| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
To clarify the role of endoplasmic reticulum stress in the development of acute pancreatitis, we created a murine model induced by administration of cerulein and lipopolysaccharide. GRP78 and CHOP proteins increased in the pancreas of mice with pancreatitis. In contrast, administration of an inhibitor of dephosphorylation of eIF2α suppressed pancreatitis, coupled with the increase in phosphorylated eIF2α and ATF4 and the decrease in GRP78 and CHOP protein. Suppression of protein synthesis and increase in ER stress-induced proteins by administration of the inhibitor are supposed to be involved in amelioration of pancreatitis, suggesting the usefulness of augmentation of PERK signaling pathway for the treatment of acute pancreatitis.
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