Impact of myocardial gene expression and exercise capacity in cardiomyopathy

• Project/Area Number: 24591046
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Nagoya University
• Principal Investigator: Hirashiki Akihiro 名古屋大学, 医学(系)研究科(研究院), 寄附講座助教 (10418741)
• Co-Investigator(Kenkyū-buntansha): TAKESHITA KYOSUKE 名古屋大学, 医学部附属病院, 講師 (70444403) ; BANDO YASUKO 名古屋大学, 医学部附属病院, 講師 (60452190) ; MUROHARA TOYOAKI 名古屋大学, 大学院医学系研究科, 教授 (90299503)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 運動耐容能 / 心肺運動負荷試験 / 拡張型心筋症 / 心不全 / 肺高血圧症 / 心筋症

Outline of Final Research Achievements

The presence of pulmonary hypertension (PH) was independently associated with an increased incidence of cardiac death in ambulatory patients with dilated cardiomyopathy (DCM). %PPeak VO2 was strongly associated with the presence of PH in patients with DCM. Taken together, these findings indicate that CPX variables could be important for diagnosing PH in patients with DCM.
In patients with DCM, LGE moderately correlated with collagen volume fraction (CVF). CVF also correlated with impaired left ventricular (LV) relaxation and the down-regulation of mitochondrialenzyme gene expression. Positive late gadolinium enhancement (LGE) on cardiac cardiac magnetic resonance was more strongly associated with adverse LV remodeling than was CVF determined by endomyocardial biopsy (EMB). Positive LGE may provide useful information, not only about myocardial fibrosis, but also about myocardial mitochondrial dysfunction.

Research Products

• [Journal Article] Effects of bosentan on peripheral endothelial function in patients with pulmonary arterial hypertension or chronic thromboembolic pulmonary hypertension (2016)
  • Author(s): Hirashiki A, Adachi S, Nakano Y, Kamimura Y, Shimokata S, Takeshita K, Murohara T, and Kondo T.
  • Journal Title: Pulm Circ Volume: 印刷中
  • Open Access / Acknowledgement Compliant
• [Journal Article] Cardiopulmonary Exercise Testing as a Tool for Diagnosing Pulmonary Hypertension in Patients with Dilated Cardiomyopathy (2016)
  • Author(s): Hirashiki A, Kondo T, Okumura T, Kamimura Y, Nakano Y, Fukaya K, Sawamura A, Morimoto R, Adachi S, Takeshita K, Murohara T.
  • Journal Title: Annals of Noninvasive Electrocardiology Volume: - Pages: 263-271
  • DOI: 10.1111/anec.12308
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The Roles of Classic and Current Prognostic Factors in Pulmonary Hypertension Due to Left Heart Disease (2016)
  • Author(s): Hirashiki A, Kondo T, Murohara T.
  • Journal Title: Circ J Volume: 80 Issue: 1 Pages: 72-3
  • DOI: 10.1253/circj.CJ-15-1241
  • NAID: 130005117013
  • Peer Reviewed / Open Access
• [Journal Article] Impact of preoperative regular physical activity on postoperative course after open abdominal aortic aneurysm surgery (2016)
  • Author(s): 49.Hayashi K, Hirashiki A, Kodama A, Kobayashi K, Yasukawa Y, Shimizu M, Kondo T, Komori K, Murohara T
  • Journal Title: Heart Vessels Volume: 31 Pages: 578-583
  • DOI: 10.1007/s00380-015-0644-6
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Epigenome-wide association study suggests that SNPs in the promoter region of RETN influence plasma resistin level via effects on DNA methylation at neighboring sites. (2015)
  • Author(s): M. Nakatochi, S. Ichihara, K. Yamamoto, K. Ohnaka, Y. Kato, S. Yokota, A. Hirashiki, K. Naruse, H, Asano, H. Izawa, T. Matsubara, and M. Yokota
  • Journal Title: Diabetologia Volume: 58 Pages: 2781-2190
  • DOI: 10.1007/s00125-015-3763-9
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Clinical Characteristics and Long-Term Outcomes of Hypertrophic Cardiomyopathy (2015)
  • Author(s): Yoshinaga M, Yoshikawa D, Ishii H, Hirashiki A, Okumura T, Kubota A, Sakai S, Harada K, Somura F, Mizuno T, Fujiwara W, Yokoi H, Hayashi M, Ishii J, Ozaki Y, Murohara T, Yoshida Y, Amano T, Izawa H.
  • Journal Title: Int. Heart J. Volume: 56 Issue: 4 Pages: 415-20
  • DOI: 10.1536/ihj.14-418
  • NAID: 130005087575
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Assessment of respiratory disturbance index determined with a non-restrictive monitor and of autonomic nervous system parameters in heart failure patients: A pilot study (2015)
  • Author(s): Shimazu S, Hirashiki A, Kamimura Y, Nakano Y, Adachi S, Kondo T, Murohara T.
  • Journal Title: .J Cardiol. Volume: 66 Pages: 218-223
  • DOI: 10.1016/j.jjcc.2014.12.018
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Impact of preoperative regular physical activity on postoperative course after open abdominal aortic aneurysm surgery. (2015)
  • Author(s): Hayashi K, Hirashiki A, Kodama A, Kobayashi K, Yasukawa Y, Shimizu M, Kondo T, Komori K, Murohara T.
  • Journal Title: Heart Vessels Volume: 1
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Prognostic impact of combined late gadolinium enhancement on cardiovascular magnetic resonance and peak oxygen consumption in ambulatory patients with nonischemic dilated cardiomyopathy. (2014)
  • Author(s): Yamada T, Hirashiki A, Okumura T, Adachi S, Shimazu S, Shimizu S, Morimoto R, Takeshita K, Naganawa S, Kondo T, Murohara T.
  • Journal Title: Journal of Card iac Failure Volume: 20 Pages: 825-32
  • DOI: 10.1016/j.cardfail.2014.08.005
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Combination therapy adding tadalafil to existing ambrisentan in patients with pulmonary arterial hypertension. (2014)
  • Author(s): Hirashiki A, Kondo T, Murohara T.
  • Journal Title: Hypertens Res. 2014 Volume: 37 Pages: 488-489
  • DOI: 10.1038/hr.2014.37
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Cardiopulmonary exercise testing to evaluate the exercise capacity of patients with inoperable chronic thromboembolic pulmonary hypertension: An endothelin receptor antagonist improves the peak PETCO2. (2014)
  • Author(s): Hirashiki A, Adachi S, Nakano Y, Kono Y, Shimazu S, Shimizu S, Morimoto R, Okumura T, Takeshita K, Yamada S, Murohara T, Kondo T
  • Journal Title: Life Sci. Volume: 118 Pages: 397-403
  • DOI: 10.1016/j.lfs.2014.03.009
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Imatinib is partially effective for the treatment of pulmonary capillary hemangiomatosis. (2014)
  • Author(s): Adachi S, Hirashiki A, Kondo T, Nakaguro M, Ogawa A, Miyaji K, Matsubara H, Yokoi T, Murohara T
  • Journal Title: Intern Med Volume: 53 Pages: 603-7
  • NAID: 130003392705
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Prognostic factors in pulmonary arterial hypertension with Dana Point group 1. (2014)
  • Author(s): Adachi S, Hirashiki A, Nakano Y, Shimazu S, Murohara T, Kondo T.
  • Journal Title: Life Sci. Volume: 118 Pages: 404-409
  • DOI: 10.1016/j.lfs.2014.03.002
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Prognostic value of pulmonary hypertension in ambulatory patients with non-ischemic dilated cardiomyopathy. (2014)
  • Author(s): Hirashiki A, Kondo T, Adachi S, Nakano Y, Shimazu S, Shimizu S, Morimoto R, Okumura T, Murohara T.
  • Journal Title: Circ J Volume: 78 Pages: 1245-53
  • NAID: 130003391072
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Prognostic Value of Pulmonary Hypertension in Ambulatory Patients With Non-Ischemic Dilated Cardiomyopathy (2014)
  • Author(s): Hirashiki A, Kondo T, Adachi S, Nakano Y, Shimazu S, Shimizu S, Morimoto R, Okumura T, Murohara T.
  • Journal Title: Circ J. Volume: -
  • NAID: 130003391072
  • Peer Reviewed
• [Journal Article] Relationship of myocardial fibrosis to left ventricular and mitochondrial function in nonischemic dilated cardiomyopathy-a comparison of focal and interstitial fibrosis. (2013)
  • Author(s): Yamada T, Hirashiki A, Cheng XW, Okumura T, Shimazu S, Okamoto R, Shinoda N, Isobe S, Takeshita K, Naganawa S, Kondo T, Murohara T
  • Journal Title: Journal of Cardiac Failure. Volume: 8 Pages: 557-564
  • DOI: 10.1016/j.cardfail.2013.05.018
  • Peer Reviewed
• [Journal Article] Usefulness of serum cardiac troponins T and I to predict cardiac molecular changes and cardiac damage in patients with hypertrophic cardiomyopathy (2013)
  • Author(s): Okamoto R, Hirashiki A, Cheng XW, Yamada T, Shimazu S, Shinoda N, Okumura T, Takeshita K, Bando Y, Kondo T, Murohara T.
  • Journal Title: Int Heart J Volume: 54 Pages: 202-6
  • NAID: 130003364470
  • Peer Reviewed
• [Journal Article] Androgen receptor promotes sex-independent angiogenesis in response to ischemia and is required for activation of vascular endothelial growth factor receptor signaling. (2013)
  • Author(s): Yoshida S, Aihara KI, Ikeda Y, Sumitomo-Ueda Y, Uemoto R, Ishikawa K, Ise T, Yagi S, Iwase T, Mouri Y, Sakari M, Matsumoto T, Takeyama KI, Akaike M, Matsumoto M, Sata M, Walsh K, Kato S, Matsumoto T
  • Journal Title: Circulation. Volume: 128 Pages: 1728-1738
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Association Between Indoxyl Sulfate and Cardiac Dysfunction and Prognosis in Patients With Dilated Cardiomyopathy (2013)
  • Author(s): Shimazu S, Hirashiki A, Okumura T, Yamada T, Okamoto R, Shinoda N, Takeshita K, Kondo T, Niwa T, Murohara T
  • Journal Title: Circ J Volume: 77(2) Pages: 390-6
  • NAID: 10031138916
  • Peer Reviewed
• [Journal Article] Increased (99m)Tc-sestamibi washout reflects impaired myocardial contractile and relaxation reserve during dobutamine stress due to mitochondrial dysfunction in dilated cardiomyopathy patients. (2013)
  • Author(s): Hayashi D, Ohshima S, Isobe S, Cheng XW, Unno K, Funahashi H, Shinoda N, Okumura T, Hirashiki A, Kato K, Murohara T.
  • Journal Title: Journal of the American College of Cardiology. Volume: 1 Pages: 1-2
  • DOI: 10.1016/j.jacc.2013.01.074
  • Peer Reviewed
• [Journal Article] Epicardial fat volume correlates with severity of coronary artery disease in nonobese patients. (2013)
  • Author(s): Okada K, Ohshima S, Isobe S, Harada K, Hirashiki A, Funahashi H, Arai K, Hayashi D, Hayashi M, Ishii H, Murohara T.
  • Journal Title: J Cardiovasc Med Volume: 1 Pages: 1-2
  • Peer Reviewed
• [Journal Article] Usefulness of serum cardiac troponins T and I to predict cardiac molecular changes and cardiac damage. (2013)
  • Author(s): Okamoto R, Hirashiki A, Cheng XW, Yamada T, MD,1 Shuzo Shimazu ,Shinoda N, Okumura T, Takeshita K, Bando Y,Kondo T, Murohara T
  • Journal Title: Int Heart J Volume: 1 Pages: 1-2
  • Peer Reviewed
• [Journal Article] Normal values of real-time 3-dimensional echocardiographic parameters in a healthy Japanese population: the JAMP-3D Study. (2012)
  • Author(s): Fukuda S, Watanabe H, Daimon M, Abe Y, Hirashiki A, Hirata K, Ito H, Iwai-Takano M, Yoshikawa J.
  • Journal Title: Circ J Volume: 76(5) Pages: 1177-81
  • NAID: 10030132612
  • Peer Reviewed
• [Journal Article] Development of the participation scale for patients with congestive heart failure. (2012)
  • Author(s): Makoto Suzuki, Sumio Yamada, Yuko Shimizu, Yuji Kono, Akihiro Hirashiki, Hideo Izawa, Toyoaki Murohara.
  • Journal Title: Am J Phys Med Rehabil Volume: 91 Pages: 1-10
  • DOI: 10.1097/phm.0b013e31824ad653
  • Peer Reviewed
• [Journal Article] Is magnetic resonance imaging of right ventricular volume useful clinically for evaluation of pulmonary arterial hypertension? (2012)
  • Author(s): Hirashiki A, Kondo T, Murohara T.
  • Journal Title: Circ J Volume: 76(7) Pages: 1595-6
  • NAID: 10030503105
• [Journal Article] Predictive value of functional limitation for disease severity in patients with mild chronic heart failure. (2012)
  • Author(s): Kono Y, Yamada S, Iwatsu K, Nitobe S, Tanaka Y, Shimizu Y, Shinoda N, Okumura T, Hirashiki A, Murohara T
  • Journal Title: J Cardiol Volume: 60(5) Pages: 411-5
  • DOI: 10.1016/j.jjcc.2012.07.009
  • Peer Reviewed
• [Journal Article] Prognostic Value of Heart Rate Recovery added to Brain Natriuretic Peptide in Ambulatory Patients with Nonischemic Dilated Cardiomyopathy. (2012)
  • Author(s): Shinoda N, Hirashiki A, Okumura T, Okamoto R, Wu Cheng X, Kono Y, Takeshita K, Yamada S, Murohara T
  • Journal Title: Annals of Noninvasive Electrocardiology Volume: 17(4) Pages: 378-386
  • DOI: 10.1111/j.1542-474x.2012.00542.x
  • Peer Reviewed
• [Presentation] Health-care quality of life over time during sequential combination therapy in pulmonary arterial hypertension. (2016)
  • Author(s): Hirashiki A, Shimokata S, Kamimura Y, Nakano Y, Adachi S, Okumura T, Takeshita K, Murohara T, Kondo T.
  • Organizer: 第80 回日本循環器学会学術集会
  • Place of Presentation: 宮城県仙台市 仙台国際センター
  • Year and Date: 2016-03-20
• [Presentation] Circulatory power and exercise ventilatory power during exercise over time during sequential combination therapy in pulmonary arterial hypertension (2016)
  • Author(s): Hirashiki A, Shimokata S, Kamimura Y, Nakano Y, Adachi S, Okumura T, Takeshita K, Murohara T, Kondo T. .
  • Organizer: 第80 回日本循環器学会学術集会
  • Place of Presentation: 宮城県仙台市 仙台国際センター
  • Year and Date: 2016-03-20
• [Presentation] ボセンタンによる末梢血管内皮機能の効果 -肺動脈性肺高血圧症と慢性血栓塞栓性肺高血圧症での比較-. (2015)
  • Author(s): 平敷安希博, 近藤隆久, 下方茂毅, 上村佳大, 中野嘉久, 足立史郎, 室原豊明
  • Organizer: 第23回日本血管生物医学会学術集会
  • Place of Presentation: 兵庫県神戸市 神戸国際会議場
  • Year and Date: 2015-12-10
• [Presentation] 肺高血圧領域における近年の治療の進歩と今後の展望」 肺高血圧症における非侵襲的検査の有用性 ーCPXを中心にー (2015)
  • Author(s): 平敷安希博，近藤隆久，室原豊明.
  • Organizer: 第52回日本臨床生理学会総会
  • Place of Presentation: 埼玉県大宮市 大宮ソニックシティ
  • Year and Date: 2015-10-31
  • Invited
• [Presentation] 門脈圧亢進症性肺高血圧症におけるボセンタンの安全性と効果 (2015)
  • Author(s): 平敷安希博，近藤隆久，下方茂毅， 上村佳大， 中野嘉久， 足立史郎， 室原豊明.
  • Organizer: 第3回日本肺高血圧学会（JPHS）第4回日本肺循環学会（JPCS）合同学術集会
  • Place of Presentation: 東京都千代田区 ステーションコンファレンス東京
  • Year and Date: 2015-10-03
• [Presentation] Circulatory power and exercise ventilatory power during exercise over time during sequential combination therapy in pulmonary arterial hypertension. (2015)
  • Author(s): Hirashiki A, Shimokata S., Kamimura Y, Nakano Y, Adachi S, Okumura T, Takeshita K, T Murohara, Kondo T.
  • Organizer: ESC congress 2015
  • Place of Presentation: ロンドン イギリス ExCeL London
  • Year and Date: 2015-08-31
  • Int'l Joint Research
• [Presentation] Effects of bosentan on endothelial function by flow-mediated vasodilation in patients with pulmonary arterial hypertension compared to chronic thromboembolic pulmonary hypertension (2015)
  • Author(s): Kamimura Y, Hirashiki A, Shimokata S, Nakano Y, Adachi S, Takeshita K, Murohara T, Kondo T.
  • Organizer: ESC congress 2015
  • Place of Presentation: ロンドン イギリス ExCeL London
  • Year and Date: 2015-08-31
  • Int'l Joint Research
• [Presentation] 肺動脈性肺高血圧症における運動耐容能に基づく積極的併用療法の検討. (2015)
  • Author(s): 平敷安希博 近藤隆久 奥村貴裕 清水美帆 小林聖典 室原豊明.
  • Organizer: 第21回心臓リハビリテーション学会学術集会
  • Place of Presentation: 福岡県福岡市 福岡国際会議場
  • Year and Date: 2015-07-19
  • Invited
• [Presentation] 27. Hirashiki A, Kondo T, Adachi S, Nakano Y, Takeshita K, Murohara T. Effects of bosentan on exercise capacity in patients with pulmonary arterial hypertension versus chronic thromboembolic pulmonary hypertension. (2014)
  • Author(s): . Hirashiki A, Kondo T, Adachi S, Nakano Y, Takeshita K, Murohara T.
  • Organizer: The Thirteen International Conference on Endothelin
  • Place of Presentation: 東京都文京区 筑波大学東京キャンバス
  • Year and Date: 2014-09-12 – 2014-09-13
• [Presentation] Cardiopulmonary exercise testing as a diagnostic tool for the detection of pulmonary hypertension and prognostic value in patients with dilated cardiomyopathy (2014)
  • Author(s): Hirashiki A, Kondo T, Okumura T, Morimoto R, Adachi S, Shimazu S, Fukaya K, Sawamura A, Takeshita K, Murohara T. ,
  • Organizer: ESC congress 2014
  • Place of Presentation: Barcelona - Spain)
  • Year and Date: 2014-08-31 – 2014-09-03
• [Presentation] Prognostic value of pulmonary hypertension in ambulatory patients with non-ischemic left ventricular systolic dysfunction. (2013)
  • Author(s): Hirashiki A, Kondo T, Okumura T, Murohara T.
  • Organizer: 第61回日本心臓病学会学術集会
  • Place of Presentation: ホテル日航熊本（熊本市）
• [Presentation] 肺高血圧を合併した拡張型心筋症の頻度と予後 (2013)
  • Author(s): 平敷安希博, 近藤隆久, 奥村貴裕, 室原豊明.
  • Organizer: 第１回日本肺高血圧学会
  • Place of Presentation: 慶應義塾大学 日吉キャンパス 協生館（横浜市）
• [Presentation] Clinical safety and usefulness of cardiopulmonary exercise testing for pulmonary hypertension. (2013)
  • Author(s): Hirashiki A, Kondo T, Adachi S, Shimizu S, Shimazu S, Kono Y, Yamada S, Okumura T, Takeshita K, Murohara T.
  • Organizer: ESC congress 2013
  • Place of Presentation: Amsterdam-Netherland
• [Presentation] Prognostic value of pulmonary hypertension in ambulatory patients with non-ischemic left ventricular systolic dysfunction. (2013)
  • Author(s): Hirashiki A, Kondo T, Okumura T, Adachi S, Morimoto R, Shimazu S, Shimizu S, Murohara T.
  • Organizer: ESC congress 2013
  • Place of Presentation: Amsterdam-Netherland
• [Presentation] Relation of myocardial fibrosis to left ventricular and mitochondrial function in nonischemic dilated cardiomyopathy. -a comparison focal and interstitial fibrosis- (2012)
  • Author(s): Yamada T, Hirashiki A, Cheng XW, Okumura T, Shimazu S, Okamoto R, Shinoda N, Takeshita K, Murohara T.
  • Organizer: ESC congress 2012
  • Place of Presentation: Munich(ドイツ)
• [Presentation] Prognostic value of serum indoxyl sulfate in patients with nonischemic dilated cardiomyopathy (2012)
  • Author(s): Shimazu S, Hirashiki A, Okumura T, Okamoto R, Yamada T, Takeshita K, XW. Cheng, Kondo T, Niwa T, Murohara T
  • Organizer: ESC congress 2012
  • Place of Presentation: Munich（ドイツ）
• [Presentation] Impact of serum cardiac troponin T and I on cardiac molecular changes (2012)
  • Author(s): Hirashiki A, Okamoto R, Yamada T, Shimazu S, Shinoda N, Cheng XW, Bando Y, Kondo T, Murohara T.
  • Organizer: ESC congress 2012
  • Place of Presentation: Munich（ドイツ）
• [Presentation] Prognostic role of the complication of both sleep-disordered breathing and chronic kidney disease in patients with idiopathic dilated cardiomyopathy. (2012)
  • Author(s): Hirashiki A, Kondo T, Okumura T, Shimazu S, Yamada T, Takeshita K, Murohara T.
  • Organizer: ESC congress 2012
  • Place of Presentation: Munich（ドイツ）
• [Presentation] CPXを用いて治療方針を決定したMCTD合併肺高血圧症の1例. (2012)
  • Author(s): 平敷 安希博、足立 史郎、松尾 大志、島津 修三、山田 崇史、近藤 隆久、室原 豊明.
  • Organizer: 第1回日本肺循環学会
  • Place of Presentation: 学術総合センター（東京）
• [Presentation] 剖検により診断し得たASD のEisenmenger 症候群に心筋梗塞を合併した1 例. (2012)
  • Author(s): 平敷 安希博、足立 史郎、島津 修三、近藤 隆久、室原豊明.
  • Organizer: 第1回日本肺循環学会
  • Place of Presentation: 学術総合センター（東京）
• [Presentation] 肺毛細血管腫症（PCH）にイマチニブを使用した一剖検例. (2012)
  • Author(s): 足立 史郎、平敷 安希博、松尾 大志、島津 修三、室原 豊明、近藤 隆久.
  • Organizer: 第1回日本肺循環学会
  • Place of Presentation: 学術総合センター（東京）
• [Presentation] 左室収縮機能不全における心肺運動負荷試験と副交感神経活性評価の意義. シンポジウム 循環器疾患と交感神経系 (2012)
  • Author(s): 平敷安希博、近藤隆久、奥村貴裕、坂東泰子、室原豊明.
  • Organizer: 第60回日本心臓病学会学術集会
  • Place of Presentation: ANAクラウンプラザホテル金沢(石川県)
• [Presentation] 拡張型心筋症における線維化と左心機能との関連 －心臓MRIと心筋生検での評価の比較－ (2012)
  • Author(s): 山田崇史、平敷安希博、島津修三、岡本理絵、篠田典宏、奥村貴裕、坂東泰子、成憲武、室原豊明.
  • Organizer: 第60回日本心臓病学会学術集会
  • Place of Presentation: ANAクラウンプラザホテル金沢(石川県)
• [Book] 心不全患者に寄り添う 包括的心臓リハビリテーションを極める (2016)
  • Author(s): 平敷安希博，室原豊明
  • Total Pages: 160
  • Publisher: 文行堂