| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Outline of Final Research Achievements |
We conducted a prospective randomized trial to assess the protective effect of continuous intravenous infusion of nicorandil against contrast-induced nephropathy (CIN) in patients with poor renal function. We randomly assigned patients who would subsequently undergo elective percutaneous coronary intervention (PCI) and who had a high serum cystatin C level to a saline group or a nicorandil group. The average percent increases in serum creatinine and cystatin C following PCI were significantly smaller in the nicorandil group than the saline group, and the average percent decline in the estimated glomerular filtration rate was smaller in the nicorandil group.Correspondingly, the incidence of CIN was dramatically lower in the nicorandil group than the saline group.
Univariate regression analysis revealed nicorandil treatment to be the only significant predictor of CIN development. Nicorandil strongly prevents CIN in patients with poor renal function undergoing PCI.
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