| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Inoperable chronic thromboembolic pulmonary hypertension (CTEPH) still remains a fatal disease due to the lack of effective treatments. Optical coherence tomography (OCT) is an interferometer-based imaging modality.In our aim, in order to develop an effective and safe interventional treatment for CTEPH, we examined the effectiveness of our modified methods of OCT-guided percutaneous transluminal pulmonary angioplasty (PTPA). OCT examinations clearly showed the images of typical organic thrombus. We reported the effectiveness of PTPA in ERS international congress 2013in Barcelona. We examined thrombin-activated fibrinolysis inhibitor (TAFI) in blood sample from patients with CTEPH, and our results indicate that TAFI may be involved in the pathogenesis of CTEPH. We reported our results in AHA scientific sessions 2013.
Conclusion: OCT-guided PTPA markedly ameliorates pulmonary hemodynamics and RV functions in patients with inoperable CTEPH
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