Suppression of Cardiovascular Remodeling by Base Excision Repair of Oxidative DNA Damage and Heat Shock Protein
| Project/Area Number |
24591031
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 酸化ストレス / 心血管リモデリング / DNA塩基損傷 / APE1 / 内皮前駆細胞 / ＡＰＥ１ |
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| Outline of Final Research Achievements |
The aim of this study was to establish a new strategy for control of cardiovascular remodeling through the base excision repair of oxidative DNA damage and heat shock protein. The main target protein was Apurinic/apyrimidinic Endonuclease 1 (APE1). The adhesion property of endothelial progenitor cells (EPCs) was maintained depending on APE1 activity. The neo-intimal formation in the wire-injured femoral arteries of mice, i.e. intima/media ratio was significantly suppressed by APE1. Heat shock protein 72 was expressed mainly in the media of APE1-applied wire-injured lesion, accompanied by suppression of chemocaines and NADPH oxidase, suggesting the suppression of inflamation and oxidative stress. We proposed a potential new strategy of modifying APE1 mediated mechanism for the suppression of cardiovascular remodeling.
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Report
(4 results)
Research Products
(52 results)
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[Journal Article] Nifedipine controlled-release 40 mg b.i.d. in Japanese patients with essential hypertension who responded insufficiently to nifedipine controlled-release 40 mg q.d.: a phase III, randomized, double-blindand parallel-group study.2014
Author(s)
Shimamoto K, Hasebe N, Ito S,Kario K, Kimura K, Dohi Y, Kawano Y, Rakugi H, Horiuchi M, Imaizumi T, Ohya Y.
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Journal Title
Hypertens Res.
Volume: 37
Issue: 1
Pages: 69-75
DOI
Related Report
Peer Reviewed
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[Journal Article] Combination of antihypertensive therapy in the elderly, multicenter investigation (CAMUI) trial: results after 1 year.2013
Author(s)
Sato N, Saijo Y, Sasagawa Y, Morimoto H, Takeuchi T, Sano H, Koyama S, Takehara N, Morita K, Sumitomo K, Maruyama J, Kikuchi K, Hasebe N; the CAMUI investigators.
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Journal Title
J Hypertens.
Volume: Epub ahead of print
Issue: 6
Pages: 1245-55
DOI
Related Report
Peer Reviewed
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[Journal Article] Combination of antihypertensive therapy in the elderly, multicenter investigation (CAMUI) trial: results after 1 year2013
Author(s)
Sato N, Saijo Y, Sasagawa Y, Morimoto H, Takeuchi T, Sano H, Koyama S, Takehara N, Morita K, Sumitomo K, Maruyama J, Kikuchi K, Hasebe N
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Journal Title
J Hypertens
Volume: 31
Pages: 1245-1255
Related Report
Peer Reviewed
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[Journal Article] Impaired ventricular repolarization dynamics in patients with early repolarization syndrome.2013
Author(s)
Talib AK, Sato N, Asanome A, Myojo T, Nishiura T, Yamaki M, Nakagawa N, Sakamoto N, Ota H, Tanabe Y, Takeuchi T, Kawamura Y, Hasebe N
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Journal Title
J Cardiovasc Electrophysiol
Volume: 24
Pages: 556-561
Related Report
Peer Reviewed
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[Journal Article] Prostacyclin stimulated integrin-dependent angiogenic effects of endothelial progenitor cells and mediated potent circulation recovery in ischemic hind limb model2013
Author(s)
Aburakawa Y, Kawabe J, Okada M, Yamauchi A, Asanome A, Kabara M, Matsuki M, Takehara N, Nakagawa N, Okumura S, Minami Y, Mizukami Y, Yuhki K, Ushikubi F, Hasebe N
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Journal Title
Circ J
Volume: 77
Pages: 1053-1062
NAID
Related Report
Peer Reviewed
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[Journal Article] Impaired Ventricular Repolarization Dynamics in Patients with Early Repolarization Syndrome.2012
Author(s)
Talib AK, Sato N, Asanome A, Myojo T, Nishiura T, Yamaki M, Nakagawa N, Sakamoto N, Ota H, Tanabe Y, Takeuchi T, Kawamura Y, Hasebe N.
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Journal Title
J Cardiovasc Electrophysiol.
Volume: Epub ahead of print
Issue: 5
Pages: 556-61
DOI
Related Report
Peer Reviewed
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[Journal Article] Recurrent ventricular fibrillation related to hypokalemia in early repolarization syndrome.2012
Author(s)
Myojo T, Sato N, Nimura A, Matsuo A, Taniguchi O, Nakamura H, Karim Talib A, Sakamoto N, Takeuchi T, Kawamura Y, Hasebe N.
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Journal Title
Pacing Clin Electrophysiol.
Volume: 35
Issue: 8
Pages: 234-238
DOI
Related Report
Peer Reviewed
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