Impact of endothelial lipase on dysfunctional HDL and atherosclerosis
Project/Area Number |
24591050
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Circulatory organs internal medicine
|
Research Institution | Kobe University |
Principal Investigator |
ISHIDA Tatsuro 神戸大学, 医学研究科, 特命教授 (00379413)
|
Co-Investigator(Kenkyū-buntansha) |
HIRATA Ken-ichi 神戸大学, 大学院医学研究科, 教授 (20283880)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | HDL / コレステロール / 血管内皮 / リパーゼ / 循環器 / 動脈硬化 / 炎症 / 脂質異常症 / 高比重リポ蛋白 / 血管内皮リパーゼ / dysfunctional HDL / ミエロペルオキシダーゼ / パラオキソナーゼ / 冠動脈疾患 / オメガ3系脂肪酸 / スタチン |
Outline of Final Research Achievements |
This study investigated the role of endothelial lipase (EL) on dysfunctional high-density lipoprotein (HDL) and coronary artery disease. We found that EL has a modest impact on baseline HDL-C levels. EL expression is elevated in inflammation, acute myocardial infarction, or postprandial states, which was associated with the reduction of serum HDL-C levels. The inflammation-activated EL may contribute to the low HDL-C levels in these pathological states. Next, we established clinical and in vitro cell-based assays for HDL quality. The presence of dysfunctional HDL modulated the progression of coronary artery lesions through regulating functional quality of HDL. Administration of pitavastatin or eicosapentaenoic acid improved anti-inflammatory, anti-oxidative, and cholesterol efflux capacity of HDL in dyslipidemic patients, and these drugs may be useful for treatment of dysfunctional HDL. Taken together, EL and dysfunctional HDL may exert a marker and modulator of atherosclerosis.
|
Report
(4 results)
Research Products
(35 results)
-
-
[Journal Article] Administration of high dose eicosapentaenoic acid enhances anti-inflammatory properties of high-density lipoprotein in Japanese patients with dyslipidemia2014
Author(s)
Tanaka N, Ishida T, Nagao M, Mori T, Monguchi T, Sasaki M, Mori K, Kondo K, Nakajima H, Honjo T, Irino Y, Toh R, Shinohara M, Hirata K
-
Journal Title
Atherosclerosis
Volume: 237
Issue: 2
Pages: 577-583
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
[Journal Article] Serum myeloperoxidase/paraoxonase 1 ratio as potential indicator of dysfunctional high-density lipoprotein and risk stratification in coronary artery disease.2014
Author(s)
Haraguchi Y1, Toh R2, Hasokawa M1, Nakajima H1, Honjo T1, Otsui K1, Mori K1, Miyamoto-Sasaki M1, Shinohara M1, Nishimura K3, Ishida T1, Hirata KI1
-
Journal Title
Atherosclerosis
Volume: 234
Issue: 2
Pages: 288-294
DOI
Related Report
Peer Reviewed / Open Access
-
-
[Journal Article] Serum myeloperoxidase/paraoxonase 1 ratio as potential indicator of dysfunctional high-density lipoprotein and risk stratification in coronary artery disease.2014
Author(s)
Haraguchi Y, Toh R, Hasokawa M, Nakajima H, Honjo T, Otsui K, Mori K, Miyamoto-Sasaki M, Shinohara M, Nishimura K, Ishida T, Hirata K.
-
Journal Title
Atherosclerosis
Volume: 234
Pages: 288-294
Related Report
Peer Reviewed
-
-
-
[Journal Article] Vasospasm of Atherosclerotic Coronary Arteries Precipitates Acute Ischemic Myocardial Damage in Myocardial Infarction-Prone Strain of the Watanabe Heritable Hyperlipidemic Rabbits.2013
Author(s)
Shiomi M, Ishida T, Kobayashi T, Nitta N, Sonoda A, Yamada S, Koike T, Kuniyoshi N, Murata K, Hirata KI, Ito T, Libby P.
-
Journal Title
Arteriosclerosis, Thrombosis, and Vascular Biology
Volume: 33
Issue: 11
Pages: 2518-2523
DOI
Related Report
Peer Reviewed
-
[Journal Article] Endothelial Lipase Modulates Pressure Overload- Induced Heart Failure Through Alternative Pathway for Fatty Acid Uptake.2013
Author(s)
Nakajima H, Ishida T, Satomi-Kobayashi S, Mori K, Hara T, Sasaki N, Yasuda T, Toh R, Tanaka H, Kawai H, Hirata K
-
Journal Title
Hypertension
Volume: 61(5)
Issue: 5
Pages: 1002-7
DOI
Related Report
Peer Reviewed
-
[Journal Article] Fasting serum concentration of apolipoprotein B48 represents residual risks in patients with new-onset and chronic coronary artery disease.2013
Author(s)
Mori K, Ishida T, Yasuda T, Monguchi T, Sasaki M, Kondo K, Hasokawa M, Nakajima H, Haraguchi Y, Sun L, Shinohara M, Toh R, Nishimura K, Hirata K.
-
Journal Title
Clin Chim Acta.
Volume: 421
Pages: 51-56
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
[Presentation] Eicosapentaenoic acid improves anti-inflammatory functions of high-density lipoprotein in dyslipidemic patients.2014
Author(s)
Nobuaki Tanaka, Tatsuro Ishida, Manabu Nagao, Takeshige Mori, Tomoko Monguchi, Maki Sasaki, Kenta Mori, Kensuke Kondo, Hideto Nakajima, Tomoyuki Honjo, Ryuji Toh, Ken-ichi Hirata.
Organizer
第46回日本動脈硬化学会総会
Place of Presentation
東京
Year and Date
2014-07-10 – 2014-07-11
Related Report
-
[Presentation] Inflammation-Activated Angptl3-Endothelial Lipase System Regulates Serum HDL-C Levels in Acute Coronary Syndrome.2014
Author(s)
Kenta Mori, Tatsuro Ishida, Kazuya miyashita, Noriaki Kinoshita, Hideto Nakajima, Tomoyuki Yasuda, Ryuji Toh, Masahito Kawata, Susumu Sakamoto, Katsuyuki Nakajima, Ken-ichi Hirata.
Organizer
第46回日本動脈硬化学会総会
Place of Presentation
東京
Year and Date
2014-07-10 – 2014-07-11
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] Impact of Serum Mass of Endothelial Lipase on Serum High-Density Lipoprotein-Cholesterol Concentrations in Acute Myocardial Infarction
Author(s)
Kenta Mori, Tatsuro Ishida, Manabu Nagao, Nobuaki Tanaka, Takeshige Mori, Tomoko Monguchi, Maki Sasaki, Kensuke Kondo, Hideto Nakajima, Tomoyuki Honjo, Ryuji Toh, Masahito Kawata, Susumu Sakamoto, Ken-ichi Hirata.
Organizer
The 78th Annual Scientific Meeting of the Japanese Circulation Society
Place of Presentation
東京
Related Report
-
[Presentation] Effect of cholesteryl ester transfer protein inhibitor on anti-inflammatory properties of high-density lipoproteins
Author(s)
Kenta Mori, Tatsuro Ishida, Tomoyuki Yasuda,Manabu Nagao, Nobuaki Tanaka, Takeshige Mori, Tomoko Monguchi, Maki Sasaki, Kensuke Kondo, Hideto Nakajima, Tomoyuki Honjo, Masashi Shiomi, Ken-ichi Hirata
Organizer
The 78th Annual Scientific Meeting of the Japanese Circulation Society
Place of Presentation
東京
Related Report
-
[Presentation] Impact of oral eicosapentaenoic acid therapy on High-Density Lipoprotein function in patients with high risk of atherosclerosis
Author(s)
Nobuaki Tanaka, Tatsuro Ishida, Manabu Nagao, Takeshige Mori, Tomoko Monguchi, Maki Sasaki, Kenta Mori, Kensuke Kondo, Hideto Nakajima, Tomoyuki Honjo, Ryuji Toh, Ken-ichi Hirata
Organizer
The 78th Annual Scientific Meeting of the Japanese Circulation Society
Place of Presentation
東京
Related Report
-
-