Development of the comprehensive strategy with using
| Project/Area Number |
24591044
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Gifu University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | nicorandil / coronary artery disease / randomized trial / cystatin C / contrast / ischemic preconditioning / nephropathy / coronary intervention / 造影剤腎症 / K-ATPチャネルオープナー / 冠動脈形成術 / 腎虚血傷害 / 造影剤腎症ウサギモデル / 腎保護作用 / 動脈硬化ウサギモデル / 主要心腎血管イベント / 無作為比較試験 |
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| Outline of Final Research Achievements |
We conducted a prospective randomized trial to assess the protective effect of continuous intravenous infusion of nicorandil against contrast-induced nephropathy (CIN) in patients with poor renal function. We randomly assigned patients who would subsequently undergo elective percutaneous coronary intervention (PCI) and who had a high serum cystatin C level to a saline group or a nicorandil group. The average percent increases in serum creatinine and cystatin C following PCI were significantly smaller in the nicorandil group than the saline group, and the average percent decline in the estimated glomerular filtration rate was smaller in the nicorandil group.Correspondingly, the incidence of CIN was dramatically lower in the nicorandil group than the saline group.
Univariate regression analysis revealed nicorandil treatment to be the only significant predictor of CIN development. Nicorandil strongly prevents CIN in patients with poor renal function undergoing PCI.
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Report
(4 results)
Research Products
(6 results)
