| Project/Area Number |
24591028
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | 独立行政法人国立病院機構(東京医療センター臨床研究センター) (2014)
Keio University (2012-2013) |
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Principal Investigator |
URAOKA Toshio 独立行政法人国立病院機構(東京医療センター臨床研究センター), 政策医療企画研究部, 医師 (80448216)
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| Co-Investigator(Kenkyū-buntansha) |
YAHAGI Naohisa 慶應義塾大学, 医学部, 教授 (90292937)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | 消化器内視鏡治療 / 内視鏡切除 / 偶発症 / 後出血 / ペプチド溶液 / 組織修復 / 消化器内視鏡 / 内視鏡治療 / 早期胃癌 / 再生医療 / 消化管内視鏡治療 / 早期消化管癌 |
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| Outline of Final Research Achievements |
We investigated that the safety and efficacy of a novel fully-synthetic and self-assembled peptide solution for complications such as delayed bleeding after endoscopic resection in the gastrointestinal tract. We conducted an experimental study using live pigs and then a clinical trial, step by step.
An experimental study demonstrated the safety and efficacy of a novel this solution. Furthermore, a clinical study demonstrated that the use of this solution reduced post-ESD bleeding rate and promoted ulcer healing. There were also no adverse effects related with PuraMatrix use. Those study results had been presented at two international and a domestic meetings.
For a practical application of this solution in the future, CE marking was obtained for this solution last year of this study period in Europe. We’ll have a large scale-international multicenter study within a several years. In addition, we have been developing a delivery catheter of this solution for ideal application of that.
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