| Project/Area Number |
24591023
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Keio University |
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Principal Investigator |
KO Shigeru 慶應義塾大学, 医学部, 講師 (90402578)
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| Co-Investigator(Kenkyū-buntansha) |
KO Minoru 慶應義塾大学, 医学部, 教授 (50631199)
NAKATAKE Yuhki 慶應義塾大学, 医学部, 助教 (20415251)
ISHIGURO Hiroshi 名古屋大学, 総合保健体育科学センター, 教授 (90303651)
YAMAMOTO Akiko 名古屋大学, 総合保健体育科学センター, 准教授 (60402385)
NIIDA Shunpei 独立行政法人国立長寿医療研究センター, バイオバンク, バイオバンク長 (10137630)
MATSUURA Toshihiro 独立行政法人国立長寿医療研究センター, 消化機能診療部, 部長 (80501626)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 膵組織再生 / 組織幹細胞 / 膵組織幹細胞 / 幹細胞マーカー / 膵臓 / 幹/前駆細胞 / ZSCAN4 / 膵炎 / LGR5 / BMI1 |
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| Outline of Final Research Achievements |
We have examined the expression and lozalization pattern of stem/progenitor cell marker, LGR5, in human and mouse pancreas. In the human and mouse pancreas, LGR5 is localized in a very limited subpopulation of cells in the pancreas together with other stem/progenitor cell marker such as BMI1. These stem/progenitor cell marker positive cells are also positive for exocrine cell marker amylase or endocrine cell marker insulin or glucagon. These finding suggest that in the human or mouse pancreas, there is no isolated stem/progenitor cells in the organ but the subpopulation of mature differentiated cells are the cells that are responsible for tissue repair/regeneration.
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