New risk stratification for cardiac sudden death by using signal averaged fragmented QRS complex
Project/Area Number |
24591051
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Circulatory organs internal medicine
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Research Institution | Okayama University |
Principal Investigator |
MORITA Hiroshi 岡山大学, 医歯(薬)学総合研究科, 教授 (50322227)
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Co-Investigator(Kenkyū-buntansha) |
TOH Norihisa 岡山大学, 大学病院, 助教 (70600641)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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Keywords | 心臓突然死 / fragmented QRS / 伝導障害 / 不整脈基質 / 12誘導心電図 / 分裂性QRS電位 / 心室頻拍 / 心室細動 / 心臓性突然死 |
Outline of Final Research Achievements |
We created a software to analyze signal averaged fragmented QRS (fQRS) and evaluated its significances on various heart diseases. In 321 patients with Brugada syndrome, existence of fQRS, early repolarization and spontaneous fluctuation of the ST level were predictors of the ventricular fibrillation (VF) occurrence. In patients with new onset VF, aggravation of the fQRS occurred and progression of the myocardial injury should be required for occurrence of VF. In 78 patients with non-ischemic dilated cardiomyopathy, existence of fQRS predicted occurrence of heart failure. In p127 patients with sarcoidosis, fQRS predicted occurrence of ventricular tachycardaia.
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Report
(4 results)
Research Products
(43 results)
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[Journal Article] Risk Stratification in Patients With Brugada Syndrome Without Previous Cardiac Arrest2015
Author(s)
Okamura H, Kamakura T, Morita H, Tokioka K, Nakajima I, Wada M, Ishibashi K, Miyamoto K, Noda T, Aiba T, Nishii N, Nagase S, Shimizu W, Yasuda S, Ogawa H, Kamakura S, Ito H, Ohe T, Kusano KF
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Journal Title
Circulation Journal
Volume: 79
Issue: 2
Pages: 310-317
DOI
NAID
ISSN
1346-9843, 1347-4820
Related Report
Peer Reviewed / Open Access
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[Journal Article] Pioglitazone prevents the endothelial dysfunction induced by ischemia and reperfusion in healthy subjects2014
Author(s)
Sakatani Y, Miyoshi T, Oe H, Noda Y, Ohno Y, Nakamura K, Saito Y, Osawa K, Morita H, Kohno K, Ito H
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Journal Title
Journal of cardiovascular pharmacology
Volume: 64
Issue: 4
Pages: 326-331
DOI
Related Report
Peer Reviewed
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[Journal Article] Additional diagnostic value of first-pass myocardial perfusion imaging without stress when combined with 64-row detector coronary ct angiography in patients with coronary artery disease2014
Author(s)
Osawa K, Miyoshi T, Koyama Y, Hashimoto K, Sato S, Nakamura K, Nishii N, Kohno K, Morita H, Kanazawa S, Ito H
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Journal Title
Heart
Volume: 100
Issue: 13
Pages: 1008-1915
DOI
Related Report
Peer Reviewed
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[Journal Article] Prognostic significance of early repolarization in inferolateral leads in Brugada patients with documented ventricular fibrillation: a novel risk factor for Brugada syndrome with ventricular fibrillation.2013
Author(s)
Kawata H, Morita H, Yamada Y, Noda T, Satomi K, Aiba T, Isobe M, Nagase S, Nakamura K, Fukushima Kusano K, Ito H, Kamakura S, Shimizu W.
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Journal Title
Heart Rhythm.
Volume: 10
Issue: 8
Pages: 1161-1168
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Fragmented QRS complex on 12-lead ECG is a predictor of ventricular tachyarrhythmia in patients with systemic sarcoidosis
Author(s)
Yutaka Take, Hiroshi Morita, Kimikazu Banba, Norihisa Toh, Eiki Hirose, Atsushi Hirohata, Kazufumi Nakamura, Kunihisa Kohno, Kengo Kusano, Keizo Yamamoto, Tohru Ohe, Hiroshi Ito
Organizer
第77回日本循環器学会学術集会
Place of Presentation
横浜
Related Report
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