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Identification and Effects of KCNH2 (HERG) current-activating factor

Research Project

Project/Area Number 24591054
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionOkayama University

Principal Investigator

NAKAMURA Kazufumi  岡山大学, 医歯(薬)学総合研究科, 准教授 (10335630)

Co-Investigator(Kenkyū-buntansha) MORITA Hiroshi  岡山大学, 医歯薬学総合研究科, 教授 (50322227)
YOSHIDA Masashi  岡山大学, 医歯薬学総合研究科, 助教 (70532761)
ITO Hiroshi  岡山大学, 医歯薬学総合研究科, 教授 (90446047)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords心室性不整脈 / HERG電流 / 心不全 / イオンチャネル / QT延長症候群 / HEK293細胞 / 自己免疫 / QT短縮症候群 / サブクローニング / 血液 / KCNH2 / 電流活性化因子 / 心臓突然死
Outline of Final Research Achievements

In order to improve the prognosis in patients with heart failure, to solve the mechanism of ventricular tachyarrhythmia and to find new target of treatment for ventricular tachyarrhythmia are needed. KCNH2 (HERG) channel is related to congenital long or short QT syndrome and is one of the most susceptible channel. We found ciruculating KCNH2(HERG) current-activating factor in patients with heart failure and ventricular tachyarrhythmia. We also found anti-KCNH2 antibody.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (1 results)

All 2012

All Journal Article (1 results)

  • [Journal Article] 重症心不全に伴う不整脈の薬物治療2012

    • Author(s)
      中村一文、中川晃志、杉山洋樹、森田宏、草野研吾、伊藤浩
    • Journal Title

      呼吸と循環

      Volume: 60(4)

    • Related Report
      2012 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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