

      Volume: 46 Issue: 1 Pages: 63-70

    • DOI

      10.3892/ijo.2014.2693

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The effectiveness of an anti-human IL-6 receptor monoclonal antibody combined with chemotherapy to target colon cancer stem-like cells.2015

    • Author(s)
      Ying J, Tsujii M, Kondo J, Hayashi Y, Kato M, Akasaka T, Inoue T, Shiraishi E, Inoue T, Hiyama S, Tsujii Y, Maekawa A, Kawai S, Fujinaga T, Araki M, Shinzaki S, Watabe K, Nishida T, Iijima H, Takehara T.
    • Journal Title

      Int J Oncol.

      Volume: 46 Issue: 4 Pages: 1151-1159

    • DOI

      10.3892/ijo.2015.2851

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adiponectin inhibits murine pancreatic cancer growth.2014

    • Author(s)
      Kato M, Watabe K, Tsujii M, Funahashi T, Shimomura I, Takehara T.
    • Journal Title

      Dig Dis Sci.

      Volume: 59 Issue: 6 Pages: 1192-1196

    • DOI

      10.1007/s10620-014-3175-6

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gastric Contraction Imaging System Using a 3-D Endoscope2014

    • Author(s)
      Kayo Yoshimoto, Kenji Yamada, Kenji Watabe, Maki Takeda, Takahiro Nishimura, Michiko Kido, Toshiaki Nagakura, Hideya Takahashi, Tsutomu Nishida, Hideki Iijima, Masahiko Tsujii, Tetsuo Takehara, Yuko Ohno
    • Journal Title

      IEEE Journal of Translational Engineering in Health and Medicine

      Volume: vol.2, no.1 Pages: 1-8

    • DOI

      10.1109/jtehm.2014.2298852

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Adiponectin negatively correlates with alcoholic and non-alcoholic liver dysfunction : Health check-up study of Japanese men2013

    • Author(s)
      Hamano M, Kiso S, Yoshida Y, Watabe K,他19人
    • Journal Title

      Hepatol Res

      Volume: 43(3) Issue: 3 Pages: 238-48

    • DOI

      10.1111/j.1872-034x.2012.01066.x

    • NAID

      10031183465

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Protective role of adiponec t in against ethanol-induced gastric injury in mice.2012

    • Author(s)
      Yamamoto S, ffatabe K, Araki H, et al.
    • Journal Title

      Am J Physiol Gastrointest Liver Physiol.

      Volume: 302(Epub 2012 Feb 9) Issue: 8 Pages: G773-G780

    • DOI

      10.1152/ajpgi.00324.2011

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Remarks] 肥満・内臓脂肪蓄積と膵臓癌化学療法応答の関連性を検討する臨床研究

    • URL

      http://www.med.osaka-u.ac.jp/pub/gh/research_jisyu_watabe01.html

    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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