Identification and Effects of KCNH2 (HERG) current-activating factor

• Project/Area Number: 24591054
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Okayama University
• Principal Investigator: NAKAMURA Kazufumi 岡山大学, 医歯(薬)学総合研究科, 准教授 (10335630)
• Co-Investigator(Kenkyū-buntansha): MORITA Hiroshi 岡山大学, 医歯薬学総合研究科, 教授 (50322227) ; YOSHIDA Masashi 岡山大学, 医歯薬学総合研究科, 助教 (70532761) ; ITO Hiroshi 岡山大学, 医歯薬学総合研究科, 教授 (90446047)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 心室性不整脈 / HERG電流 / 心不全 / イオンチャネル / QT延長症候群 / HEK293細胞 / 自己免疫 / QT短縮症候群 / サブクローニング / 血液 / KCNH2 / 電流活性化因子 / 心臓突然死

Outline of Final Research Achievements

In order to improve the prognosis in patients with heart failure, to solve the mechanism of ventricular tachyarrhythmia and to find new target of treatment for ventricular tachyarrhythmia are needed. KCNH2 (HERG) channel is related to congenital long or short QT syndrome and is one of the most susceptible channel. We found ciruculating KCNH2(HERG) current-activating factor in patients with heart failure and ventricular tachyarrhythmia. We also found anti-KCNH2 antibody.

Research Products

• [Journal Article] 重症心不全に伴う不整脈の薬物治療 (2012)
  • Author(s): 中村一文、中川晃志、杉山洋樹、森田宏、草野研吾、伊藤浩
  • Journal Title: 呼吸と循環 Volume: 60(4)