Efficacy and Safety of Traditional Japanese Medicine (Kampo) for Chronic Heart Failure Patients with Cardiorenal Syndrome

• Project/Area Number: 24591042
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Shinshu University
• Principal Investigator: IZAWA Atsushi 信州大学, 学術研究院医学系(医学部附属病院), 講師 (50464095)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 慢性心不全 / 慢性腎臓病 / 心腎関連 / 東洋医学 / 心腎連関

Outline of Final Research Achievements

We aimed to explore efficacy and safety of Boiogito treatment, in combination with conventional medical therapy for chronic heart failure patients with cardiorenal syndrome (CRS). Boiogito was increased up to 7.5 g/day, and patients were evaluated at 3.5 and 9.4 months. Boiogito treatment significantly increased mean estimated glomerular filtration rate and decreased mean levels of blood urea nitrogen, serum creatinine and brain natriuretic peptide. Efficacy and safety of Boiogito treatment for both renal function and heart failure status were demonstrated in patients with CRS.

Research Products

• [Journal Article] Importance of fatty acid compositions in patients with peripheral arterial disease (2015)
  • Author(s): Gautam M, Izawa A, Shiba Y, Motoki H, Takeuchi T, Okada A, Tomita T, Miyashita Y, Koyama J, Ikeda U.
  • Journal Title: PLoS One Volume: 9 Issue: 9 Pages: e107003-e107003
  • DOI: 10.1371/journal.pone.0107003
  • NAID: 120007100719
  • Peer Reviewed / Open Access
• [Journal Article] The traditional japanese medicine (Kampo) boiogito has a dual benefit in cardiorenal syndrome: A pilot observational study. (2014)
  • Author(s): Gautam M, Izawa A, Saigusa T, Yamasaki S, Motoki H, Tomita T, Miyashita Y, Koyama J, Hongo M, Ikeda U.
  • Journal Title: Shinshu Med J Volume: 62(2) Pages: 89-97
  • NAID: 130004551929
  • Peer Reviewed
• [Journal Article] Significant pericardial involvement of immunoglobulin g4-related disease. (2014)
  • Author(s): Morita T, Izawa A, Hamano H, Asano N, Kozuka A, Moteki H, Fuke M, Koyama J, Amano J, Ikeda U.
  • Journal Title: Ann Thorac Surg Volume: 98(2) Issue: 2 Pages: e47-e49
  • DOI: 10.1016/j.athoracsur.2014.04.069
  • Peer Reviewed
• [Journal Article] Low levels of high-density lipoprotein cholesterol predict the presence of coronary artery disease in patients with aortic aneurysms (2014)
  • Author(s): Saigusa T, Izawa A, Miura T, Ebisawa S, Shiba Y, Miyashita Y, Tomita T, Koyama J, Fukui D, Takano T, Amano J, Ikeda U
  • Journal Title: Angiology Volume: 65 Issue: 8 Pages: 710-715
  • DOI: 10.1177/0003319713502391
  • Peer Reviewed / Open Access
• [Journal Article] Infective endocarditis associated with mitral valve prolapse in a patient with klinefelter syndrome. (2014)
  • Author(s): Ueki Y, Izawa A, Ebisawa S, Motoki H, Miyashita Y, Tomita T, Koyama J, Takano T, Amano J, Ikeda U.
  • Journal Title: Intern Med Volume: 53(9) Pages: 969-972
  • NAID: 130004902971
  • Peer Reviewed
• [Journal Article] Impact of azelnidipine and amlodipine on left ventricular mass and longitudinal function in hypertensive patients with left ventricular hypertrophy. (2014)
  • Author(s): Motoki H, Koyama J, Izawa A, Tomita T, Miyashita Y, Takahashi M, Ikeda U.
  • Journal Title: Echocardiography Volume: 31(10) Issue: 10 Pages: 1230-1238
  • DOI: 10.1111/echo.12548
  • Peer Reviewed
• [Journal Article] Impact of endovascular therapy on oxidative stress in patients with peripheral artery disease. (2014)
  • Author(s): Ebisawa S, Kashima Y, Miyashita Y, Yamazaki S, Abe N, Saigusa T, Miura T, Motoki H, Izawa A, Ikeda U.
  • Journal Title: Circ J Volume: 78(6) Pages: 1445-1450
  • NAID: 130003391109
  • Peer Reviewed
• [Journal Article] Diagnostic value of peripheral fractional flow reserve in isolated iliac artery stenosis : A comparison with the post-exercise ankle-brachial index (2014)
  • Author(s): Hioki H, Miyashita Y, Miura T, Ebisawa S, Motoki H, Izawa A, Tomita T, Koyama J, Ikeda U
  • Journal Title: J Endovasc Ther Volume: 21 Issue: 5 Pages: 625-632
  • DOI: 10.1583/14-4734mr.1
  • Peer Reviewed / Open Access
• [Journal Article] Presence of diastolic dysfunction in patients with peripheral artery disease (2013)
  • Author(s): Yamasaki S, Izawa A, Shiba Y, Tomita T, Miyashita Y, Koyama J, Ikeda U.
  • Journal Title: Angiology Volume: 64(7) Issue: 7 Pages: 540-543
  • DOI: 10.1177/0003319713476135
  • Peer Reviewed
• [Journal Article] Crucial role of hyaluronan in neointimal formation after vascular injury. (2013)
  • Author(s): Kashima Y, Takahashi M, Shiba Y, Itano N, Izawa A, Koyama J, Nakayama J, Taniguchi S, Kimata K, Ikeda U.
  • Journal Title: PLoS One Volume: 8 Issue: 3 Pages: e58760-e58760
  • DOI: 10.1371/journal.pone.0058760
  • Peer Reviewed
• [Journal Article] Serum High-density Lipoprotein Cholesterol Level and Lifestyle Habits among Japanese Junior High School Students. (2013)
  • Author(s): Hongo M, Hidaka H, Sakaguchi S, Nakanishi K, Terasawa F, Ichikawa M, Hirota N, Tsuruta G, Tanaka N, Izawa A, Yazaki Y, Ikeda U, Koike K, on behalf of the Investigators of the Study Project on Prevention of Metabolic Syndrome among Children, Adolescents, and Young Adults in Shinshu.
  • Journal Title: Shinshu Med J Volume: 61（4） Pages: 205-215
  • NAID: 130004551901
  • Peer Reviewed
• [Journal Article] Torsion analysis in the early detection of anthracycline-mediated cardiomyopathy. (2012)
  • Author(s): Motoki H, Koyama J, Nakazawa H, Aizawa K, Kasai H, Izawa A, Tomita T, Miyashita Y, Kumazaki S, Takahashi M, Ikeda U.
  • Journal Title: Eur Heart J Cardiovasc Imaging Volume: 13 Issue: 1 Pages: 95-103
  • DOI: 10.1093/ejechocard/jer172
  • Peer Reviewed
• [Journal Article] Human ES-cell-derived cardiomyocytes electrically couple and suppress arrhythmias in injured hearts. (2012)
  • Author(s): Shiba Y, Fernandes S, Zhu WZ, Filice D, Muskheli V, Kim J, Palpant NJ, Gantz J, Moyes KW, Reinecke H, Van Biber B, Dardas T, Mignone JL, Izawa A, Hanna R, Viswanathan M, Gold JD, 他5名
  • Journal Title: Nature Volume: 489(7415) Issue: 7415 Pages: 322-325
  • DOI: 10.1038/nature11317
  • Peer Reviewed
• [Journal Article] Immunoadsorption therapy reduces oxidative stress in patients with dilated cardiomyopathy. (2012)
  • Author(s): Kasai H, Kashima Y, Izawa A, Tomita T, Miyashita Y, Koyama J, Takahashi M, Yoshio T, Yazaki Y, Higuchi M, Ikeda U
  • Journal Title: World Journal of Cardiovascular Diseases Volume: 2 Pages: 305-312
  • Peer Reviewed
• [Presentation] Clinical impact of initial reduction of low-density lipoprotein cholesterol level on long-term outcome of acute myocardial infarction in the statin era. (2014)
  • Author(s): Miura T, Izawa A, Motoki H, Miyashita Y, Kashima Y, Tomita T, Koyama J, Ikeda U.
  • Organizer: 米国心臓協会
  • Place of Presentation: シカゴ
  • Year and Date: 2014-11-15 – 2014-11-19
• [Presentation] A comparison of pravastatin and atorvastatin in patients with reduced left ventricular ejection fraction after acute myocardial infarction. (2014)
  • Author(s): 伊澤 淳、嘉嶋勇一郎、三浦 崇、海老澤聡一朗、北林 浩、山本博昭、櫻井俊平、宮下裕介、小山 潤、池田宇一
  • Organizer: 日本心不全学会学術集会
  • Place of Presentation: 大阪国際会議場（大阪）
  • Year and Date: 2014-10-10 – 2014-10-12
• [Presentation] 急性冠症候群(ACS)を対象として長野県で実施された3つの大規模臨床研究で得られたこと (2014)
  • Author(s): 伊澤 淳、三浦 崇、海老澤聡一朗、嘉嶋勇一郎、岡田綾子、富田 威、宮下裕介、小山 潤、池田宇一、大和眞史、SHINANO ACS, ALPS-AMI study, Shinano Registry参加施設一同
  • Organizer: 長野県医学会
  • Place of Presentation: ホテルメトロポリタン長野（長野）
  • Year and Date: 2014-07-13
• [Presentation] Regulatory T cell is associated with lipid plaque in coronary artery using intravascular ultrasound. (2013)
  • Author(s): Saigusa T, Kashima Y, Izawa A, Hioki H, Karube K, Yaguchi T, Abe N, Miura T, Ebisawa S, Tomita T, Miyashita Y, Koyama J, Ikeda U.
  • Organizer: 米国心臓学会議
  • Place of Presentation: サンフランシスコ
• [Presentation] Important Role of Fatty Acid Composition and Cardiovascular Risk Factors in Patients with Peripheral Arterial Disease. (2013)
  • Author(s): Milan Gautam, Izawa A, Shiba Y, Aizawa K, Koshikawa M, Kasai H, Tomita T, Miyashita Y, Koyama J, Ikeda U.
  • Organizer: 日本循環器学会学術集会
  • Place of Presentation: 横浜
• [Presentation] Assessment of lipophilic vs. hydrophilic statin therapy in Acute Myocardial Infarction(The ALPS-AMI study). (2013)
  • Author(s): Izawa A, Kashima Y, Ebisawa S, Miura T, Saigusa T, Shiba Y, Miyashita Y, Tomita T, Koyama J, Ikeda U.
  • Organizer: 欧州心臓学会議
  • Place of Presentation: アムステルダム
• [Presentation] Predictors of long-term outcomes in patients with medical treatment for acute aortic dissection. (2013)
  • Author(s): Izawa A, Hirota S, Yamaka K, Takeuchi T, Okada A, Shiba Y, Tomita T, Miyashita Y, Koyama J, Ikeda U.
  • Organizer: 欧州心臓学会議
  • Place of Presentation: アムステルダム
• [Presentation] Important Role of Fatty Acid Composition and Cardiovascular Risk Factors in Patients with Peripheral Arterial Disease. (2013)
  • Author(s): Milan Gautam, Izawa A, Shiba Y, Aizawa K, Koshikawa M, Kasai H, Tomita T, Miyashita Y, Koyama J, Ikeda U
  • Organizer: 第77回日本循環器学会学術集会
  • Place of Presentation: 横浜
• [Presentation] Regulatory T cell is Associated with Lipid Plaque in Coronary Artery Using Intravascular Ultrasound. (2013)
  • Author(s): Saigusa T, Kashima Y, Izawa A, Hioki H, Karube K, Yaguchi T, Abe N, Miura T, Ebisawa S, Tomita T, Miyashita Y, Koyama J, Ikeda U
  • Organizer: 第77回日本循環器学会学術集会
  • Place of Presentation: 横浜
• [Presentation] A Comparison of Echocardiographic Features of Hereditary Transthyretin Amyloidosis and Senile Systemic Amyloidosis. (2013)
  • Author(s): Minamisawa M, Koyama J, Kozuka A, Aizawa K, Kasai H, Izawa A, Tomita T, Miyashita Y, Ikeda U
  • Organizer: 第77回日本循環器学会学術集会
  • Place of Presentation: 横浜
• [Presentation] Development of spontaneous myocarditis in Nuclear Factor kappa B(NFκB)p50-deficient mice:the emerging role of NFκB p65 in its pathogenesis. (2012)
  • Author(s): Gautam Milan, Izawa A, Shiba Y, Kashima Y, Koyama J, Hongo M, Sano K, Hayashi T, Ichikawa M, Ikeda U
  • Organizer: 米国心臓病学会議
  • Place of Presentation: ロサンゼルス