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The role of clock gene in cardiovascular disease

Research Project

Project/Area Number 24591060
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionSaga University

Principal Investigator

NODE Koichi  佐賀大学, 医学部, 教授 (80359950)

Co-Investigator(Kenkyū-buntansha) KATSUYA Tomohiro  大阪大学, 医学系研究科, 准教授 (30311757)
SAKATA Yasuhiko  大阪大学, 医学系研究科, 准教授 (90379206)
IMAI Yutaka  東北大学, 薬学研究科, 教授 (40133946)
OYAMA Jun-ichi  佐賀大学, 医学部, 寄附講座教授 (30359939)
Co-Investigator(Renkei-kenkyūsha) AKASHI Makoto  山口大学, 時間学研究所, 教授 (30398119)
SATO Yasunori   (90536723)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords時計遺伝子 / 運動 / 体内リズム / 生活習慣 / 循環器病 / 急性冠症候群 / コホート研究 / バイオマーカー / 慢性心不全 / ゲノム多型
Outline of Final Research Achievements

In this research, we measured the clock gene expression in hair follicle cells for the purpose of assessing the effect of exercise on circadian rhythm. Intensive exercise before sleep significantly shifted the phase of PER3. On the other hand, there was no significant difference in the amplitude of the PER3 rhythm. Nighttime excessive exercise results the change of the phase of PER3, and eventually influence the quality of sleep. There is a possibility that exercise therapy could be the treatment for disorders caused by dysrhythmia, and in order to maintain normal circadian rhythm in the body, athletes need to manage the schedule for exercise hours to obtain efficient results from exercise.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (27 results)

All 2014 2013 2012

All Journal Article (9 results) (of which Peer Reviewed: 9 results,  Open Access: 2 results,  Acknowledgement Compliant: 2 results) Presentation (7 results) (of which Invited: 7 results) Book (11 results)

  • [Journal Article] The mammalian circadian clock protein period counteracts cryptochrome in phosphorylation dynamics of circadian locomotor output cycles kaput (CLOCK).2014

    • Author(s)
      Matsumura R, Tsuchiya Y, Tokuda I, Matsuo T, Sato M, Node K, Nishida E, Akashi M.
    • Journal Title

      J Biol Chem.

      Volume: 289(46) Issue: 46 Pages: 32064-72

    • DOI

      10.1074/jbc.m114.578278

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The role of the endocrine system in feeding-induced tissue-specific circadian entrainment.2014

    • Author(s)
      Sato M, Murakami M, Node K, Matsumura R, Akashi M.
    • Journal Title

      Cell Rep.

      Volume: 8(2) Issue: 2 Pages: 393-401

    • DOI

      10.1016/j.celrep.2014.06.015

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A Positive Role for PERIOD in Mammalian Circadian Gene Expression.2014

    • Author(s)
      Akashi M, Okamoto A, Tsuchiya Y, Todo T, Nishida E, Node K.
    • Journal Title

      Cell Rep.

      Volume: 7(4) Issue: 4 Pages: 1056-64

    • DOI

      10.1016/j.celrep.2014.03.072

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Compensation for intracellular environment in expression levels of mammalian circadian clock genes.2014

    • Author(s)
      Matsumura R, Okamoto A, Node K, Akashi M.
    • Journal Title

      Sci Rep.

      Volume: 4 Issue: 1 Pages: 4032-4032

    • DOI

      10.1038/srep04032

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Nuclear receptor-mediated cell-autonomous oscillatory expression of the circadian transcription factor, neuronal PAS domain protein 2.2013

    • Author(s)
      Matsumura R et al.
    • Journal Title

      J Biol Chem

      Volume: 288 Issue: 51 Pages: 36548-53

    • DOI

      10.1074/jbc.m113.517235

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] An out-of-lab trial: a case example for the effect of intensive exercise on rhythms of human clock gene expression.2013

    • Author(s)
      Okamoto A, Yamamoto T, Matsumura R, Node K, Akashi M.
    • Journal Title

      J Circadian Rhythms.

      Volume: 11(1) Issue: 0 Pages: 10-10

    • DOI

      10.1186/1740-3391-11-10

    • NAID

      120005367883

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] A molecular clock regulates angiopoietin-like protein 2 expression.2013

    • Author(s)
      Kadomatsu T et al
    • Journal Title

      PloS One

      Volume: 8 Issue: 2 Pages: e57921-e57921

    • DOI

      10.1371/journal.pone.0057921

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effects of sitagliptin beyond glycemic control: focus on quality of life.2013

    • Author(s)
      Sakamoto Y, Oyama J, Ikeda H, Kuroki S, Gondo S, Iwamoto T, Uchida Y, Kodama K, Hiwatashi A, Shimomura M, Taguchi I, Inoue T, Node K; S-DOG investigators.
    • Journal Title

      Cardiovasc Diabetol.

      Volume: 12 Issue: 1 Pages: 35-35

    • DOI

      10.1186/1475-2840-12-35

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Predictive value of high-molecular weight adiponectin in subjects with a higher risk of the development of metabolic syndrome: From a population based 5-year follow-up data.2013

    • Author(s)
      Kotooka N, Komatsu A, Takahashi H, Nonaka M, Kawaguchi C, Komoda H, Asaka M, Abe S, Taguchi I, Toyoda S, Nishiyama M, Inoue T, Node K.
    • Journal Title

      Int J Cardiol.

      Volume: 167(3) Issue: 3 Pages: 1068-70

    • DOI

      10.1016/j.ijcard.2012.10.066

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Time is Life-体内時計制御でアンチエイジング2014

    • Author(s)
      野出孝一
    • Organizer
      脳心血管抗加齢研究会
    • Place of Presentation
      梅田スカイビル(大阪府大阪市)
    • Year and Date
      2014-12-07
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 体内時計と生活習慣病治療2013

    • Author(s)
      野出孝一
    • Organizer
      第56回日本糖尿病学会年次学術集会
    • Place of Presentation
      熊本
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 体内時計と循環器疾患2013

    • Author(s)
      野出孝一、佐藤迪夫、長友大輔、錦戸利幸、尾山純一
    • Organizer
      日本心臓病学会誌
    • Place of Presentation
      熊本
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 高血圧と時計遺伝子2013

    • Author(s)
      野出孝一
    • Organizer
      第21回日本血管生物医学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 高血圧と時計遺伝子2012

    • Author(s)
      野出孝一
    • Organizer
      日本高血圧学会第1回臨床高血圧フォーラム
    • Place of Presentation
      大阪
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 心血管不全と体内時計2012

    • Author(s)
      野出孝一
    • Organizer
      第12回日本抗加齢医学会総会
    • Place of Presentation
      神奈川
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 体内時計と心血管疾患2012

    • Author(s)
      野出孝一
    • Organizer
      第24回日本糖尿病性腎症研究会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
    • Invited
  • [Book] 時計からみた高齢者循環器疾患2014

    • Author(s)
      加藤徹、野出孝一
    • Total Pages
      289
    • Publisher
      科学評論社
    • Related Report
      2014 Annual Research Report
  • [Book] 高血圧発症にかかわる時計遺伝子の役割2014

    • Author(s)
      錦戸利幸、野出孝一
    • Total Pages
      1503
    • Publisher
      日本臨床社
    • Related Report
      2014 Annual Research Report
  • [Book] 体内時計と血管疾患2014

    • Author(s)
      錦戸利幸、野出孝一
    • Total Pages
      96
    • Publisher
      医学書院
    • Related Report
      2014 Annual Research Report
  • [Book] 呼吸と循環 体内時計と心血管疾患2014

    • Author(s)
      錦戸利幸、野出孝一
    • Publisher
      医学書院
    • Related Report
      2013 Research-status Report
  • [Book] 日本心臓病学会誌 体内時計と循環器疾患2013

    • Author(s)
      野出孝一、佐藤迪夫、長友大輔、錦戸利幸、尾山純一
    • Total Pages
      175
    • Publisher
      日本心臓病学会
    • Related Report
      2013 Research-status Report
  • [Book] 成人病と生活習慣病 バイオリズムと生活習慣病2013

    • Author(s)
      野出孝一
    • Publisher
      東京医学社
    • Related Report
      2013 Research-status Report
  • [Book] 動脈硬化症の新しい診断・治療標的 時計遺伝子2012

    • Author(s)
      江本憲昭、野出孝一
    • Total Pages
      8
    • Publisher
      メディカルレビュー社
    • Related Report
      2012 Research-status Report
  • [Book] Heart View 体内リズムと循環器病2012

    • Author(s)
      野出孝一
    • Total Pages
      2
    • Publisher
      メジカルビュー社
    • Related Report
      2012 Research-status Report
  • [Book] Heart View 概日時計の振動原理2012

    • Author(s)
      明石真、野出孝一
    • Total Pages
      8
    • Publisher
      メジカルビュー社
    • Related Report
      2012 Research-status Report
  • [Book] Heart View 循環器病のバイオマーカー2012

    • Author(s)
      尾山純一、野出孝一
    • Total Pages
      5
    • Publisher
      メジカルビュー社
    • Related Report
      2012 Research-status Report
  • [Book] 実験治療 現代型不眠と生活習慣病2012

    • Author(s)
      兒玉和久、野出孝一
    • Total Pages
      4
    • Publisher
      武田薬品工業
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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