Impact of novel causal gene mutation of familial hypercholesterolemia on its clinical features and prognosis

• Project/Area Number: 24591041
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Kanazawa University
• Principal Investigator: KAWASHIRI MASAAKI 金沢大学, 医学系, 准教授 (90345637)
• Co-Investigator(Kenkyū-buntansha): NOGUCHI Tohru 金沢大学, 医学系, 助教 (40456421)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 家族性高コレステロール血症 / PCSK9 / LDLコレステロール / LDL受容体 / 遺伝子多型

Outline of Final Research Achievements

A gain-of-function mutation of proprotein convertase subtilisin/kexin type9 (PCSK9) gene results in familial hypercholesterolemia (FH) through degeneration of hepatic low-density lipoprotein (LDL) receptor. PCSK9 E32K is considered as gain-of-function mutation because HepG2 cells transient transfected PCSK9 E32K plasmid secretes 139% of PCSK9 protein compared with wild type. We found 9 patient with double heterozygous of LDL receptor gene mutation and PCSK9 E32K mutation, and their LDL-cholesterol levels ranged from 195 to 581 mg/dL. The most severe case was accompanied with large tendon xanthoma resembling homozygous FH as well as extreme hypercholesterolemia. These findings suggest that some additive hereditary factors are needed to exacerbate clinical features of PCSK9 E32K carriers.

Research Products

• [Journal Article] Assessment of Coronary Atherosclerosis in Patients With Familial Hypercholesterolemia by Coronary Computed Tomography Angiography (2015)
  • Author(s): Tada H, Kawashiri MA, Okada H, Teramoto R, Konno T, Yoshimuta T, Sakata K, Nohara A, Inazu A, Kobayashi J, Mabuchi H, Yamagishi M, Hayashi K.
  • Journal Title: Am J Cardiol. Volume: 115 Issue: 6 Pages: 724-729
  • DOI: 10.1016/j.amjcard.2014.12.034
  • Peer Reviewed / Open Access
• [Journal Article] Right ventricular hypertrophy is associated with cardiovascular events in hypertrophic cardiomyopathy：Evidence from study with magnetic resonance. (2015)
  • Author(s): Nagata Y，Konno T，Fujino N，Hodatsu A，Nomura A，Hayashi K，Nakamura H，Kawashiri M，Yamagishi M.
  • Journal Title: Can J Cardiol. Volume: in press
  • Peer Reviewed
• [Journal Article] Autosomal Recessive Hypercholesterolemia: A Mild Phenotype of Familial Hypercholesterolemia: Insight from the Kinetic Study using Stable Isotope and Animal Studies (2015)
  • Author(s): Tada H, Kawashiri MA, Nohara A, Inazu A, Kobayashi J, Mabuchi H, Yamagishi M
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 22 Issue: 1 Pages: 1-9
  • DOI: 10.5551/jat.27227
  • NAID: 130004704376
  • ISSN: 1340-3478, 1880-3873
  • Peer Reviewed / Open Access
• [Journal Article] Exome sequencing in suspected monogenic dyslipidemias. (2015)
  • Author(s): Stitziel NO, Peloso GM, Abifadel M, Cefalu AB, Fouchier S, Motazacker MM, Tada H, Larach DB, Awan Z, Haller JF, Pullinger CR, Varret M, Noto D, Tarugi P, Kawashiri MA, Nohara A, Yamagishi M, Kathiresan S. et al.
  • Journal Title: Circ Cardiovasc Genet. Volume: 8 Issue: 2 Pages: 343-50
  • DOI: 10.1161/circgenetics.114.000776
  • Peer Reviewed / Open Access
• [Journal Article] Infantile Cases of Sitosterolaemia with Novel Mutations in the ABCG5 Gene: Extreme Hypercholesterolaemia is Exacerbated by Breastfeeding. (2015)
  • Author(s): Tada H, Kawashiri MA, Takata M, Matsunami K, Imamura A, Matsuyama M, Sawada H, Nunoi H, Konno T, Hayashi K, Nohara A, Inazu A, Kobayashi J, Mabuchi H, Yamagishi M.
  • Journal Title: JIMD Rep. Volume: in press Pages: 115-122
  • DOI: 10.1007/8904_2014_404
  • ISBN: 9783662471715, 9783662471722
  • Peer Reviewed
• [Journal Article] Impact of Enhanced Production of Endogenous Heme Oxygenase-1 by Pitavastatin on Survival and Functional Activities of Bone Marrow-derived Mesenchymal Stem Cells. (2015)
  • Author(s): Kawashiri MA, Nakanishi C, Tsubokawa T, Shimojima M, Yoshida S, Yoshimuta T, Konno T, Yamagishi M, Hayashi K.
  • Journal Title: J Cardiovasc Pharmacol. Volume: in press Issue: 6 Pages: 601-606
  • DOI: 10.1097/fjc.0000000000000231
  • Peer Reviewed / Open Access
• [Journal Article] Expansion of the Clinical Application of Optical Coherence Tomography to Percutaneous Coronary Intervention and Assessment of the Instability of Coronary Atherosclerosis (2015)
  • Author(s): Sakata K, Kawashiri MA, Hayashi K.
  • Journal Title: Circulation Journal Volume: 79 Issue: 3 Pages: 513-514
  • DOI: 10.1253/circj.CJ-15-0103
  • NAID: 130004927084
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access
• [Journal Article] Short- and long-term benefits of drug-eluting stents compared to bare metal stents even in treatment for large coronary arteries. (2015)
  • Author(s): Yoshida T, Sakata K, Nitta Y, Taguchi T, Kaku B, Katsuda S, Shimojima M, Gamou T, Nakahashi T, Konno T, Kawashiri MA, Yamagishi M, Hayashi K.
  • Journal Title: Heart Vessels. Volume: in press Issue: 5 Pages: 635-642
  • DOI: 10.1007/s00380-015-0655-3
  • Peer Reviewed
• [Journal Article] Extreme Contrast of Postprandial Remnant-Like Particles Formed in Abetalipoproteinemia and Homozygous Familial Hypobetalipoproteinemia. (2015)
  • Author(s): Kawashiri MA, Tada H, Hashimoto M, Taniyama M, Nakano T, Nakajima K, Inoue T, Mori M, Nakanishi C, Konno T, Hayashi K, Nohara A, Inazu A, Koizumi J, Ishihara H, Kobayashi J, Hirano T, Mabuchi H, Yamagishi M.
  • Journal Title: JIMD Rep. Volume: in press Pages: 85-94
  • DOI: 10.1007/8904_2015_415
  • ISBN: 9783662474525, 9783662474532
  • Peer Reviewed / Open Access
• [Journal Article] Whole exome sequencing combined with integrated variant annotation prediction identifies asymptomatic Tangier disease with compound heterozygous mutations in ABCA1 gene. (2015)
  • Author(s): Tada H, Kawashiri MA, Nohara A, Saito R, Tanaka Y, Nomura A, Konno T, Sakata K, Fujino N, Takamura T, Inazu A, Mabuchi H, Yamagishi M, Hayashi K.
  • Journal Title: Atherosclerosis. Volume: 240 Issue: 2 Pages: 324-9
  • DOI: 10.1016/j.atherosclerosis.2015.04.003
  • Peer Reviewed / Open Access
• [Journal Article] The evolution of non-diabetic hyperglycemia: a longitudinal study (2014)
  • Author(s): Oka R，Yagi K，Hayashi K，Kawashiri M，Yamagishi M，Yamada M，Fumisawa Y，Yamauchi K，Aizawa T.
  • Journal Title: Endocrine Journal Volume: 61 Issue: 1 Pages: 91-99
  • DOI: 10.1507/endocrj.EJ13-0359
  • NAID: 130004443934
  • ISSN: 0918-8959, 1348-4540
  • Peer Reviewed / Open Access
• [Journal Article] Vascular endothelial growth factor-bound stents: application of in situ capture technology of circulating endothelial progenitor cells in porcine coronary model. of (2014)
  • Author(s): Takabatake S, Hayashi K, Nakanishi C, Hao H, Sakata K, Kawashiri MA, Matsuda T, Yamagishi M.
  • Journal Title: J Interv Cardiol Volume: １ Issue: 1 Pages: 63-72
  • DOI: 10.1111/joic.12087
  • Peer Reviewed
• [Journal Article] Elevation of urinary liver-type fatty acid-binding protein as predicting factor for occurrence of contrast-induced acute kidney injury and its reduction by hemodiafiltration with blood suction from right atrium. (2014)
  • Author(s): Katoh H，Nozue T，Kimura Y，Nakata S，Iwaki T，Kawano M，Kawashiri M，Michishita I，Yamagishi M.
  • Journal Title: Heart Vessels Volume: 29 Issue: 2 Pages: 191-7
  • DOI: 10.1007/s00380-013-0347-9
  • Peer Reviewed
• [Journal Article] Elevated liver enzymes are related to progression to impaired glucose tolerance in Japanese men. (2014)
  • Author(s): Oka R，Aizawa T，Yagi K，Hayashi K，Kawashiri M，Yamagishi M.
  • Journal Title: Diabetic Med. Volume: 31 Issue: 5 Pages: 552-8
  • DOI: 10.1111/dme.12345
  • Peer Reviewed
• [Journal Article] Population impact of increased body mass index and attenuated beta-cell function on worsening of glucose metabolism in subjects with normal glucose tolerance：a pilot study. (2014)
  • Author(s): Yamauchi K，Oka R，Yagi K，Hayashi K，Kawashiri M，Yamagishi M，Shimbo T，Aizawa T.
  • Journal Title: Acta Diabetol. Volume: 51 Issue: 3 Pages: 441-5
  • DOI: 10.1007/s00592-013-0535-1
  • Peer Reviewed
• [Journal Article] Relationships between Alanine Aminotransferase (ALT), Visceral Adipose Tissue (AT) and Metabolic Risk Factors in a Middle-Aged Japanese Population (2014)
  • Author(s): Oka R，Yagi K，Nakanishi C，Konno T，Kawashiri M，Hayashi K，Nohara A，Inazu A，Yamagishi M.
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 21 Issue: 6 Pages: 582-592
  • DOI: 10.5551/jat.21790
  • NAID: 130004444749
  • ISSN: 1340-3478, 1880-3873
  • Peer Reviewed
• [Journal Article] High sensitivity of late gadolinium enhancement for predicting microscopic myocardial scarring in biopsied specimens in hypertrophic cardiomyopathy. (2014)
  • Author(s): Konno T，Hayashi K，Fujino N，Nagata Y，Hodatsu A，Masuta E，Sakata K，Nakamura H，Kawashiri M，Yamagishi M.
  • Journal Title: PLoS One. Volume: 9 Issue: 7 Pages: e101465-e101465
  • DOI: 10.1371/journal.pone.0101465
  • NAID: 120006460361
  • Peer Reviewed / Open Access
• [Journal Article] Clinical significance of measuring soluble LR11, a circulating marker of atherosclerosis and HbA1c in familial hypercholesterolemia. (2014)
  • Author(s): Nohara A，Kobayashi J，Kawashiri M，Tada H，Inazu A，Jiang M，Mabuchi H，Bujo H.
  • Journal Title: Clin Biochem. Volume: 47 Pages: 1326-8
  • Peer Reviewed
• [Journal Article] Genotypic and phenotypic features in homozygous familial hypercholesterolemia caused by proprotein convertase subtilisin/kexin type 9 (PCSK9) gain-of-function mutation (2014)
  • Author(s): Mabuchi H, Nohara A, Noguchi T, Kobayashi J, Kawashiri MA, Inoue T, Mori M, Tada H, Nakanishi C, Yagi K, Yamagishi M, Ueda K, Takegoshi T, Miyamoto S, Inazu A, Koizumi J; The Hokuriku FH Study Group
  • Journal Title: Atherosclerosis Volume: 236 Issue: 1 Pages: 54-61
  • DOI: 10.1016/j.atherosclerosis.2014.06.005
  • Peer Reviewed / Open Access
• [Journal Article] Guidelines for Diagnosis and Treatment of Patients With Vasospastic Angina (Coronary Spastic Angina) (JCS 2013) (2014)
  • Author(s): JCS Joint Working Group.
  • Journal Title: Circulation Journal Volume: 78 Issue: 11 Pages: 2779-2801
  • DOI: 10.1253/circj.CJ-66-0098
  • NAID: 130004926931
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed
• [Journal Article] Compound heterozygosity deteriorates phenotypes of hypertrophic cardiomyopathy with founder MYBPC3 mutation: evidence from patients and zebrafish models. (2014)
  • Author(s): Hodatsu A, Konno T, Hayashi K, Funada A, Fujita T, Nagata Y, Fujino N, Kawashiri MA, Yamagishi M.
  • Journal Title: Am J Physiol Heart Circ Physiol. Volume: 307 Issue: 11 Pages: 1594-604
  • DOI: 10.1152/ajpheart.00637.2013
  • Peer Reviewed
• [Journal Article] Impact of combined lipid lowering with blood pressure control on coronary plaque regression: rationale and design of MILLION study. (2014)
  • Author(s): Kawashiri MA, Sakata K, Gamou T, Kanaya H, Miwa K, Ueda K, Higashikata T, Mizuno S, Michishita I, Namura M, Nitta Y, Katsuda S, Okeie K, Hirase H, Tada H, Uchiyama K, Konno T, Hayashi K, Ino H, Nagase K, Terashima M, Yamagishi M.
  • Journal Title: Heart Vessels. Volume: in press Issue: 5 Pages: 580-586
  • DOI: 10.1007/s00380-014-0522-7
  • Peer Reviewed
• [Journal Article] Fragmented QRS Predicts Heart Failure Progression in Patients With Hypertrophic Cardiomyopathy (2014)
  • Author(s): Nomura A, Konno T, Fujita T, Tanaka Y, Nagata Y, Tsuda T, Hodatsu A, Sakata K, Nakamura H, Kawashiri MA, Fujino N, Yamagishi M, Hayashi K.
  • Journal Title: Circulation Journal Volume: 79 Issue: 1 Pages: 136-143
  • DOI: 10.1253/circj.CJ-14-0822
  • NAID: 130004704014
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access
• [Journal Article] Increased extent of myocardial fibrosis in genotyped hypertrophic cardiomyopathy with ventricular tachyarrhythmias. (2014)
  • Author(s): Fujita T, Konno T, Yokawa J, Masuta E, Nagata Y, Fujino N, Funada A, Hodatsu A, Kawashiri MA, Yamagishi M, Hayashi K.
  • Journal Title: J Cardiol. Volume: in press Issue: 1 Pages: 63-68
  • DOI: 10.1016/j.jjcc.2014.10.002
  • Peer Reviewed / Open Access
• [Journal Article] Current perspectives in genetic cardiovascular disorders: from basic to clinical aspects (2014)
  • Author(s): Kawashiri MA, Hayashi K, Konno T, Fujino N, Ino H, Yamagishi M.
  • Journal Title: Heart Vessels Volume: 29 Issue: 2 Pages: 129-41
  • DOI: 10.1007/s00380-013-0391-5
  • Peer Reviewed
• [Journal Article] Erdheim-Chester disease involving the brain and the heart. (2014)
  • Author(s): Kawashiri MA, Ishibashi-Ueda H, Funada A, Yoshimuta T, Konno T, Hayashi K, Yamagishi M.
  • Journal Title: J Am Coll Cardiol. Volume: 25 Issue: 11 Pages: 1121-1121
  • DOI: 10.1016/j.jacc.2013.11.047
  • Peer Reviewed
• [Journal Article] Impact of fluoroscopically-visible fluttering flap on clinical diagnosis of acute aortic dissection. (2014)
  • Author(s): Tanaka Y, Sakata K, Kawashiri MA, Nakanishi C, Konno T, Yoshimuta T, Hayashi K, Tomita S, Watanabe G, Yamagishi M.
  • Journal Title: J Am Coll Cardiol. Volume: ６３ Issue: 14 Pages: e31-e31
  • DOI: 10.1016/j.jacc.2013.10.094
  • Peer Reviewed
• [Journal Article] Can Next-Generation Sequencing Replace Sanger Sequencing for Screening Genetic Variants? (2014)
  • Author(s): Kawashiri MA, Nomura A, Konno T, Hayashi K.
  • Journal Title: Circulation Journal Volume: 78 Issue: 12 Pages: 2845-2847
  • DOI: 10.1253/circj.CJ-14-1144
  • NAID: 130004704007
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed
• [Journal Article] Impact of lesion morphology and associated procedures for left main coronary stenting on angiographic outcome after intervention: sub-analysis of Heart Research Group of Kanazawa, HERZ, Study. (2013)
  • Author(s): Kawashiri MA, Sakata K, Uchiyama K, Konno T, Namura M, Mizuno S, Tatami R, Kanaya H, Nitta Y, Michishita I, Hirase H, Ueda K, Aoyama T, Okeie K, Haraki T, Mori K, Araki T, Minamoto M, Oiwake H, Ino H, Hayashi K, Yamagishi M.
  • Journal Title: Cardiovasc Interv Ther. Volume: 29 Issue: 2 Pages: 119-22
  • DOI: 10.1007/s12928-013-0222-8
  • NAID: 40020048942
  • Peer Reviewed
• [Journal Article] Impact of intensive lipid lowering on lipid profiles over time and tolerability in stable coronary artery disease: insights from a subanalysis of the coronary atherosclerosis study measuring effects of rosuvastatin using intravascular ultrasound in Japanese subjects (COSMOS). (2013)
  • Author(s): Kawashiri MA, Yamagishi M, Sakamoto T, Takayama T, Hiro T, Daida H, Hirayama A, Saito S, Yamaguchi T, Matsuzaki M; COSMOS Investigators.
  • Journal Title: Cardiovasc Ther. Volume: 31 Issue: 6 Pages: 335-43
  • DOI: 10.1111/1755-5922.12027
  • Peer Reviewed
• [Journal Article] Comparison of effects of pitavastatin versus pravastatin on serum proprotein convertase subtilisin/kexin type 9 levels in statin-naive patients with coronary artery disease. (2013)
  • Author(s): Nozue T, Hattori H, Ishihara M, Iwasaki T, Hirano T, Kawashiri MA, Yamagishi M, Michishita I.
  • Journal Title: Am J Cardiol. Volume: 111 Issue: 10 Pages: 1415-9
  • DOI: 10.1016/j.amjcard.2013.01.289
  • Peer Reviewed
• [Journal Article] Sarcomere Gene Mutations Are Associated With Increased Cardiovascular Events in Left Ventricular Hypertrophy : Results From Multicenter Registration in Japan. (2013)
  • Author(s): Fujita T, Komuro I (18人中13番目）
  • Journal Title: JACC Heart Fail Volume: 6 Issue: 6 Pages: 459-466
  • DOI: 10.1016/j.jchf.2013.08.007
  • Peer Reviewed
• [Journal Article] Rapid changes in plaque composition and morphology after intensive lipid lowering therapy: study with serial coronary CT angiography. (2012)
  • Author(s): Shimojima M, Kawashiri MA, Nitta Y, Yoshida T, Katsuda S, Kaku B, Taguchi T, Hasegawa A, Konno T, Hayashi K, Yamagishi M.
  • Journal Title: Am J Cardiovasc Dis. Volume: 2 Pages: 84-8
  • NAID: 120006334912
  • Peer Reviewed
• [Journal Article] Impact of visceral adipose tissue and subcutaneous adipose tissue on insulin resistance in middle-aged Japanese. (2012)
  • Author(s): Oka R, Yagi K, Sakurai M, Nakamura K, Nagasawa SY, Miyamoto S, Nohara A, Kawashiri MA, Hayashi K, Takeda Y, Yamagishi M.
  • Journal Title: J Atheroscler Thromb. Volume: 19 Pages: 814-22
  • NAID: 130004845409
  • Peer Reviewed
• [Journal Article] Expression and Function of Ephrin-B1 and Its Cognate Receptor EphB2 in Human Abdominal Aortic Aneurysm. (2012)
  • Author(s): Sakamoto A, Kawashiri M, Ishibashi-Ueda H, Sugamoto Y, Yoshimuta T, Higashikata T, Ogino H, Tada H, Konno T, Hayashi K, Yamagishi M.
  • Journal Title: Int J Vasc Med. Volume: 2012 Pages: 127149-127149
  • DOI: 10.1155/2012/127149
  • NAID: 120006332061
  • Peer Reviewed
• [Journal Article] A novel type of familial hypercholesterolemia : double heterozygous mutations in LDL receptor and LDL receptor adaptor protein 1 gene (2011)
  • Author(s): Tada H, Kawashiri MA, Ohtani R, Noguchi T, Nakanishi C, Konno T, Hayashi K, Nohara A, Inazu A, Kobayashi J, Mabuchi H, Yamagishi M
  • Journal Title: Atherosclerosis Volume: 219 Issue: 2 Pages: 663-6
  • DOI: 10.1016/j.atherosclerosis.2011.08.004
  • NAID: 120003368152
  • Peer Reviewed
• [Presentation] Vascular Complications of Japanese FH Patients (2015)
  • Author(s): Kawashiri MA
  • Organizer: The Satellite Symposium of the ISA 2015 in Tokyo
  • Place of Presentation: 伊藤国際学術研究センター（東京都）
  • Year and Date: 2015-05-21
  • Invited
• [Presentation] Impact of combined lipid lowering with calcium channel antagonist based blood pressure control on coronary plaque regression: MILLION Study. (2015)
  • Author(s): Kawashiri MA，Sakata K，Gamou T，Kanaya H，Miwa K，Ueda K，Higashikata T，Mizuno S，Michishita I，Namura M，Nitta Y，Katsuda S，Okeie K，Hirase H，Tada H，Konno T，Hayashi K，Ino H，Nagase K，Terashima M，Yamagishi M.
  • Organizer: The Society for Cardiovascular Angiography and Interventions Foundation 2015（招待講演）
  • Place of Presentation: Hilton San Diego Bayfront（米国）
  • Year and Date: 2015-05-06 – 2015-05-09
  • Invited
• [Presentation] ランチョンセミナー 冠動脈プラーク形成予防のための脂質管理の重要性 (2014)
  • Author(s): 川尻剛照
  • Organizer: 第46回日本動脈硬化学会学術集会
  • Place of Presentation: 京王プラザホテル（東京都）
  • Year and Date: 2014-07-10 – 2014-07-11
  • Invited
• [Presentation] イブニングセミナー 冠動脈疾患予防のための脂質管理 (2014)
  • Author(s): 川尻剛照
  • Organizer: 第25回日本心エコー図学会学術集会
  • Place of Presentation: 石川県立音楽堂（石川県）
  • Year and Date: 2014-04-17 – 2014-04-19
  • Invited
• [Presentation] シンポジウム 家族性高コレステロール血症に対するLDLアフェレシス治療 (2014)
  • Author(s): 川尻剛照
  • Organizer: 日本医工学治療学会第30回学術大会
  • Place of Presentation: ウインクあいち（愛知県）
  • Invited
• [Presentation] Impact of PCSK9 E32K mutation on clinical phenotype of familial hypercholesterolemia (2014)
  • Author(s): Masaaki Kawashiri, Kosei Morishita, Takeshi Inoue, Chiaki Nakanishi, Mika Mori, Atsushi Nohara, Akihiro Inazu, Junji Kobayashi, Hiroshi Mabuchi, Masakazu Yamagishi
  • Organizer: 第78回日本循環器学会総会・学術集会
  • Place of Presentation: 東京国際フォーラム（東京等）
• [Presentation] シンポジウムAntisense inhibition of apolipoprotein B syntehsis: A promising therapeutic option for homozygous familial hypercholesterolemia. (2013)
  • Author(s): Masaaki Kawashiri, Takeshi Inoue, Hayato Tada, Chiaki Nakanishi, Mika Mori, Atsushi Nohara, Akihiro Inazu, Hiroshi Mabuchi H, Masakazu Yamagishi
  • Organizer: 第45回日本動脈硬化学会総会・学術集会
  • Place of Presentation: 京王プラザホテル（東京都）
  • Invited
• [Presentation] シンポジウム 家族性高コレステロール血症に対するLDLアフェレシス治療 (2013)
  • Author(s): 川尻剛照、野原淳、馬渕宏、山岸正和
  • Organizer: 第34回日本アフェレシス学会学術大会
  • Place of Presentation: 軽井沢プリンスホテルウエスト（群馬県）
  • Invited
• [Presentation] PCSK9: A Marker of Responsiveness to Statin and Atheerosclerosis (2013)
  • Author(s): Masa-aki Kawashiri, Tohru Noguchi, Mutsuko Takata, Atsushi Nohara, Akihiro Inazu, Hiroaki Hattori, Hiroshi Mabuchi, Masakazu Yamagishi
  • Organizer: 第77回日本循環器学会学術集会
  • Place of Presentation: パシフィコ横浜（神奈川県）
  • Invited
• [Presentation] Immpact of Rosuvastatin on Lipid Profiles Over Time in Stable Coronary Artery Disease: Insights From Subanalysis of COSMOS Study (2013)
  • Author(s): Masa-aki Kawashiri, Masakazu Yamagishi, Tomohiro Sakamoto, Tadateru Takayama, Takafumi Hiro, Hiroyuki Daida, Atsushi Hirayama, Satoshi Saito, Tetsu Yamaguchi, Masunori Matsuzaki
  • Organizer: 第77回日本循環器学会学術集会
  • Place of Presentation: パシフィコ横浜（神奈川県）
• [Presentation] Extreme Contrast of Atherosclerosis in Coronary and Carotid Artery in Patients with Lipoprotein-lipase Deficiency due to Different Gene Mutation (2012)
  • Author(s): 川尻剛照、小林淳二、多田隼人、野口徹、野原淳、稲津明広、馬渕宏、山岸正和
  • Organizer: 第44回日本動脈硬化学会総会・学術集会
  • Place of Presentation: ヒルトン福岡シーホーク（福岡県）
• [Presentation] マルチリスク管理：その効果と展望 (2012)
  • Author(s): 川尻剛照、野原淳、今野哲雄、林研至、馬渕宏、山岸正和
  • Organizer: 第60回日本心臓病学会学術集会
  • Place of Presentation: ホテル日航金沢他（石川県）
  • Invited
• [Presentation] 長期予後からみたPCI後のリスク管理 (2012)
  • Author(s): 川尻剛照
  • Organizer: 第28回CVIT東海北陸地方会
  • Place of Presentation: 金沢歌舞伎座（石川県）
  • Invited
• [Presentation] Statin Therapy Improves Fractional Catabolic Rate of LDL without Affecting Impaired VLDL and VLDL Remnant Catabolism in Homozygous FH Patient Due to PCSK9 Gene Mutation: Evidence from Kinetic Study with Stable Isotope (2012)
  • Author(s): Masa-aki Kawashiri, Katsunori Ikewaki, Hayato Tada, Tohru Noguchi, Atsushi Nohara, Akihiro Inazu, Junji Kobayashi, Hiroshi Mabuchi, Masakazu Yamagishi
  • Organizer: The 85th American Heart Association 2012 Scientific Sessions
  • Place of Presentation: Los Angeles Convention Center (USA)
• [Book] 血管医学 PCSK9阻害薬 (2015)
  • Author(s): 川尻剛照
  • Publisher: メディカルレビュー社
• [Book] Heart View PCSK9をターゲットとした新しい治療を識る (2015)
  • Author(s): 川尻剛照
  • Publisher: メジカルビュー社
• [Book] 日本内科学会雑誌 発熱と筋力低下 ～症候の組み合わせから診断を考える～ (2014)
  • Author(s): 松村正巳，森三佳，島田敏實，川尻剛照，山岸正和
  • Total Pages: 1046
  • Publisher: 日本内科学会
• [Book] Vascular Medicine スタチンの薬剤感受性遺伝子を探る (2014)
  • Author(s): 川尻剛照
  • Total Pages: 168
  • Publisher: 先端医学社
• [Book] 最新医学 コレステロール低下療法の現状と展望 (2014)
  • Author(s): 川尻剛照
  • Total Pages: 3374
  • Publisher: 最新医学社
• [Book] 心臓 家族性高コレステロール血症をめぐる新展開 (2013)
  • Author(s): 川尻剛照、多田隼人、山岸正和
  • Total Pages: 109
  • Publisher: 日本医学出版
• [Book] medicina 最新の動脈硬化診療 どう診断し、どう治療するか？ (2013)
  • Author(s): 川尻剛照、多田隼人、山岸正和
  • Total Pages: 198
  • Publisher: 医学書院
• [Book] 循環器専門医 PCSK9：動脈硬化予防の次なるターゲット (2013)
  • Author(s): 川尻剛照、山岸正和
  • Total Pages: 206
  • Publisher: 南光堂
• [Book] 循環器内科 特集「インスリン抵抗性と心血管疾患」心血管イベント予防・スタチン (2012)
  • Author(s): 川尻剛照、多田隼人、山岸正和
  • Total Pages: 9
  • Publisher: 科学評論社
• [Book] 診療ガイドラインUp-to-Date 2012-2013 心筋梗塞 (2012)
  • Author(s): 川尻剛照、今野哲雄、林研至、山岸正和
  • Total Pages: 9
  • Publisher: メディカルビュー社