ovel strategy for catheter interventional treatment of chronic thromboembolic pulmonary hypertension guided by optical coherence tomography imaging

• Project/Area Number: 24591032
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Tohoku University
• Principal Investigator: SUGIMURA Koichiro 東北大学, 大学病院, 助教 (60375079)
• Co-Investigator(Kenkyū-buntansha): FUKUMOTO Yoshihiro 久留米大学, 医学部, 教授 (70363372)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 経皮的肺動脈形成術 / 慢性血栓塞栓性肺高血圧症 / 光干渉断層法 / 循環器・高血圧

Outline of Final Research Achievements

Inoperable chronic thromboembolic pulmonary hypertension (CTEPH) still remains a fatal disease due to the lack of effective treatments. Optical coherence tomography (OCT) is an interferometer-based imaging modality.In our aim, in order to develop an effective and safe interventional treatment for CTEPH, we examined the effectiveness of our modified methods of OCT-guided percutaneous transluminal pulmonary angioplasty (PTPA). OCT examinations clearly showed the images of typical organic thrombus. We reported the effectiveness of PTPA in ERS international congress 2013in Barcelona. We examined thrombin-activated fibrinolysis inhibitor (TAFI) in blood sample from patients with CTEPH, and our results indicate that TAFI may be involved in the pathogenesis of CTEPH. We reported our results in AHA scientific sessions 2013.
Conclusion: OCT-guided PTPA markedly ameliorates pulmonary hemodynamics and RV functions in patients with inoperable CTEPH

Research Products

• [Journal Article] Platelets are highly activated in patients of chronic thromboembolic pulmonary hypertension (CTEPH). (2014)
  • Author(s): Yaoita N, Shirakawa R, Fukumoto Y, Sugimura K, Miyata S, Miura Y, Nochioka K, Miura M, Tatebe S, Aoki T, Miyamichi-Yamamoto S, Satoh K, Kimura T, Shimokawa H, Horiuchi H.
  • Journal Title: Arterioscler Thromb Vasc Biol. Volume: 34 Issue: 11 Pages: 2486-2494
  • DOI: 10.1161/atvbaha.114.304404
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] OCT imaging for the management of pulmonary hypertension. (2014)
  • Author(s): Dai Z, Fukumoto Y, Tatebe S, Sugimura K, Miura Y, Nochioka K, Aoki T, Miyamichi-Yamamoto S, Yaoita N, Satoh K, Shimokawa H.
  • Journal Title: JACC-Cardiovasc Imaging. Volume: 7 Issue: 8 Pages: 843-845
  • DOI: 10.1016/j.jcmg.2014.01.020
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Visualization of complete regression of pulmonary arterial remodeling on optical coherence tomography in a patient with pulmonary arterial hypertension (2014)
  • Author(s): Dai Z, Sugimura K, Fukumoto Y, Tatebe S, Miura Y, Nochioka K, Aoki T, Miyamichi-Yamamoto S, Yaoita N, Satoh K, Shimokawa H.
  • Journal Title: Circ J Volume: ７８ Pages: 2771-3
  • NAID: 130004700253
  • Peer Reviewed
• [Journal Article] Histopathological examination by lung biopsy for the evaluation of operability and postoperative prognosis in patients with chronic thromboembolic pulmonary hypertension (2014)
  • Author(s): Yamaki S1, Ando M, Fukumoto Y, Higuchi Y, Kaneko K, Maeda K, Shimokawa H.
  • Journal Title: Circ J Volume: 78 Pages: 476-82
  • NAID: 130003382220
  • Peer Reviewed
• [Journal Article] Optical coherence tomography is superior to intravascular ultrasound for diagnosis of distal-type chronic thromboembolic pulmonary hypertension. (2013)
  • Author(s): Tatebe S1, Fukumoto Y, Sugimura K, Miura Y, Nochioka K, Aoki T, Miura M, Yamamoto S, Yaoita N, Satoh K, Shimokawa H.
  • Journal Title: Circ J Volume: 77 Pages: 1081-3
  • NAID: 10031139014
  • Peer Reviewed
• [Journal Article] Three-dimensional-optical coherence tomography imaging of chronic thromboembolic pulmonary hypertension. (2013)
  • Author(s): Sugimura K1, Fukumoto Y, Miura Y, Nochioka K, Miura M, Tatebe S, Aoki T, Satoh K, Yamamoto S, Yaoita N, Shimokawa H.
  • Journal Title: Eur Heart J Volume: ３４ Pages: 2121-2121
  • Peer Reviewed
• [Journal Article] Optical Coherence Tomography Is Superior to Intravascular Ultrasound for Diagnosis of Distal-Type Chronic Thromboembolic Pulmonary Hypertension (2013)
  • Author(s): Tatebe S
  • Journal Title: Circulation Journal Volume: 77 Issue: 4 Pages: 1081-1083
  • DOI: 10.1253/circj.CJ-12-1493
  • NAID: 130003361592
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed
• [Presentation] Novel Role of Platelets in the Pathogenesis of Chronic Thromboembolic Pulmonary Hypertension (2014)
  • Author(s): Nobuhiro Yaoita, Yoshihiro Fukumoto, Shunsuke Tatebe, Saori Yamamoto, Tatsuo Aoki, Masanobu Miura, Kotaro Nochioka, Koichiro Sugimura, Kimio Satoh, Hisanori Horiuchi, Hiroaki Shimokawa
  • Organizer: American Heart Association Scientific Sessions
  • Place of Presentation: Chicago, USA
  • Year and Date: 2014-11-15 – 2014-11-19
• [Presentation] Percutaneous Transluminal Balloon Angioplasty Ameliorates Metabolic and Renal Dysfunctions Associated with Hemodynamic Improvement in Patients with Chronic Thromboembolic Pulmonary Hypertension (2014)
  • Author(s): Shunsuke Tatebe, Koichiro Sugimura, Kotaro Nochioka, Masanobu Miura, Saori Yamamoto, Nobuhiro Yaoita, Haruka Sato, Kimio Satoh, Hiroaki Shimokawa
  • Organizer: American Heart Association Scientific Sessions
  • Place of Presentation: Chicago, USA
  • Year and Date: 2014-11-15 – 2014-11-19
• [Presentation] Percutaneous Transluminal Pulmonary Angioplasty Improves Hemodynamics and Right Ventricular Function in Patients with Chronic Thromboembolic Pulmonary Hypertension One Year Follow-up Study (2014)
  • Author(s): Masanobu Miura, Koichiro Sugimura, Kotaro Nochioka, Tatsuo Aoki, Shunsuke Tatebe, Saori Yamamoto, Hironobu Yaoita, Haruka Sato, Kimio Sato, Hiroaki Shimokawa
  • Organizer: American Heart Association Scientific Sessions
  • Place of Presentation: Chicago, USA
  • Year and Date: 2014-11-15 – 2014-11-19
• [Presentation] 肺高血圧症における右不全 (2014)
  • Author(s): 杉村宏一郎
  • Organizer: 心不全学会学術集会
  • Place of Presentation: 大阪市
  • Year and Date: 2014-10-10 – 2014-10-12
  • Invited
• [Presentation] 慢性血栓塞栓性肺高血圧症に対する経皮的肺動脈形成術と右室機能に関する検討 (2014)
  • Author(s): 三浦正暢 杉村宏一郎 後岡広太郎 青木竜男
  • Organizer: 日本心臓病学会
  • Place of Presentation: 仙台市
  • Year and Date: 2014-09-26 – 2014-09-28
• [Presentation] 慢性肺血栓塞栓性肺高血圧症に対する薬物療法の効果 (2014)
  • Author(s): 青木竜男、杉村宏一郎、佐藤遥、矢尾板信裕、山本沙織、建部俊介、三浦正暢、後岡広太郎、佐藤 遥、佐藤公雄、下川宏明
  • Organizer: 日本心臓病学会
  • Place of Presentation: 仙台市
  • Year and Date: 2014-09-26 – 2014-09-28
• [Presentation] Percutaneous Transluminal Pulmonary Angioplasty Improves Right Ventricular Function in Patients with Inoperable Chronic Thromboembolic Pulmonary Hypertension (2014)
  • Author(s): Masanobu Miura, Koichiro Sugimura, Kotaro Nochioka, Syunsuke Tatebe, Saori Yamamoto,
  • Organizer: European Society of Cardiology Congress
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2014-08-30 – 2014-09-03
• [Presentation] Usefulness of Optical Coherence Tomography Imaging in Chronic Thromboembolic Pulmonary Hypertension (2014)
  • Author(s): Koichiro Sugimura, Kotaro Nochioka, Syunsuke Tatebe, Saori Yamamoto, Masanobu Miura, Takeshi Kato, Kimio Satoh, Hiroaki Shimokawa
  • Organizer: European Society of Cardiology Congress
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2014-08-30 – 2014-09-03
• [Presentation] Usefulness of Optical Coherence Tomography Imaging for Percutaneous Transluminal Pulmonary Angioplasty in Patients with Chronic Thromboembolic Pulmonary Hypertension (2014)
  • Author(s): Koichiro Sugimura, Kotaro Nochioka, Syunsuke Tatebe, Saori Yamamoto, Masanobu Miura, Takeshi Kato, Kimio Satoh, Hiroaki Shimokawa
  • Organizer: Japanese Association of Cardiovascular Intervention and Therapeutics
  • Place of Presentation: 名古屋市
  • Year and Date: 2014-07-24 – 2014-07-26
  • Invited
• [Presentation] Usefulness of Optical Coherence Tomography for Diagnosis and Treatment in Patients with Chronic Thromboembolic Pulmonary Hypertension (2014)
  • Author(s): Koichiro Sugimura, Yoshihiro Fukumoto, Yutaka Miura, Kotaro Nochioka, Tatsuo Aoki, Shunsuke Tatebe, Saori Yamamoto, Kimio Satoh, Hiroaki Shimokawa
  • Organizer: International Vascular Biology Meeting
  • Place of Presentation: 京都市
  • Year and Date: 2014-04-14 – 2014-04-17
• [Presentation] Usefulness of Optical Coherence Tomography for Diagnosis and Treatment in Chronic Thromboembolic Pulmonary Hypertension (2013)
  • Author(s): Koichiro Sugimura, Yoshihiro Fukumoto, Yutaka Miura, Kotaro Nochioka, Shunsuke Tatebe, Saori Yamamoto, Masanobu Miura, Kimio Satoh, Hiroaki Shimokawa
  • Organizer: 欧州呼吸器学会議 (ERS 2013)
  • Place of Presentation: Barcelona, Spain
• [Presentation] Optical Coherence Tomography Is Useful for Diagnosis and Treatment in Patients with Chronic Thromboembolic Pulmonary Hypertension (2013)
  • Author(s): Koichiro Sugimura, Yoshihiro Fukumoto, Yutaka Miura, Kotaro Nochioka, Tatsuo Aoki, Shunsuke Tatebe, Saori Yamamoto, Kimio Satoh, Hiroaki Shimokawa
  • Organizer: 米国胸部学会議 (ATS 2013)
  • Place of Presentation: Philadelphia, USA
• [Presentation] Resistance of thrombus to fibrinolysis in patients with chronic thromboembolic pulmonary hypertension -Possible involvement of thrombin-activated fibrinolysis inhibitor (TAFI)- (2013)
  • Author(s): 13.Yaoita N, Fukumoto Y, Kawamura T, Horiuchi H, Shimokawa H
  • Organizer: American Heart Association (AHA) Scientific Sessions
  • Place of Presentation: Dallas, USA
• [Presentation] Usefulness of Optical Coherence Tomography for Diagnosis and Treatment of Chronic Thromboembolic Pulmonary Hypertension (2013)
  • Author(s): Koichiro Sugimura
  • Organizer: 2013 醍7回日本循環器学会学術集会
  • Place of Presentation: 横浜
• [Presentation] Remarkable Effectiveness of Percutaneous Transluminal Pulmonary Angioplasty for Pulmonary Hemodynamics and Long-Term Prognosis in Patients with Distal-type Chronic Thromboembolic Pulmonary Hypertension (2012)
  • Author(s): Koichiro Sugimura
  • Organizer: ESC congress 2012
  • Place of Presentation: Munich,Germany
• [Remarks] 東北大学大学院循環器内科学 東北大学病院循環器内科
  • URL: http://www.cardio.med.tohoku.ac.jp/index.html
• [Remarks] 東北大学大学院循環器内科学 東北大学循環器内科
  • URL: http://www.cardio.med.tohoku.ac.jp/index.html