| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Outline of Final Research Achievements |
The expression of organic cation/carnitine transporter 2 (OCTN2) which uptakes carnitine with sodium in kidney was decreased at early hypertrophic stage in Dahl salt-sensitive rats that present hypertension and heart failure with preserved ejection fraction (HFpEF) with high salt diet. Urinary free-carnitine excretion also increased, and serum and cardiac level of carnitine decreased. Administration of L-carnitine with high salt diet from age 6 weeks attenuated the elevation of blood pressure and restored the expression of OCTN2 in kidney. Serum creatinine level was also attenuated with L-carnitine administration independently with systolic blood pressure. These data suggest that administration of carnitine may be effective to prevent the development of salt-sensitive hypertension, the worsening renal dysfunction and the transition to decompensated HFpEF.
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