Impact of Carnitine on Heart Failure with Preserved Ejection Fraction

• Project/Area Number: 24591049
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Osaka University
• Principal Investigator: SAKATA Yasushi 大阪大学, 医学(系)研究科(研究院), 教授 (00397671)
• Co-Investigator(Kenkyū-buntansha): OHTANI Tomohito 大阪大学, 大学院医学系研究科, 助教 (30623897) ; MANO Toshiaki 兵庫医科大学, 医学部, 准教授 (90379165)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: カルニチン / 心不全 / 食塩感受性 / 拡張不全

Outline of Final Research Achievements

The expression of organic cation/carnitine transporter 2 (OCTN2) which uptakes carnitine with sodium in kidney was decreased at early hypertrophic stage in Dahl salt-sensitive rats that present hypertension and heart failure with preserved ejection fraction (HFpEF) with high salt diet. Urinary free-carnitine excretion also increased, and serum and cardiac level of carnitine decreased. Administration of L-carnitine with high salt diet from age 6 weeks attenuated the elevation of blood pressure and restored the expression of OCTN2 in kidney. Serum creatinine level was also attenuated with L-carnitine administration independently with systolic blood pressure. These data suggest that administration of carnitine may be effective to prevent the development of salt-sensitive hypertension, the worsening renal dysfunction and the transition to decompensated HFpEF.

Research Products

• [Journal Article] Usefulness of Transient Elastography for Non-invasive and Reliable Estimation of Right-sided Filling Pressure in Heart Failure (2014)
  • Author(s): Taniguchi T, Sakata Y, Ohtani T, Mizote I, Takeda Y, Asano Y, MasudaM, Minamiguchi H, Kanzaki M,Ichibori Y, Nishi H, Toda K, Sawa Y, Komuro I
  • Journal Title: Am J Cardiol Volume: 113 Pages: 552-558
  • Peer Reviewed
• [Journal Article] Endovascular Aortic Repair Increases Vascular Stiffness and Alters Cardiac Structure and Function. (2014)
  • Author(s): 93. Takeda Y, Sakata Y*, Ohtani T, Tamaki S, Omori Y, Tsukamoto Y, Aizawa Y, Shimamura K, Shirakawa Y, Kuratani T, Sawa Y, Yamamoto K, Mano T, Komuro I
  • Journal Title: Circ J Volume: 78 Pages: 322-328
  • NAID: 130003382224
• [Presentation] HFpEFはどのように考えて治療すれば良いのか (2014)
  • Author(s): 坂田泰史
  • Organizer: 日本高血圧学会
  • Place of Presentation: 横浜
  • Year and Date: 2014-10-17
  • Invited