| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
|---|
| Outline of Final Research Achievements |
It has been reported that lumican expression level showed positive correlation with cell growth of pancreatic ductal adenocarcinoma (PDAC) cells and showed negative correlation with cell invasion of PDAC cells. In this study, we performed global shotgun proteomic analysis using lumican-regulated PANC-1 cells to examine the effect of lumican on cell growth and invasion in PDAC cells. As a result of proteomics, 24 proteins were identified as candidate proteins which expression was regulated by lumican, and these candidate proteins included protein which is known apoptosis marker and protein which regulate MMP-9 activation. Thus, lumican might be involved in cell growth and invasion to regulate cell apoptosis and these proteins expression.
|
