The clinical significance of left ventricular longitudinal strain as heart failure prognosticator beyond ejection fraction

• Project/Area Number: 24591035
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: University of Tsukuba
• Principal Investigator: Ishizu Tomoko 筑波大学, 医学医療系, 講師 (10507859)
• Co-Investigator(Kenkyū-buntansha): Seo Yoshihiro 筑波大学, 医学医療系, 准教授 (40375499)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
• Keywords: 心不全 / 心エコー / 心エコー図 / スペックルトラッキング / 心筋ストレイン / 心不全の画像診断研究 / 前向きコホート研究 / 観察研究

Outline of Final Research Achievements

The purpose of the present study was to assess the prognostic significance of global longitudinal strain in patients with acute decompensated heart failure. Eight hundred thirty eight patients were included and followed up until one year except for only eight patients who were lost of follow up. Major cardiovascular events, including unplanned hospitalization of heart failure, were observed in 269 patients (32%).The echocardiographic myocardial strain analysis in now underway, and one hundred fifty six analysis were completed. According the current results, global longitudinal strain dose not show significant difference between the patients with and without events. On the other hand, the endocardial circumferential strain are significantly deteriorated in the patients with events in compared to without events. These current results indicated that the longitudinal strain could not be the prognostic indicator in patients with stage C heart failure.

Research Products

• [Journal Article] Subendocardial Systolic Dysfunction in Asymptomatic Normotensive Diabetic Patients (2015)
  • Author(s): Enomoto M, Ishizu T, Seo Y, Yamamoto M, Suzuki H, Shimano H, Kawakami Y, Aonuma K.
  • Journal Title: Circulation Journal Volume: 79 Issue: 8 Pages: 1749-1755
  • DOI: 10.1253/circj.CJ-15-0012
  • NAID: 130005089367
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access
• [Journal Article] Utility of Ultrasonography in Point of Care for Cardiovascular Disease (2015)
  • Author(s): Ishizu T and Kawakami Y.
  • Journal Title: Rinsho Byori Volume: 63 Pages: 709-716
  • NAID: 40020533739
• [Journal Article] Assessment and Treatment of Systemic Right Ventricular Dyssynchrony (2015)
  • Author(s): Ishizu T, Horigome H.
  • Journal Title: Circulation Journal Volume: 79 Issue: 3 Pages: 519-521
  • DOI: 10.1253/circj.CJ-15-0105
  • NAID: 130004927086
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access
• [Journal Article] Prognostic significance of persistent restrictive filling pattern after cardiac resynchronization therapy. (2015)
  • Author(s): Yamamoto M, Seo Y, Ishizu T, Kawamatsu N, Sato K, Sugano A, Atsumi A, Harimura Y, Machino-Ohtsuka T, Sakamaki F and Aonuma K.
  • Journal Title: J Echocardiogr. Volume: 13 Issue: 1 Pages: 20-6
  • DOI: 10.1007/s12574-014-0234-0
  • Peer Reviewed / Open Access
• [Journal Article] Left ventricular strain and transmural distribution of structural remodeling in hypertensive heart disease. (2014)
  • Author(s): Ishizu T, Seo Y, Kameda Y, Kawamura R, Kimura T, Shimojo N, Xu D, Murakoshi N and Aonuma K.
  • Journal Title: Hypertension Volume: 63 Issue: 3 Pages: 500-6
  • DOI: 10.1161/hypertensionaha.113.02149
  • Peer Reviewed
• [Journal Article] Prognostic value of global longitudinal strain in paradoxical low-flow, low-gradient severe aortic stenosis with preserved ejection fraction (2014)
  • Author(s): Sato K, Seo Y, Ishizu T, Takeuchi M, Izumo M, Suzuki K, Yamashita E, Oshima S, Akashi YJ, Otsuji Y, Aonuma K.
  • Journal Title: Circ J Volume: 78 Pages: 2750-9
  • NAID: 130004693850
  • Peer Reviewed / Open Access
• [Journal Article] Current status of 3-dimensional speckle tracking echocardiography: a review from our experiences (2014)
  • Author(s): Seo Y, Ishizu T, Aonuma K.
  • Journal Title: J Cardiovasc Ultrasound Volume: 22 Issue: 2 Pages: 49-50
  • DOI: 10.4250/jcu.2014.22.2.49
  • Peer Reviewed
• [Journal Article] Right ventricular remodeling due to pulmonary regurgitation is associated with reduced left ventricular free wall strain in surgically repaired tetralogy of fallot. (2014)
  • Author(s): Nakamura A, Horigome H, Seo Y, Ishizu T, Sumazaki R.
  • Journal Title: Circ J Volume: 78 Pages: 1960-6
  • NAID: 130004427934
  • Peer Reviewed / Open Access
• [Journal Article] Complex left atrial appendage morphology and left atrial appendage thrombus formation in patients with atrial fibrillation. (2014)
  • Author(s): Yamamoto M, Seo Y, Kawamatsu N, Sato K, Sugano A, Machino-Ohtsuka T, Kawamura R, Nakajima H, Igarashi M, Sekiguchi Y, Ishizu T, Aonuma K.
  • Journal Title: Circ Cardiovasc Imaging Volume: 7 Issue: 2 Pages: 337-43
  • DOI: 10.1161/circimaging.113.001317
  • Peer Reviewed
• [Presentation] Incremental Value of ST-2 to Brain Natriuretic Peptide for Prediction of Prognosis in Patients with Acute Decompensated Heart Failure. (2016)
  • Author(s): Akinori Sugano, Yoshihiro Seo , Tomoko Ishizu, Masayoshi Yamamoto, Yoshie Harimura, Isao Nishi, Hidetaka Nishina, Yuko Fumikura, Yuichi Noguchi, Kazutaka Aonuma.
  • Organizer: European Society of Cardiology
  • Place of Presentation: Roma, Italy
  • Year and Date: 2016-08-27
  • Int'l Joint Research
• [Presentation] Right Ventricular Dysfunction Dominant Subgroup among Heart Failure with Preserved Left Ventricular Ejection Fraction; Prospective Cohort ICAS-HF Registry. (2016)
  • Author(s): Tomoko Ishizu, Yoshihiro Seo, Yuu Yamada Daishi Nakagawa, Masayoshi Yamamoto, Tomoko Machino, Kazutaka Aonuma.
  • Organizer: 第80回日本循環器学会
  • Place of Presentation: 仙台 仙台国際センター
  • Year and Date: 2016-03-18
• [Presentation] The Role of Clinical Scenario to Predict Clinical Outcomes in Acute Decompensated Heart Failure. (2016)
  • Author(s): Daishi Nakagawa, Yoshihiro Seo, Yoshie Harimura, Tomoko Ishizu, Masayoshi Yamamoto, Akinori Sugano, Isao Nishi, Kazutaka Aonuma.
  • Organizer: 第80回日本循環器学会
  • Place of Presentation: 仙台 仙台国際センター
  • Year and Date: 2016-03-18
• [Presentation] Intensive Rhythm Control Based on Catheter Ablation for Atrial Fibrillation Suppresses Adverse Cardiac Events in Patients with HFPEF. (2016)
  • Author(s): Tomoko Machino, Yoshihiro Seo , Masayoshi Yamamoto , Tomoko Ishizu , Kenji Kuroki , Takeshi Machino , Yukio Sekiguchi , Akihiko Nogami , Kazutaka Aonuma.
  • Organizer: 第80回日本循環器学会
  • Place of Presentation: 仙台 仙台国際センター
  • Year and Date: 2016-03-18
• [Presentation] Continuous Tolvaptan Treatment Improves Clinical Outcomes in Patients with Well-Controled Right-Sided Heart Congestion at Discharge. (2016)
  • Author(s): Naoto Kawamatsu. Yoshihiro Seo, Yoshie Harimura, Tomoko Ishizu, Tomofumi Nakatsukasa, Seika Sai, Kimi Sato, Akinori Sugano, Akiko Atsumi, Masayoshi Yamamoto, Tomoko Machino, Daigo Hiraya, Isao Nishi, Kenichi Obara, Kazutaka Aonuma.
  • Organizer: 第80回日本循環器学会
  • Place of Presentation: 仙台 仙台国際センター
  • Year and Date: 2016-03-18
• [Presentation] Hypoalbuminemia as a Poor Prognosticator in Heart Failure with Preserved Ejection Fraction. (2016)
  • Author(s): Akinori Sugano, Yoshihiro Seo , Tomoko Ishizu, Masayoshi Yamamoto, Yoshie Harimura, Isao Nishi, Hidetaka Nishina, Yuko Fumikura, Yuichi Noguchi, Kazutaka Aonuma.
  • Organizer: 第80回日本循環器学会
  • Place of Presentation: 仙台 仙台国際センター
  • Year and Date: 2016-03-18
• [Presentation] Relationship between Pentraxin 3 and Atrial Fibrillation in Patients Hospitalized for Heart Failure: From the ICAS-HF Registry (2015)
  • Author(s): Akinori Sugano, Yoshihiro Seo, Naoto Kawamatsu, Kimi Sato, Seika Sai, Masayoshi Yamamoto, Yoshie Harimura, Hidetaka Nishina, Isao Nishi, Tomoko Ishizu, Yuko Fumikura, Yuichi Noguchi, Kazutaka Aonuma
  • Organizer: 第79回日本循環器学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2015-04-24 – 2015-04-26
• [Presentation] Comparison between Clinical Scenario and Pathophysiology in Patients with Acute Decompensated Heart Failure in Japan (2015)
  • Author(s): Tomofumi Nakatsukasa, Masayoshi Yamamoto, Yoshihiro Seo, Tomoko Ishizu, Yoshie Harimura, Akiko Atsumi, Tomoko Machino, Akinori Sugano, Kimi Satou, Naoto Kawamatsu, Kazutaka Aonuma
  • Organizer: 第79回日本循環器学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2015-04-24 – 2015-04-26
• [Presentation] Worsening and Improving Renal Function among Ibaraki Cardiac Assessment Study Heart Failure Registry (2015)
  • Author(s): Naoto Kawamatsu,Yoshihiro Seo, Yoshie Harimura, Seika Sai, Kimi Sato, Akinori Sugano, Akiko Atsumi, Masayoshi Yamamoto, Tomoko Machino, Isao Nishi, Tomoko Ishizu, Kazutaka Aonuma
  • Organizer: 第79回日本循環器学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2015-04-24 – 2015-04-26
• [Presentation] Peripheral Coldness Associates with Left Ventricular Functional Reserve in Patients with Heart Failure with Preserved Ejection Fraction (2015)
  • Author(s): Daishi Nakagawa,Yoshie Harimura, Yoshihiro Seo, Tomoko Ishizu, Seika Sai, Kimi Sato, Daigo Hiraya, Akinori Sugano, Masayoshi Yamamoto, Ikuo Yoshida, Isao Nishi, Kenichi Obara, Kazutaka Aonuma
  • Organizer: 第79回日本循環器学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2015-04-24 – 2015-04-26
• [Presentation] Left Atrial Volume Index Predicts Frequent Hospitalization in Heart Failure with Preserved Ejection Fraction (2015)
  • Author(s): Yoshie Harimura, Yoshihiro Seo, Tomoko Ishizu, Daishi Nakagawa, Tomofumi Nakatsukasa, Seika Sai, Kimi Sato, Akinori Sugano, Daigo Hiraya, Masayoshi Yamamoto, Ikuo Yoshida, Isao Nishi, Kenichi Obara, Kazutaka Aonuma.
  • Organizer: 第79回日本循環器学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2015-04-24
• [Presentation] Left Ventricular Longitudinal Strain and Ventricular-Arterial Coupling in Heart Failure with Preserved Ejection Fraction; Results from ICAS-HF Registry (2014)
  • Author(s): Yoshie Harimura, Tomoko Ishizu, Naoto Kawamatsu, Kimi Sato, Akinori Sugano, Akiko Atsumi, Masayoshi Yamamoto, Tomoko Machino Ryo Kawamura, Hideki Nakajima, Noriko Iida, Isao Nishi, Yoshihiro Seo, Kazutaka Aonuma.
  • Organizer: Japanese Circulation Society
  • Place of Presentation: 東京国際フォーラム